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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Macrophage-stimulating protein receptor''' is a [[protein]] that in humans is encoded by the ''MST1R'' [[gene]].<ref name="pmid8386824">{{cite journal |vauthors=Ronsin C, Muscatelli F, Mattei MG, Breathnach R | title = A novel putative receptor protein tyrosine kinase of the met family | journal = Oncogene | volume = 8 | issue = 5 | pages = 1195–202 |date=May 1993 | pmid = 8386824 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4486| accessdate = }}</ref> MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the [[c-MET]] receptor tyrosine kinase.<ref name="pmid8386824" /><ref name="pmid8062829">{{cite journal |vauthors=Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM | title = RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP | journal = EMBO J. | volume = 13 | issue = 15 | pages = 3524–32 |date=August 1994 | pmid = 8062829 | pmc = 395256 | doi = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
| HGNCid = 7381
| Symbol = MST1R
| AltSymbols =; CDw136; PTK8; RON
| OMIM = 600168
| ECnumber = 
| Homologene = 1835
| MGIid = 99614
| GeneAtlas_image1 = PBB_GE_MST1R_205455_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005011 |text = macrophage colony stimulating factor receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0001725 |text = stress fiber}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006952 |text = defense response}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007338 |text = single fertilization}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4486
    | Hs_Ensembl = ENSG00000164078
    | Hs_RefseqProtein = NP_002438
    | Hs_RefseqmRNA = NM_002447
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 49899444
    | Hs_GenLoc_end = 49916074
    | Hs_Uniprot = Q04912
    | Mm_EntrezGene = 19882
    | Mm_Ensembl = ENSMUSG00000032584
    | Mm_RefseqmRNA = NM_009074
    | Mm_RefseqProtein = NP_033100
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 9
    | Mm_GenLoc_start = 107764990
    | Mm_GenLoc_end = 107778488
    | Mm_Uniprot = Q62190
  }}
}}
'''Macrophage stimulating 1 receptor (c-met-related tyrosine kinase)''', also known as '''MST1R''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4486| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MST1R has been shown to [[Protein-protein interaction|interact]] with [[Grb2]].<ref name="pmid7488076">{{cite journal |vauthors=Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T | title = Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor | journal = Biochem. Biophys. Res. Commun. | volume = 216 | issue = 1 | pages = 110–8 |date=November 1995 | pmid = 7488076 | doi = 10.1006/bbrc.1995.2598 }}</ref><ref name="pmid8918464">{{cite journal |vauthors=Iwama A, Yamaguchi N, Suda T | title = STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family | journal = EMBO J. | volume = 15 | issue = 21 | pages = 5866–75 |date=November 1996 | pmid = 8918464 | pmc = 452340 | doi = }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Li BQ, Wang MH, Kung HF, etal |title=Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 1 |pages= 110–8 |year= 1995 |pmid= 7488076 |doi= 10.1006/bbrc.1995.2598 }}
| citations =
*{{cite journal   |vauthors=Wang MH, Ronsin C, Gesnel MC, etal |title=Identification of the ron gene product as the receptor for the human macrophage stimulating protein |journal=Science |volume=266 |issue= 5182 |pages= 117–9 |year= 1994 |pmid= 7939629 |doi=10.1126/science.7939629  }}
*{{cite journal | author=Li BQ, Wang MH, Kung HF, ''et al.'' |title=Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor. |journal=Biochem. Biophys. Res. Commun. |volume=216 |issue= 1 |pages= 110-8 |year= 1995 |pmid= 7488076 |doi= 10.1006/bbrc.1995.2598 }}
*{{cite journal   |vauthors=Gaudino G, Follenzi A, Naldini L, etal |title=RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP |journal=EMBO J. |volume=13 |issue= 15 |pages= 3524–32 |year= 1994 |pmid= 8062829 |doi= | pmc=395256 }}
*{{cite journal | author=Wang MH, Ronsin C, Gesnel MC, ''et al.'' |title=Identification of the ron gene product as the receptor for the human macrophage stimulating protein. |journal=Science |volume=266 |issue= 5182 |pages= 117-9 |year= 1994 |pmid= 7939629 |doi= }}
*{{cite journal  |vauthors=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal | author=Gaudino G, Follenzi A, Naldini L, ''et al.'' |title=RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP. |journal=EMBO J. |volume=13 |issue= 15 |pages= 3524-32 |year= 1994 |pmid= 8062829 |doi=  }}
*{{cite journal  |vauthors=Collesi C, Santoro MM, Gaudino G, Comoglio PM |title=A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5518–26 |year= 1996 |pmid= 8816464 |doi= | pmc=231551 }}
*{{cite journal  | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403-10 |year= 1993 |pmid= 8247543 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Ronsin C, Muscatelli F, Mattei MG, Breathnach R |title=A novel putative receptor protein tyrosine kinase of the met family. |journal=Oncogene |volume=8 |issue= 5 |pages= 1195-202 |year= 1993 |pmid= 8386824 |doi=  }}
*{{cite journal  |vauthors=Iwama A, Yamaguchi N, Suda T |title=STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family |journal=EMBO J. |volume=15 |issue= 21 |pages= 5866–75 |year= 1997 |pmid= 8918464 |doi= | pmc=452340 }}
*{{cite journal  | author=Collesi C, Santoro MM, Gaudino G, Comoglio PM |title=A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5518-26 |year= 1996 |pmid= 8816464 |doi=  }}
*{{cite journal   |vauthors=Sakamoto O, Iwama A, Amitani R, etal |title=Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility |journal=J. Clin. Invest. |volume=99 |issue= 4 |pages= 701–9 |year= 1997 |pmid= 9045873 |doi=10.1172/JCI119214  | pmc=507853 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal   |vauthors=Follenzi A, Bakovic S, Gual P, etal |title=Cross-talk between the proto-oncogenes Met and Ron |journal=Oncogene |volume=19 |issue= 27 |pages= 3041–9 |year= 2000 |pmid= 10871856 |doi= 10.1038/sj.onc.1203620 }}
*{{cite journal | author=Iwama A, Yamaguchi N, Suda T |title=STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family. |journal=EMBO J. |volume=15 |issue= 21 |pages= 5866-75 |year= 1997 |pmid= 8918464 |doi=  }}
*{{cite journal  |vauthors=Chen YQ, Zhou YQ, Fisher JH, Wang MH |title=Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo |journal=Oncogene |volume=21 |issue= 41 |pages= 6382–6 |year= 2002 |pmid= 12214279 |doi= 10.1038/sj.onc.1205783 }}
*{{cite journal | author=Sakamoto O, Iwama A, Amitani R, ''et al.'' |title=Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility. |journal=J. Clin. Invest. |volume=99 |issue= 4 |pages= 701-9 |year= 1997 |pmid= 9045873 |doi= }}
*{{cite journal   |vauthors=Chen YQ, Zhou YQ, Fu LH, etal |title=Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais |journal=Carcinogenesis |volume=23 |issue= 11 |pages= 1811–9 |year= 2002 |pmid= 12419829 |doi=10.1093/carcin/23.11.1811  }}
*{{cite journal  | author=Follenzi A, Bakovic S, Gual P, ''et al.'' |title=Cross-talk between the proto-oncogenes Met and Ron. |journal=Oncogene |volume=19 |issue= 27 |pages= 3041-9 |year= 2000 |pmid= 10871856 |doi= 10.1038/sj.onc.1203620 }}
*{{cite journal   |vauthors=Zhou YQ, He C, Chen YQ, etal |title=Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential |journal=Oncogene |volume=22 |issue= 2 |pages= 186–97 |year= 2003 |pmid= 12527888 |doi= 10.1038/sj.onc.1206075 }}
*{{cite journal | author=Chen YQ, Zhou YQ, Fisher JH, Wang MH |title=Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo. |journal=Oncogene |volume=21 |issue= 41 |pages= 6382-6 |year= 2002 |pmid= 12214279 |doi= 10.1038/sj.onc.1205783 }}
*{{cite journal   |vauthors=Danilkovitch-Miagkova A, Duh FM, Kuzmin I, etal |title=Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4580–5 |year= 2003 |pmid= 12676986 |doi= 10.1073/pnas.0837136100  | pmc=153598 }}
*{{cite journal | author=Chen YQ, Zhou YQ, Fu LH, ''et al.'' |title=Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d'origine nantais. |journal=Carcinogenesis |volume=23 |issue= 11 |pages= 1811-9 |year= 2002 |pmid= 12419829 |doi= }}
*{{cite journal   |vauthors=Rampino T, Gregorini M, Soccio G, etal |title=The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma |journal=Am. J. Surg. Pathol. |volume=27 |issue= 6 |pages= 779–85 |year= 2003 |pmid= 12766581 |doi=10.1097/00000478-200306000-00008  }}
*{{cite journal | author=Zhou YQ, He C, Chen YQ, ''et al.'' |title=Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. |journal=Oncogene |volume=22 |issue= 2 |pages= 186-97 |year= 2003 |pmid= 12527888 |doi= 10.1038/sj.onc.1206075 }}
*{{cite journal  |vauthors=Penengo L, Rubin C, Yarden Y, Gaudino G |title=c-Cbl is a critical modulator of the Ron tyrosine kinase receptor |journal=Oncogene |volume=22 |issue= 24 |pages= 3669–79 |year= 2003 |pmid= 12802274 |doi= 10.1038/sj.onc.1206585 }}
*{{cite journal | author=Danilkovitch-Miagkova A, Duh FM, Kuzmin I, ''et al.'' |title=Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 8 |pages= 4580-5 |year= 2003 |pmid= 12676986 |doi= 10.1073/pnas.0837136100 }}
*{{cite journal   |vauthors=Maggiora P, Lorenzato A, Fracchioli S, etal |title=The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness |journal=Exp. Cell Res. |volume=288 |issue= 2 |pages= 382–9 |year= 2003 |pmid= 12915129 |doi=10.1016/S0014-4827(03)00250-7  }}
*{{cite journal  | author=Rampino T, Gregorini M, Soccio G, ''et al.'' |title=The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma. |journal=Am. J. Surg. Pathol. |volume=27 |issue= 6 |pages= 779-85 |year= 2003 |pmid= 12766581 |doi= }}
*{{cite journal  |vauthors=Santoro MM, Gaudino G, Marchisio PC |title=The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration |journal=Dev. Cell |volume=5 |issue= 2 |pages= 257–71 |year= 2003 |pmid= 12919677 |doi=10.1016/S1534-5807(03)00201-6 }}
*{{cite journal | author=Penengo L, Rubin C, Yarden Y, Gaudino G |title=c-Cbl is a critical modulator of the Ron tyrosine kinase receptor. |journal=Oncogene |volume=22 |issue= 24 |pages= 3669-79 |year= 2003 |pmid= 12802274 |doi= 10.1038/sj.onc.1206585 }}
*{{cite journal   |vauthors=Angeloni D, Danilkovitch-Miagkova A, Miagkov A, etal |title=The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3726–32 |year= 2004 |pmid= 14597639 |doi= 10.1074/jbc.M309342200 }}
*{{cite journal  | author=Maggiora P, Lorenzato A, Fracchioli S, ''et al.'' |title=The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. |journal=Exp. Cell Res. |volume=288 |issue= 2 |pages= 382-9 |year= 2003 |pmid= 12915129 |doi=  }}
*{{cite journal   |vauthors=van den Akker E, van Dijk T, Parren-van Amelsvoort M, etal |title=Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors |journal=Blood |volume=103 |issue= 12 |pages= 4457–65 |year= 2004 |pmid= 14982882 |doi= 10.1182/blood-2003-08-2713 }}
*{{cite journal | author=Santoro MM, Gaudino G, Marchisio PC |title=The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration. |journal=Dev. Cell |volume=5 |issue= 2 |pages= 257-71 |year= 2003 |pmid= 12919677 |doi= }}
*{{cite journal   |vauthors=Raeppel S, Gaudette G, etal |title=Identification of a novel series of potent RON receptor tyrosine kinase inhibitors |journal=Bioorg. Med. Chem. Lett. |volume=20 |issue= 9 |pages= 2745–9 |year= 2010 |doi= 10.1016/j.bmcl.2010.03.073 }}
*{{cite journal | author=Angeloni D, Danilkovitch-Miagkova A, Miagkov A, ''et al.'' |title=The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation. |journal=J. Biol. Chem. |volume=279 |issue= 5 |pages= 3726-32 |year= 2004 |pmid= 14597639 |doi= 10.1074/jbc.M309342200 }}
*{{cite journal | author=van den Akker E, van Dijk T, Parren-van Amelsvoort M, ''et al.'' |title=Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors. |journal=Blood |volume=103 |issue= 12 |pages= 4457-65 |year= 2004 |pmid= 14982882 |doi= 10.1182/blood-2003-08-2713 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 01:50, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[1][2] MST1R is also known as RON (Recepteur d'Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[1][3]

Interactions

MST1R has been shown to interact with Grb2.[4][5]

References

  1. ↑ 1.0 1.1 Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195–202. PMID 8386824.
  2. ↑ "Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)".
  3. ↑ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). "RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP". EMBO J. 13 (15): 3524–32. PMC 395256. PMID 8062829.
  4. ↑ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). "Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor". Biochem. Biophys. Res. Commun. 216 (1): 110–8. doi:10.1006/bbrc.1995.2598. PMID 7488076.
  5. ↑ Iwama A, Yamaguchi N, Suda T (November 1996). "STK/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family". EMBO J. 15 (21): 5866–75. PMC 452340. PMID 8918464.

Further reading


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