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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(i), alpha-2 subunit''' is a [[protein]] that in humans is encoded by the ''GNAI2'' [[gene]].<ref name="pmid3100330">{{cite journal | vauthors = Didsbury JR, Ho YS, Snyderman R | title = Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA | journal = FEBS Letters | volume = 211 | issue = 2 | pages = 160–4 | date = Jan 1987 | pmid = 3100330 | pmc =  | doi = 10.1016/0014-5793(87)81428-X }}</ref><ref name="pmid1733849">{{cite journal | vauthors = Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC | title = Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13 | journal = Genomics | volume = 12 | issue = 1 | pages = 125–9 | date = Jan 1992 | pmid = 1733849 | pmc = | doi = 10.1016/0888-7543(92)90414-N }}</ref><ref>{{cite web | title = Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2771| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
| HGNCid = 4385
| Symbol = GNAI2
| AltSymbols =; GIP; GNAI2B; H_LUCA15.1; H_LUCA16.1
| OMIM = 139360
| ECnumber = 
| Homologene = 55539
| MGIid = 95772
| GeneAtlas_image1 = PBB_GE_GNAI2_201040_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0019001 |text = guanyl nucleotide binding}}
| Component =
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007193 |text = G-protein signaling, adenylate cyclase inhibiting pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}} {{GNF_GO|id=GO:0007213 |text = acetylcholine receptor signaling, muscarinic pathway}} {{GNF_GO|id=GO:0007584 |text = response to nutrient}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2771
    | Hs_Ensembl = ENSG00000114353
    | Hs_RefseqProtein = NP_002061
    | Hs_RefseqmRNA = NM_002070
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 3
    | Hs_GenLoc_start = 50239173
    | Hs_GenLoc_end = 50271775
    | Hs_Uniprot = P04899
    | Mm_EntrezGene = 14678
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_980919
    | Mm_RefseqProtein = XP_986013
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2''', also known as '''GNAI2''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2771| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
GNAI2 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[EYA2]],<ref name = pmid10906137>{{cite journal | vauthors = Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR | title = The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins | journal = The Journal of Biological Chemistry | volume = 275 | issue = 41 | pages = 32129–34 | date = Oct 2000 | pmid = 10906137 | doi = 10.1074/jbc.M004577200 }}</ref>
| summary_text =  
* [[GPSM2]],<ref name = pmid12748287>{{cite journal | vauthors = Marty C, Browning DD, Ye RD | title = Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras | journal = Molecular and Cellular Biology | volume = 23 | issue = 11 | pages = 3847–58 | date = Jun 2003 | pmid = 12748287 | pmc = 155206 | doi =  10.1128/mcb.23.11.3847-3858.2003}}</ref><ref name = pmid8973305>{{cite journal | vauthors = Mochizuki N, Cho G, Wen B, Insel PA | title = Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2 | journal = Gene | volume = 181 | issue = 1-2 | pages = 39–43 | date = Nov 1996 | pmid = 8973305 | doi = 10.1016/s0378-1119(96)00456-8}}</ref>
}}
* [[Interleukin 8 receptor, alpha]],<ref name = pmid8903513>{{cite journal | vauthors = Damaj BB, McColl SR, Neote K, Songqing N, Ogborn KT, Hébert CA, Naccache PH | title = Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops | journal = FASEB Journal | volume = 10 | issue = 12 | pages = 1426–34 | date = Oct 1996 | pmid = 8903513 | doi =  }}</ref><ref name = pmid8662698>{{cite journal | vauthors = Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH | title = Physical association of Gi2alpha with interleukin-8 receptors | journal = The Journal of Biological Chemistry | volume = 271 | issue = 22 | pages = 12783–9 | date = May 1996 | pmid = 8662698 | doi =  10.1074/jbc.271.22.12783}}</ref>  
* [[MDFI]],<ref name = pmid16189514>{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = Oct 2005 | pmid = 16189514 | doi = 10.1038/nature04209 }}</ref>
* [[RGS5]],<ref name = pmid9079700>{{cite journal | vauthors = Chen C, Zheng B, Han J, Lin SC | title = Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast | journal = The Journal of Biological Chemistry | volume = 272 | issue = 13 | pages = 8679–85 | date = Mar 1997 | pmid = 9079700 | doi =  10.1074/jbc.272.13.8679}}</ref><ref name = pmid11253162>{{cite journal | vauthors = Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S | title = Characterization of RGS5 in regulation of G protein-coupled receptor signaling | journal = Life Sciences | volume = 68 | issue = 13 | pages = 1457–69 | date = Feb 2001 | pmid = 11253162 | doi =  10.1016/s0024-3205(01)00939-0}}</ref>  and
* [[RIC8A]].<ref name = pmid12509430>{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8356–62 | date = Mar 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Sidhu A, Niznik HB | title = Coupling of dopamine receptor subtypes to multiple and diverse G proteins | journal = International Journal of Developmental Neuroscience | volume = 18 | issue = 7 | pages = 669–77  | date = Nov 2000 | pmid = 10978845 | doi = 10.1016/S0736-5748(00)00033-2 }}
| citations =
* {{cite journal | vauthors = Offermanns S, Schultz G, Rosenthal W | title = Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells | journal = The Journal of Biological Chemistry | volume = 266 | issue = 6 | pages = 3365–8  | date = Feb 1991 | pmid = 1671672 | doi =  }}
*{{cite journal | author=Sidhu A, Niznik HB |title=Coupling of dopamine receptor subtypes to multiple and diverse G proteins. |journal=Int. J. Dev. Neurosci. |volume=18 |issue= 7 |pages= 669-77 |year= 2000 |pmid= 10978845 |doi= }}
* {{cite journal | vauthors = Cormont M, Le Marchand-Brustel Y, Van Obberghen E, Spiegel AM, Sharp GW | title = Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor | journal = Diabetes | volume = 40 | issue = 9 | pages = 1170–6  | date = Sep 1991 | pmid = 1718802 | doi = 10.2337/diabetes.40.9.1170 }}
*{{cite journal | author=Offermanns S, Schultz G, Rosenthal W |title=Evidence for opioid receptor-mediated activation of the G-proteins, Go and Gi2, in membranes of neuroblastoma x glioma (NG108-15) hybrid cells. |journal=J. Biol. Chem. |volume=266 |issue= 6 |pages= 3365-8 |year= 1991 |pmid= 1671672 |doi=  }}
* {{cite journal | vauthors = Bushfield M, Murphy GJ, Lavan BE, Parker PJ, Hruby VJ, Milligan G, Houslay MD | title = Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes | journal = The Biochemical Journal | volume = 268 | issue = 2 | pages = 449–57  | date = Jun 1990 | pmid = 2114093 | pmc = 1131453 | doi =  }}
*{{cite journal | author=Cormont M, Le Marchand-Brustel Y, Van Obberghen E, ''et al.'' |title=Identification of G protein alpha-subunits in RINm5F cells and their selective interaction with galanin receptor. |journal=Diabetes |volume=40 |issue= 9 |pages= 1170-6 |year= 1991 |pmid= 1718802 |doi= }}
* {{cite journal | vauthors = Lyons J, Landis CA, Harsh G, Vallar L, Grünewald K, Feichtinger H, Duh QY, Clark OH, Kawasaki E, Bourne HR | title = Two G protein oncogenes in human endocrine tumors | journal = Science | volume = 249 | issue = 4969 | pages = 655–9  | date = Aug 1990 | pmid = 2116665 | doi = 10.1126/science.2116665 }}
*{{cite journal | author=Magovcevic I, Ang SL, Seidman JG, ''et al.'' |title=Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13. |journal=Genomics |volume=12 |issue= 1 |pages= 125-9 |year= 1992 |pmid= 1733849 |doi=  }}
* {{cite journal | vauthors = Osawa S, Dhanasekaran N, Woon CW, Johnson GL | title = G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions | journal = Cell | volume = 63 | issue = 4 | pages = 697–706  | date = Nov 1990 | pmid = 2121366 | doi = 10.1016/0092-8674(90)90136-3 }}
*{{cite journal | author=Bushfield M, Murphy GJ, Lavan BE, ''et al.'' |title=Hormonal regulation of Gi2 alpha-subunit phosphorylation in intact hepatocytes. |journal=Biochem. J. |volume=268 |issue= 2 |pages= 449-57 |year= 1990 |pmid= 2114093 |doi= }}
* {{cite journal | vauthors = McClue SJ, Milligan G | title = The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2 | journal = FEBS Letters | volume = 269 | issue = 2 | pages = 430–4  | date = Sep 1990 | pmid = 2169434 | doi = 10.1016/0014-5793(90)81209-7 }}
*{{cite journal | author=Lyons J, Landis CA, Harsh G, ''et al.'' |title=Two G protein oncogenes in human endocrine tumors. |journal=Science |volume=249 |issue= 4969 |pages= 655-9 |year= 1990 |pmid= 2116665 |doi= }}
* {{cite journal | vauthors = Rudolph U, Koesling D, Hinsch KD, Seifert R, Bigalke M, Schultz G, Rosenthal W | title = G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils | journal = Molecular and Cellular Endocrinology | volume = 63 | issue = 1-2 | pages = 143–53  | date = May 1989 | pmid = 2502457 | doi = 10.1016/0303-7207(89)90090-7 }}
*{{cite journal | author=Osawa S, Dhanasekaran N, Woon CW, Johnson GL |title=G alpha i-G alpha s chimeras define the function of alpha chain domains in control of G protein activation and beta gamma subunit complex interactions. |journal=Cell |volume=63 |issue= 4 |pages= 697-706 |year= 1990 |pmid= 2121366 |doi= }}
* {{cite journal | vauthors = Lang JC, Costa T | title = Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o | journal = Journal of Receptor Research | volume = 9 | issue = 4-5 | pages = 313–29 | year = 1990 | pmid = 2512386 | doi =  }}
*{{cite journal | author=McClue SJ, Milligan G |title=The alpha 2B adrenergic receptor of undifferentiated neuroblastoma x glioma hybrid NG108-15 cells, interacts directly with the guanine nucleotide binding protein, Gi2. |journal=FEBS Lett. |volume=269 |issue= 2 |pages= 430-4 |year= 1990 |pmid= 2169434 |doi= }}
* {{cite journal | vauthors = Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y | title = Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs | journal = The Journal of Biological Chemistry | volume = 263 | issue = 14 | pages = 6656–64  | date = May 1988 | pmid = 2834384 | doi =  }}
*{{cite journal | author=Rudolph U, Koesling D, Hinsch KD, ''et al.'' |title=G-protein alpha-subunits in cytosolic and membranous fractions of human neutrophils. |journal=Mol. Cell. Endocrinol. |volume=63 |issue= 1-2 |pages= 143-53 |year= 1989 |pmid= 2502457 |doi=  }}
* {{cite journal | vauthors = Weinstein LS, Spiegel AM, Carter AD | title = Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein | journal = FEBS Letters | volume = 232 | issue = 2 | pages = 333–40  | date = May 1988 | pmid = 2837412 | doi = 10.1016/0014-5793(88)80764-6 }}
*{{cite journal | author=Lang JC, Costa T |title=Distribution of the alpha-subunit of the guanine nucleotide-binding protein Gi2 and its comparison to G alpha o. |journal=J. Recept. Res. |volume=9 |issue= 4-5 |pages= 313-29 |year= 1990 |pmid= 2512386 |doi=  }}
* {{cite journal | vauthors = Beals CR, Wilson CB, Perlmutter RM | title = A small multigene family encodes Gi signal-transduction proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 22 | pages = 7886–90  | date = Nov 1987 | pmid = 3120178 | pmc = 299440 | doi = 10.1073/pnas.84.22.7886 }}
*{{cite journal | author=Itoh H, Toyama R, Kozasa T, ''et al.'' |title=Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. |journal=J. Biol. Chem. |volume=263 |issue= 14 |pages= 6656-64 |year= 1988 |pmid= 2834384 |doi= }}
* {{cite journal | vauthors = Williamson EA, Ince PG, Harrison D, Kendall-Taylor P, Harris PE | title = G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas | journal = European Journal of Clinical Investigation | volume = 25 | issue = 2 | pages = 128–31  | date = Feb 1995 | pmid = 7737262 | doi = 10.1111/j.1365-2362.1995.tb01537.x }}
*{{cite journal | author=Weinstein LS, Spiegel AM, Carter AD |title=Cloning and characterization of the human gene for the alpha-subunit of Gi2, a GTP-binding signal transduction protein. |journal=FEBS Lett. |volume=232 |issue= 2 |pages= 333-40 |year= 1988 |pmid= 2837412 |doi= }}
* {{cite journal | vauthors = Takigawa M, Sakurai T, Kasuya Y, Abe Y, Masaki T, Goto K | title = Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors | journal = European Journal of Biochemistry / FEBS | volume = 228 | issue = 1 | pages = 102–8  | date = Feb 1995 | pmid = 7882989 | doi = 10.1111/j.1432-1033.1995.tb20236.x }}
*{{cite journal | author=Didsbury JR, Ho YS, Snyderman R |title=Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA. |journal=FEBS Lett. |volume=211 |issue= 2 |pages= 160-4 |year= 1987 |pmid= 3100330 |doi= }}
* {{cite journal | vauthors = Grassie MA, Milligan G | title = Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts | journal = The Biochemical Journal | volume = 306 | issue = 2 | pages = 525–30  | date = Mar 1995 | pmid = 7887906 | pmc = 1136549 | doi =  10.1042/bj3060525}}
*{{cite journal | author=Beals CR, Wilson CB, Perlmutter RM |title=A small multigene family encodes Gi signal-transduction proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 7886-90 |year= 1987 |pmid= 3120178 |doi= }}
* {{cite journal | vauthors = Migeon JC, Thomas SL, Nathanson NM | title = Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha | journal = The Journal of Biological Chemistry | volume = 269 | issue = 46 | pages = 29146–52  | date = Nov 1994 | pmid = 7961880 | doi =  }}
*{{cite journal | author=Williamson EA, Ince PG, Harrison D, ''et al.'' |title=G-protein mutations in human pituitary adrenocorticotrophic hormone-secreting adenomas. |journal=Eur. J. Clin. Invest. |volume=25 |issue= 2 |pages= 128-31 |year= 1995 |pmid= 7737262 |doi=  }}
* {{cite journal | vauthors = Wennogle LP, Conder L, Winter C, Braunwalder A, Vlattas S, Kramer R, Cioffi C, Hu SI | title = Stabilization of C5a receptor--G-protein interactions through ligand binding | journal = Journal of Cellular Biochemistry | volume = 55 | issue = 3 | pages = 380–8  | date = Jul 1994 | pmid = 7962171 | doi = 10.1002/jcb.240550316 }}
*{{cite journal | author=Takigawa M, Sakurai T, Kasuya Y, ''et al.'' |title=Molecular identification of guanine-nucleotide-binding regulatory proteins which couple to endothelin receptors. |journal=Eur. J. Biochem. |volume=228 |issue= 1 |pages= 102-8 |year= 1995 |pmid= 7882989 |doi=  }}
* {{cite journal | vauthors = Valet P, Senard JM, Devedjian JC, Planat V, Salomon R, Voisin T, Drean G, Couvineau A, Daviaud D, Denis C | title = Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa | journal = The Journal of Clinical Investigation | volume = 91 | issue = 5 | pages = 2049–57  | date = May 1993 | pmid = 8098045 | pmc = 288203 | doi = 10.1172/JCI116427 }}
*{{cite journal | author=Grassie MA, Milligan G |title=Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts. |journal=Biochem. J. |volume=306 ( Pt 2) |issue= |pages= 525-30 |year= 1995 |pmid= 7887906 |doi= }}
*{{cite journal | author=Migeon JC, Thomas SL, Nathanson NM |title=Regulation of cAMP-mediated gene transcription by wild type and mutated G-protein alpha subunits. Inhibition of adenylyl cyclase activity by muscarinic receptor-activated and constitutively activated G(o) alpha. |journal=J. Biol. Chem. |volume=269 |issue= 46 |pages= 29146-52 |year= 1994 |pmid= 7961880 |doi= }}
*{{cite journal  | author=Wennogle LP, Conder L, Winter C, ''et al.'' |title=Stabilization of C5a receptor--G-protein interactions through ligand binding. |journal=J. Cell. Biochem. |volume=55 |issue= 3 |pages= 380-8 |year= 1994 |pmid= 7962171 |doi= 10.1002/jcb.240550316 }}
*{{cite journal  | author=Valet P, Senard JM, Devedjian JC, ''et al.'' |title=Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa. |journal=J. Clin. Invest. |volume=91 |issue= 5 |pages= 2049-57 |year= 1993 |pmid= 8098045 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Intracellular signaling peptides and proteins}}
{{GTPases}}
{{GTPases}}
{{WikiDoc Sources}}

Latest revision as of 08:50, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene.[1][2][3]

Interactions

GNAI2 has been shown to interact with:

References

  1. ↑ Didsbury JR, Ho YS, Snyderman R (Jan 1987). "Human Gi protein alpha-subunit: deduction of amino acid structure from a cloned cDNA". FEBS Letters. 211 (2): 160–4. doi:10.1016/0014-5793(87)81428-X. PMID 3100330.
  2. ↑ Magovcevic I, Ang SL, Seidman JG, Tolman CJ, Neer EJ, Morton CC (Jan 1992). "Regional localization of the human G protein alpha i2 (GNAI2) gene: assignment to 3p21 and a related sequence (GNAI2L) to 12p12-p13". Genomics. 12 (1): 125–9. doi:10.1016/0888-7543(92)90414-N. PMID 1733849.
  3. ↑ "Entrez Gene: GNAI2 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2".
  4. ↑ Fan X, Brass LF, Poncz M, Spitz F, Maire P, Manning DR (Oct 2000). "The alpha subunits of Gz and Gi interact with the eyes absent transcription cofactor Eya2, preventing its interaction with the six class of homeodomain-containing proteins". The Journal of Biological Chemistry. 275 (41): 32129–34. doi:10.1074/jbc.M004577200. PMID 10906137.
  5. ↑ Marty C, Browning DD, Ye RD (Jun 2003). "Identification of tetratricopeptide repeat 1 as an adaptor protein that interacts with heterotrimeric G proteins and the small GTPase Ras". Molecular and Cellular Biology. 23 (11): 3847–58. doi:10.1128/mcb.23.11.3847-3858.2003. PMC 155206. PMID 12748287.
  6. ↑ Mochizuki N, Cho G, Wen B, Insel PA (Nov 1996). "Identification and cDNA cloning of a novel human mosaic protein, LGN, based on interaction with G alpha i2". Gene. 181 (1–2): 39–43. doi:10.1016/s0378-1119(96)00456-8. PMID 8973305.
  7. ↑ Damaj BB, McColl SR, Neote K, Songqing N, Ogborn KT, Hébert CA, Naccache PH (Oct 1996). "Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops". FASEB Journal. 10 (12): 1426–34. PMID 8903513.
  8. ↑ Damaj BB, McColl SR, Mahana W, Crouch MF, Naccache PH (May 1996). "Physical association of Gi2alpha with interleukin-8 receptors". The Journal of Biological Chemistry. 271 (22): 12783–9. doi:10.1074/jbc.271.22.12783. PMID 8662698.
  9. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
  10. ↑ Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  11. ↑ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162.
  12. ↑ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.

Further reading

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