UBE2E1: Difference between revisions
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{{ | '''Ubiquitin-conjugating enzyme E2 E1''' is a [[protein]] that in humans is encoded by the ''UBE2E1'' [[gene]].<ref name="pmid8576257">{{cite journal | vauthors = Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M | title = Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5 | journal = J. Biol. Chem. | volume = 271 | issue = 5 | pages = 2795–800 | date = Mar 1996 | pmid = 8576257 | pmc = | doi = 10.1074/jbc.271.5.2795 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7324| accessdate = }}</ref> | ||
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== Function == | |||
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.<ref name="entrez" /> | |||
==References== | == Interactions == | ||
{{reflist | |||
==Further reading== | UBE2E1 has been shown to [[Protein-protein interaction|interact]] with [[Ataxin 1]]<ref name=pmid18439907>{{cite journal | vauthors = Hong S, Lee S, Cho SG, Kang S | title = UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1 | journal = Biochem. Biophys. Res. Commun. | volume = 371 | issue = 2 | pages = 256–60 | date = Jun 2008 | pmid = 18439907 | doi = 10.1016/j.bbrc.2008.04.066 }}</ref> and [[NEDD4]].<ref name=pmid9990509>{{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes Cells | volume = 3 | issue = 11 | pages = 751–63 | date = Nov 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x }}</ref><ref name=pmid18287095>{{cite journal | vauthors = Malakhova OA, Zhang DE | title = ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response | journal = J. Biol. Chem. | volume = 283 | issue = 14 | pages = 8783–7 | date = Apr 2008 | pmid = 18287095 | pmc = 2276364 | doi = 10.1074/jbc.C800030200 }}</ref> | ||
== References == | |||
{{reflist}} | |||
== Further reading == | |||
{{refbegin | 2}} | {{refbegin | 2}} | ||
* {{cite journal | vauthors = Pickart CM | title = Mechanisms underlying ubiquitination | journal = Annu. Rev. Biochem. | volume = 70 | issue = | pages = 503–33 | year = 2001 | pmid = 11395416 | doi = 10.1146/annurev.biochem.70.1.503 }} | |||
* {{cite journal | vauthors = Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M | title = Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor | journal = Cell | volume = 74 | issue = 2 | pages = 357–69 | year = 1993 | pmid = 8393731 | doi = 10.1016/0092-8674(93)90426-Q }} | |||
*{{cite journal | * {{cite journal | vauthors = Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M | title = Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes | journal = Genes Cells | volume = 3 | issue = 11 | pages = 751–63 | year = 1998 | pmid = 9990509 | doi = 10.1046/j.1365-2443.1998.00227.x }} | ||
*{{cite journal | * {{cite journal | vauthors = Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N | title = Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes | journal = Eur. J. Biochem. | volume = 267 | issue = 13 | pages = 4011–9 | year = 2000 | pmid = 10866800 | doi = 10.1046/j.1432-1327.2000.01433.x }} | ||
* {{cite journal | vauthors = Lenk U, Sommer T | title = Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization | journal = J. Biol. Chem. | volume = 275 | issue = 50 | pages = 39403–10 | year = 2000 | pmid = 10991948 | doi = 10.1074/jbc.M006949200 }} | |||
*{{cite journal | * {{cite journal | vauthors = Pringa E, Martinez-Noel G, Muller U, Harbers K | title = Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes | journal = J. Biol. Chem. | volume = 276 | issue = 22 | pages = 19617–23 | year = 2001 | pmid = 11274149 | doi = 10.1074/jbc.M100192200 }} | ||
*{{cite journal | * {{cite journal | vauthors = Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y | title = N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8 | journal = Eur. J. Biochem. | volume = 268 | issue = 9 | pages = 2725–32 | year = 2001 | pmid = 11322894 | doi = 10.1046/j.1432-1327.2001.02169.x }} | ||
*{{cite journal | * {{cite journal | vauthors = Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM | title = Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region | journal = Genomics | volume = 83 | issue = 1 | pages = 153–67 | year = 2004 | pmid = 14667819 | doi = 10.1016/S0888-7543(03)00235-0 }} | ||
*{{cite journal | * {{cite journal | vauthors = Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H | title = Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme | journal = J. Biochem. | volume = 138 | issue = 6 | pages = 711–9 | year = 2005 | pmid = 16428300 | doi = 10.1093/jb/mvi172 }} | ||
*{{cite journal | |||
*{{cite journal | |||
*{{cite journal | |||
}} | |||
{{refend}} | {{refend}} | ||
{{ | {{PDB Gallery|geneid=7324}} | ||
{{ | {{Ubiquitin-conjugating enzymes}} | ||
{{gene-3-stub}} |
Latest revision as of 03:19, 27 October 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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UniProt |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[1][2]
Function
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]
Interactions
UBE2E1 has been shown to interact with Ataxin 1[3] and NEDD4.[4][5]
References
- ↑ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257.
- ↑ 2.0 2.1 "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)".
- ↑ Hong S, Lee S, Cho SG, Kang S (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907.
- ↑ Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
- ↑ Malakhova OA, Zhang DE (Apr 2008). "ISG15 inhibits Nedd4 ubiquitin E3 activity and enhances the innate antiviral response". J. Biol. Chem. 283 (14): 8783–7. doi:10.1074/jbc.C800030200. PMC 2276364. PMID 18287095.
Further reading
- Pickart CM (2001). "Mechanisms underlying ubiquitination". Annu. Rev. Biochem. 70: 503–33. doi:10.1146/annurev.biochem.70.1.503. PMID 11395416.
- Chen P, Johnson P, Sommer T, Jentsch S, Hochstrasser M (1993). "Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor". Cell. 74 (2): 357–69. doi:10.1016/0092-8674(93)90426-Q. PMID 8393731.
- Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells. 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. PMID 9990509.
- Nyman TA, Matikainen S, Sareneva T, Julkunen I, Kalkkinen N (2000). "Proteome analysis reveals ubiquitin-conjugating enzymes to be a new family of interferon-alpha-regulated genes". Eur. J. Biochem. 267 (13): 4011–9. doi:10.1046/j.1432-1327.2000.01433.x. PMID 10866800.
- Lenk U, Sommer T (2000). "Ubiquitin-mediated proteolysis of a short-lived regulatory protein depends on its cellular localization". J. Biol. Chem. 275 (50): 39403–10. doi:10.1074/jbc.M006949200. PMID 10991948.
- Pringa E, Martinez-Noel G, Muller U, Harbers K (2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149.
- Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). "N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8". Eur. J. Biochem. 268 (9): 2725–32. doi:10.1046/j.1432-1327.2001.02169.x. PMID 11322894.
- Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region". Genomics. 83 (1): 153–67. doi:10.1016/S0888-7543(03)00235-0. PMID 14667819.
- Takeuchi T, Iwahara S, Saeki Y, Sasajima H, Yokosawa H (2005). "Link between the ubiquitin conjugation system and the ISG15 conjugation system: ISG15 conjugation to the UbcH6 ubiquitin E2 enzyme". J. Biochem. 138 (6): 711–9. doi:10.1093/jb/mvi172. PMID 16428300.
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