EPHA6: Difference between revisions

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Ephrin type-A receptor 6 is a protein that in humans is encoded by the EPHA6 gene.^[1]^[2]

References

↑ Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.
↑ "Entrez Gene: EPHA6 EPH receptor A6".

Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly". Int. Rev. Cytol. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. PMID 10730216.
Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC 1692797. PMID 11128993.
Nakamoto T, Kain KH, Ginsberg MH (2004). "Neurobiology: New connections between integrins and axon guidance". Curr. Biol. 14 (3): R121–3. doi:10.1016/j.cub.2004.01.020. PMID 14986683.
Yamaguchi Y, Pasquale EB (2004). "Eph receptors in the adult brain". Curr. Opin. Neurobiol. 14 (3): 288–96. doi:10.1016/j.conb.2004.04.003. PMID 15194108.
Murai KK, Pasquale EB (2004). "Eph receptors, ephrins, and synaptic function". The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry. 10 (4): 304–14. doi:10.1177/1073858403262221. PMID 15271258.
Gale NW, Holland SJ, Valenzuela DM, et al. (1996). "Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis". Neuron. 17 (1): 9–19. doi:10.1016/S0896-6273(00)80276-7. PMID 8755474.
Aasheim HC, Munthe E, Funderud S, et al. (2000). "A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes". Blood. 95 (1): 221–30. PMID 10607706.
Prevost N, Woulfe D, Tanaka T, Brass LF (2002). "Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred". Proc. Natl. Acad. Sci. U.S.A. 99 (14): 9219–24. doi:10.1073/pnas.142053899. PMC 123121. PMID 12084815.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Hafner C, Schmitz G, Meyer S, et al. (2004). "Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers". Clin. Chem. 50 (3): 490–9. doi:10.1373/clinchem.2003.026849. PMID 14726470.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[pmid12471243-1] Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (Dec 2002). "The protein kinase complement of the human genome". Science. 298 (5600): 1912–34. doi:10.1126/science.1075762. PMID 12471243.

[entrez-2] "Entrez Gene: EPHA6 EPH receptor A6".

[1]

[2]

@@ Line 1: / Line 1: @@
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+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Ephrin type-A receptor 6''' is a [[protein]] that in humans is encoded by the ''EPHA6'' [[gene]].<ref name="pmid12471243">{{cite journal | vauthors = Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S | title = The protein kinase complement of the human genome | journal = Science | volume = 298 | issue = 5600 | pages = 1912–34 |date=Dec 2002 | pmid = 12471243 | pmc =  | doi = 10.1126/science.1075762 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPHA6 EPH receptor A6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285220| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = EPH receptor A6
- | HGNCid = 19296
- | Symbol = EPHA6
- | AltSymbols =; DKFZp434C1418; EPA6; FLJ35246; PRO57066
- | OMIM =
- | ECnumber =
- | Homologene = 56396
- | MGIid = 108034
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004713 |text = protein-tyrosine kinase activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 285220
-    | Hs_Ensembl = ENSG00000080224
-    | Hs_RefseqProtein = XP_001126591
-    | Hs_RefseqmRNA = XM_001126591
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 3
-    | Hs_GenLoc_start = 98016311
-    | Hs_GenLoc_end = 98950232
-    | Hs_Uniprot = Q9UF33
-    | Mm_EntrezGene = 13840
-    | Mm_Ensembl = ENSMUSG00000055540
-    | Mm_RefseqmRNA = NM_007938
-    | Mm_RefseqProtein = NP_031964
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 16
-    | Mm_GenLoc_start = 59596276
-    | Mm_GenLoc_end = 60547219
-    | Mm_Uniprot = Q3V2Z8
-  }}
-}}
-'''EPH receptor A6''', also known as '''EPHA6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPHA6 EPH receptor A6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=285220| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 54: / Line 10: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177-244 |year= 2000 |pmid= 10730216 |doi=  }}
+*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=10.1016/S0074-7696(00)96005-4  }}
-*{{cite journal  | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
+*{{cite journal  | vauthors=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635  | pmc=1692797 }}
-*{{cite journal  | author=Manning G, Whyte DB, Martinez R, ''et al.'' |title=The protein kinase complement of the human genome. |journal=Science |volume=298 |issue= 5600 |pages= 1912-34 |year= 2003 |pmid= 12471243 |doi= 10.1126/science.1075762 }}
+*{{cite journal  | vauthors=Nakamoto T, Kain KH, Ginsberg MH |title=Neurobiology: New connections between integrins and axon guidance. |journal=Curr. Biol. |volume=14 |issue= 3 |pages= R121–3 |year= 2004 |pmid= 14986683 |doi=  10.1016/j.cub.2004.01.020}}
-*{{cite journal  | author=Nakamoto T, Kain KH, Ginsberg MH |title=Neurobiology: New connections between integrins and axon guidance. |journal=Curr. Biol. |volume=14 |issue= 3 |pages= R121-3 |year= 2004 |pmid= 14986683 |doi=  }}
+*{{cite journal  | vauthors=Yamaguchi Y, Pasquale EB |title=Eph receptors in the adult brain. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 288–96 |year= 2004 |pmid= 15194108 |doi= 10.1016/j.conb.2004.04.003 }}
-*{{cite journal  | author=Yamaguchi Y, Pasquale EB |title=Eph receptors in the adult brain. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 288-96 |year= 2004 |pmid= 15194108 |doi= 10.1016/j.conb.2004.04.003 }}
+*{{cite journal  | vauthors=Murai KK, Pasquale EB |title=Eph receptors, ephrins, and synaptic function. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 4 |pages= 304–14 |year= 2004 |pmid= 15271258 |doi= 10.1177/1073858403262221 }}
-*{{cite journal  | author=Murai KK, Pasquale EB |title=Eph receptors, ephrins, and synaptic function. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 4 |pages= 304-14 |year= 2004 |pmid= 15271258 |doi= 10.1177/1073858403262221 }}
+*{{cite journal  | vauthors=Gale NW, Holland SJ, Valenzuela DM |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=10.1016/S0896-6273(00)80276-7  |display-authors=etal}}
-*{{cite journal  | author=Gale NW, Holland SJ, Valenzuela DM, ''et al.'' |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9-19 |year= 1996 |pmid= 8755474 |doi=  }}
+*{{cite journal  | vauthors=Aasheim HC, Munthe E, Funderud S |title=A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. |journal=Blood |volume=95 |issue= 1 |pages= 221–30 |year= 2000 |pmid= 10607706 |doi=  |display-authors=etal}}
-*{{cite journal  | author=Aasheim HC, Munthe E, Funderud S, ''et al.'' |title=A splice variant of human ephrin-A4 encodes a soluble molecule that is secreted by activated human B lymphocytes. |journal=Blood |volume=95 |issue= 1 |pages= 221-30 |year= 2000 |pmid= 10607706 |doi=  }}
+*{{cite journal  | vauthors=Prevost N, Woulfe D, Tanaka T, Brass LF |title=Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 14 |pages= 9219–24 |year= 2002 |pmid= 12084815 |doi= 10.1073/pnas.142053899  | pmc=123121 }}
-*{{cite journal  | author=Prevost N, Woulfe D, Tanaka T, Brass LF |title=Interactions between Eph kinases and ephrins provide a mechanism to support platelet aggregation once cell-to-cell contact has occurred. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 14 |pages= 9219-24 |year= 2002 |pmid= 12084815 |doi= 10.1073/pnas.142053899 }}
+*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Clark HF, Gurney AL, Abaya E |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003  | pmc=403697 |display-authors=etal}}
-*{{cite journal  | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
+*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | vauthors=Hafner C, Schmitz G, Meyer S |title=Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. |journal=Clin. Chem. |volume=50 |issue= 3 |pages= 490–9 |year= 2004 |pmid= 14726470 |doi= 10.1373/clinchem.2003.026849 |display-authors=etal}}
-*{{cite journal  | author=Hafner C, Schmitz G, Meyer S, ''et al.'' |title=Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. |journal=Clin. Chem. |volume=50 |issue= 3 |pages= 490-9 |year= 2004 |pmid= 14726470 |doi= 10.1373/clinchem.2003.026849 }}
+*{{cite journal  | vauthors=Kimura K, Wakamatsu A, Suzuki Y |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 |display-authors=etal}}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
 }}
 {{refend}}
-{{protein-stub}}
+{{Tyrosine kinases}}
-{{WikiDoc Sources}}
+{{Enzymes}}
+{{Growth factor receptor modulators}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:Tyrosine kinase receptors]]
+{{gene-3-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

EPHA6: Difference between revisions

Revision as of 05:02, 25 November 2017

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