SLC25A3: Difference between revisions

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Revision as of 06:29, 11 September 2017

Phosphate carrier protein, mitochondrial is a protein that in humans is encoded by the SLC25A3 gene.^[1]^[2]

The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.^[2]

References

↑ Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet. 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843.
↑ ^2.0 ^2.1 "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3".

Dolce V, Fiermonte G, Messina A, Palmieri F (1992). "Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier". DNA Seq. 2 (2): 133–5. doi:10.3109/10425179109039683. PMID 1777677.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Dolce V, Iacobazzi V, Palmieri F, Walker JE (1994). "The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms". J. Biol. Chem. 269 (14): 10451–60. PMID 8144629.
Marsh S, Carter NP, Dolce V, et al. (1996). "Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23". Genomics. 29 (3): 814–5. doi:10.1006/geno.1995.9924. PMID 8575787.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Huizing M, Ruitenbeek W, van den Heuvel LP, et al. (1999). "Human mitochondrial transmembrane metabolite carriers: tissue distribution and its implication for mitochondrial disorders". J. Bioenerg. Biomembr. 30 (3): 277–84. doi:10.1023/A:1020501021222. PMID 9733094.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. doi:10.1016/j.cub.2004.07.051. PMID 15324660.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Iacobazzi V, Infantino V, Costanzo P, et al. (2006). "Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors". Biochem. J. 391 (Pt 3): 613–21. doi:10.1042/BJ20050776. PMC 1276962. PMID 15984930.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Mayr JA, Merkel O, Kohlwein SD, et al. (2007). "Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation". Am. J. Hum. Genet. 80 (3): 478–84. doi:10.1086/511788. PMC 1821108. PMID 17273968.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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[pmid8168843-1] Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL (Jun 1994). "Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier". Hum Genet. 93 (5): 600–2. doi:10.1007/bf00202832. PMID 8168843.

[entrez-2] 2.0 ^2.1 "Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Phosphate carrier protein, mitochondrial''' is a [[protein]] that in humans is encoded by the ''SLC25A3'' [[gene]].<ref name="pmid8168843">{{cite journal | vauthors = Jabs EW, Thomas PJ, Bernstein M, Coss C, Ferreira GC, Pedersen PL | title = Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier | journal = Hum Genet | volume = 93 | issue = 5 | pages = 600–2 |date=Jun 1994 | pmid = 8168843 | pmc =  | doi =  10.1007/bf00202832}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5250| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3
- | HGNCid = 10989
- | Symbol = SLC25A3
- | AltSymbols =; OK/SW-cl.48; PHC
- | OMIM = 600370
- | ECnumber =
- | Homologene = 37649
- | MGIid = 1353498
- | Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0005488 |text = binding}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015320 |text = phosphate carrier activity}}
- | Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005743 |text = mitochondrial inner membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006810 |text = transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5250
-    | Hs_Ensembl = ENSG00000075415
-    | Hs_RefseqProtein = NP_998777
-    | Hs_RefseqmRNA = NM_213612
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 12
-    | Hs_GenLoc_start = 97511534
-    | Hs_GenLoc_end = 97519906
-    | Hs_Uniprot = Q00325
-    | Mm_EntrezGene = 18674
-    | Mm_Ensembl = ENSMUSG00000061904
-    | Mm_RefseqmRNA = NM_133668
-    | Mm_RefseqProtein = NP_598429
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 10
-    | Mm_GenLoc_start = 90546377
-    | Mm_GenLoc_end = 90553762
-    | Mm_Uniprot = Q3THU8
-  }}
-}}
-'''Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3''', also known as '''SLC25A3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5250| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton cotransport or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5250| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene catalyzes the transport of phosphate into the mitochondrial matrix, either by proton [[cotransport]] or in exchange for hydroxyl ions. The protein contains three related segments arranged in tandem which are related to those found in other characterized members of the mitochondrial carrier family. Both the N-terminal and C-terminal regions of this protein protrude toward the cytosol. Multiple alternatively spliced transcript variants have been isolated.<ref name="entrez">{{cite web | title = Entrez Gene: SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5250| accessdate = }}</ref>
 }}
@@ Line 57: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 63: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Dolce V, Fiermonte G, Messina A, Palmieri F |title=Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier. |journal=DNA Seq. |volume=2 |issue= 2 |pages= 133-5 |year= 1992 |pmid= 1777677 |doi=  }}
+*{{cite journal  | vauthors=Dolce V, Fiermonte G, Messina A, Palmieri F |title=Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier. |journal=DNA Seq. |volume=2 |issue= 2 |pages= 133–5 |year= 1992 |pmid= 1777677 |doi=10.3109/10425179109039683  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Dolce V, Iacobazzi V, Palmieri F, Walker JE |title=The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms. |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10451-60 |year= 1994 |pmid= 8144629 |doi=  }}
+*{{cite journal  | vauthors=Dolce V, Iacobazzi V, Palmieri F, Walker JE |title=The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms |journal=J. Biol. Chem. |volume=269 |issue= 14 |pages= 10451–60 |year= 1994 |pmid= 8144629 |doi=  }}
-*{{cite journal  | author=Jabs EW, Thomas PJ, Bernstein M, ''et al.'' |title=Chromosomal localization of genes required for the terminal steps of oxidative metabolism: alpha and gamma subunits of ATP synthase and the phosphate carrier. |journal=Hum. Genet. |volume=93 |issue= 5 |pages= 600-2 |year= 1994 |pmid= 8168843 |doi=  }}
+*{{cite journal   |vauthors=Marsh S, Carter NP, Dolce V, etal |title=Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23 |journal=Genomics |volume=29 |issue= 3 |pages= 814–5 |year= 1996 |pmid= 8575787 |doi= 10.1006/geno.1995.9924 }}
-*{{cite journal  | author=Marsh S, Carter NP, Dolce V, ''et al.'' |title=Chromosomal localization of the mitochondrial phosphate carrier gene PHC to 12q23. |journal=Genomics |volume=29 |issue= 3 |pages= 814-5 |year= 1996 |pmid= 8575787 |doi= 10.1006/geno.1995.9924 }}
+*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal   |vauthors=Huizing M, Ruitenbeek W, van den Heuvel LP, etal |title=Human mitochondrial transmembrane metabolite carriers: tissue distribution and its implication for mitochondrial disorders |journal=J. Bioenerg. Biomembr. |volume=30 |issue= 3 |pages= 277–84 |year= 1999 |pmid= 9733094 |doi=10.1023/A:1020501021222  }}
-*{{cite journal  | author=Huizing M, Ruitenbeek W, van den Heuvel LP, ''et al.'' |title=Human mitochondrial transmembrane metabolite carriers: tissue distribution and its implication for mitochondrial disorders. |journal=J. Bioenerg. Biomembr. |volume=30 |issue= 3 |pages= 277-84 |year= 1999 |pmid= 9733094 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
-*{{cite journal  | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
+*{{cite journal   |vauthors=Jin J, Smith FD, Stark C, etal |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
-*{{cite journal  | author=Jin J, Smith FD, Stark C, ''et al.'' |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436-50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
+*{{cite journal   |vauthors=Iacobazzi V, Infantino V, Costanzo P, etal |title=Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 613–21 |year= 2006 |pmid= 15984930 |doi= 10.1042/BJ20050776  | pmc=1276962 }}
-*{{cite journal  | author=Iacobazzi V, Infantino V, Costanzo P, ''et al.'' |title=Functional analysis of the promoter of the mitochondrial phosphate carrier human gene: identification of activator and repressor elements and their transcription factors. |journal=Biochem. J. |volume=391 |issue= Pt 3 |pages= 613-21 |year= 2006 |pmid= 15984930 |doi= 10.1042/BJ20050776 }}
+*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
+*{{cite journal   |vauthors=Mayr JA, Merkel O, Kohlwein SD, etal |title=Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation |journal=Am. J. Hum. Genet. |volume=80 |issue= 3 |pages= 478–84 |year= 2007 |pmid= 17273968 |doi= 10.1086/511788  | pmc=1821108 }}
-*{{cite journal  | author=Mayr JA, Merkel O, Kohlwein SD, ''et al.'' |title=Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation. |journal=Am. J. Hum. Genet. |volume=80 |issue= 3 |pages= 478-84 |year= 2007 |pmid= 17273968 |doi= 10.1086/511788 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC25A3: Difference between revisions

Revision as of 06:29, 11 September 2017

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References

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