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{{Infobox_gene}}
{{PBB_Controls
'''Zinc transporter 4''' is a [[protein]] that in humans is encoded by the ''SLC30A4'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7782| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 30 (zinc transporter), member 4
| HGNCid = 11015
| Symbol = SLC30A4
| AltSymbols =; ZNT4
| OMIM = 602095
| ECnumber = 
| Homologene = 74984
| MGIid = 1345282
| GeneAtlas_image1 = PBB_GE_SLC30A4_207362_at_tn.png
| Function = {{GNF_GO|id=GO:0005385 |text = zinc ion transmembrane transporter activity}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0008324 |text = cation transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}} {{GNF_GO|id=GO:0005768 |text = endosome}} {{GNF_GO|id=GO:0008021 |text = synaptic vesicle}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006812 |text = cation transport}} {{GNF_GO|id=GO:0006829 |text = zinc ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7782
    | Hs_Ensembl = ENSG00000104154
    | Hs_RefseqProtein = NP_037441
    | Hs_RefseqmRNA = NM_013309
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 15
    | Hs_GenLoc_start = 43561974
    | Hs_GenLoc_end = 43602294
    | Hs_Uniprot = O14863
    | Mm_EntrezGene = 22785
    | Mm_Ensembl = ENSMUSG00000005802
    | Mm_RefseqmRNA = NM_011774
    | Mm_RefseqProtein = NP_035904
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 122372680
    | Mm_GenLoc_end = 122394104
    | Mm_Uniprot = Q148S1
  }}
}}
'''Solute carrier family 30 (zinc transporter), member 4''', also known as '''SLC30A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7782| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Huang L, Gitschier J |title=A novel gene involved in zinc transport is deficient in the lethal milk mouse. |journal=Nat. Genet. |volume=17 |issue= 3 |pages= 292–7 |year= 1997 |pmid= 9354792 |doi= 10.1038/ng1197-292 }}
| citations =
*{{cite journal   |vauthors=Murgia C, Vespignani I, Cerase J, etal |title=Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 1 |pages= G1231–9 |year= 2000 |pmid= 10600821 |doi=  }}
*{{cite journal  | author=Huang L, Gitschier J |title=A novel gene involved in zinc transport is deficient in the lethal milk mouse. |journal=Nat. Genet. |volume=17 |issue= 3 |pages= 292-7 |year= 1997 |pmid= 9354792 |doi= 10.1038/ng1197-292 }}
*{{cite journal   |vauthors=Küry S, Devilder MC, Avet-Loiseau H, etal |title=Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica. |journal=Hum. Genet. |volume=109 |issue= 2 |pages= 178–85 |year= 2001 |pmid= 11511923 |doi=10.1007/s004390100539 }}
*{{cite journal | author=Murgia C, Vespignani I, Cerase J, ''et al.'' |title=Cloning, expression, and vesicular localization of zinc transporter Dri 27/ZnT4 in intestinal tissue and cells. |journal=Am. J. Physiol. |volume=277 |issue= 6 Pt 1 |pages= G1231-9 |year= 2000 |pmid= 10600821 |doi=  }}
*{{cite journal   |vauthors=Bleck O, Ashton GH, Mallipeddi R, etal |title=Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. |journal=Arch. Dermatol. Res. |volume=293 |issue= 8 |pages= 392–6 |year= 2002 |pmid= 11686514 |doi=10.1007/s004030100246 }}
*{{cite journal | author=Küry S, Devilder MC, Avet-Loiseau H, ''et al.'' |title=Expression pattern, genomic structure and evaluation of the human SLC30A4 gene as a candidate for acrodermatitis enteropathica. |journal=Hum. Genet. |volume=109 |issue= 2 |pages= 178-85 |year= 2001 |pmid= 11511923 |doi=  }}
*{{cite journal   |vauthors=Nakano A, Nakano H, Hanada K, etal |title=ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 201–2 |year= 2002 |pmid= 11935329 |doi= 10.1007/s00439-001-0661-7 }}
*{{cite journal | author=Bleck O, Ashton GH, Mallipeddi R, ''et al.'' |title=Genomic localization, organization and amplification of the human zinc transporter protein gene, ZNT4, and exclusion as a candidate gene in different clinical variants of acrodermatitis enteropathica. |journal=Arch. Dermatol. Res. |volume=293 |issue= 8 |pages= 392-6 |year= 2002 |pmid= 11686514 |doi=  }}
*{{cite journal  | vauthors=Michalczyk AA, Allen J, Blomeley RC, Ackland ML |title=Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells |journal=Biochem. J. |volume=364 |issue= Pt 1 |pages= 105–13 |year= 2002 |pmid= 11988082 |doi= | pmc=1222551 }}
*{{cite journal | author=Nakano A, Nakano H, Hanada K, ''et al.'' |title=ZNT4 gene is not responsible for acrodermatitis enteropathica in Japanese families. |journal=Hum. Genet. |volume=110 |issue= 2 |pages= 201-2 |year= 2002 |pmid= 11935329 |doi= 10.1007/s00439-001-0661-7 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Michalczyk AA, Allen J, Blomeley RC, Ackland ML |title=Constitutive expression of hZnT4 zinc transporter in human breast epithelial cells. |journal=Biochem. J. |volume=364 |issue= Pt 1 |pages= 105-13 |year= 2002 |pmid= 11988082 |doi=  }}
*{{cite journal   |vauthors=Michalczyk A, Varigos G, Catto-Smith A, etal |title=Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk |journal=Hum. Genet. |volume=113 |issue= 3 |pages= 202–10 |year= 2003 |pmid= 12743795 |doi= 10.1007/s00439-003-0952-2 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Henshall SM, Afar DE, Rasiah KK, etal |title=Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer |journal=Oncogene |volume=22 |issue= 38 |pages= 6005–12 |year= 2003 |pmid= 12955079 |doi= 10.1038/sj.onc.1206797 }}
*{{cite journal | author=Michalczyk A, Varigos G, Catto-Smith A, ''et al.'' |title=Analysis of zinc transporter, hZnT4 ( Slc30A4), gene expression in a mammary gland disorder leading to reduced zinc secretion into milk. |journal=Hum. Genet. |volume=113 |issue= 3 |pages= 202-10 |year= 2003 |pmid= 12743795 |doi= 10.1007/s00439-003-0952-2 }}
*{{cite journal   |vauthors=Beck FW, Prasad AS, Butler CE, etal |title=Differential expression of hZnT-4 in human prostate tissues |journal=Prostate |volume=58 |issue= 4 |pages= 374–81 |year= 2004 |pmid= 14968438 |doi= 10.1002/pros.10344 }}
*{{cite journal | author=Henshall SM, Afar DE, Rasiah KK, ''et al.'' |title=Expression of the zinc transporter ZnT4 is decreased in the progression from early prostate disease to invasive prostate cancer. |journal=Oncogene |volume=22 |issue= 38 |pages= 6005-12 |year= 2003 |pmid= 12955079 |doi= 10.1038/sj.onc.1206797 }}
*{{cite journal   |vauthors=Ho LH, Ruffin RE, Murgia C, etal |title=Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7750–60 |year= 2004 |pmid= 15187159 |doi=  10.4049/jimmunol.172.12.7750}}
*{{cite journal | author=Beck FW, Prasad AS, Butler CE, ''et al.'' |title=Differential expression of hZnT-4 in human prostate tissues. |journal=Prostate |volume=58 |issue= 4 |pages= 374-81 |year= 2004 |pmid= 14968438 |doi= 10.1002/pros.10344 }}
*{{cite journal  | vauthors=Smith JL, Xiong S, Markesbery WR, Lovell MA |title=Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain |journal=Neuroscience |volume=140 |issue= 3 |pages= 879–88 |year= 2006 |pmid= 16580781 |doi= 10.1016/j.neuroscience.2006.02.049 }}
*{{cite journal | author=Ho LH, Ruffin RE, Murgia C, ''et al.'' |title=Labile zinc and zinc transporter ZnT4 in mast cell granules: role in regulation of caspase activation and NF-kappaB translocation. |journal=J. Immunol. |volume=172 |issue= 12 |pages= 7750-60 |year= 2004 |pmid= 15187159 |doi=  }}
*{{cite journal  | author=Smith JL, Xiong S, Markesbery WR, Lovell MA |title=Altered expression of zinc transporters-4 and -6 in mild cognitive impairment, early and late Alzheimer's disease brain. |journal=Neuroscience |volume=140 |issue= 3 |pages= 879-88 |year= 2006 |pmid= 16580781 |doi= 10.1016/j.neuroscience.2006.02.049 }}
}}
{{refend}}
{{refend}}
{{Membrane transport proteins|bg|bg3}}
[[Category:Solute carrier family]]


{{membrane-protein-stub}}
{{membrane-protein-stub}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
{{WikiDoc Sources}}

Latest revision as of 06:31, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc transporter 4 is a protein that in humans is encoded by the SLC30A4 gene.[1]


See also

References

  1. ↑ "Entrez Gene: SLC30A4 solute carrier family 30 (zinc transporter), member 4".

Further reading


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