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{{Infobox_gene}}
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'''Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase''' is an [[enzyme]] that in humans is encoded by the ''PKMYT1'' [[gene]].<ref name="pmid9001210">{{cite journal |vauthors=Liu F, Stanton JJ, Wu Z, Piwnica-Worms H | title = The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex | journal = Mol Cell Biol | volume = 17 | issue = 2 | pages = 571–83 |date=Feb 1997 | pmid = 9001210 | pmc = 231782 | doi = 10.1128/mcb.17.2.571}}</ref><ref name="pmid12606722">{{cite journal |vauthors=Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A | title = The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase | journal = Proc Natl Acad Sci U S A | volume = 100 | issue = 5 | pages = 2284–9 |date=Mar 2003 | pmid = 12606722 | pmc = 151332 | doi = 10.1073/pnas.0530298100 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Protein kinase, membrane associated tyrosine/threonine 1
| HGNCid = 29650
| Symbol = PKMYT1
| AltSymbols =; MYT1; DKFZp547K1610; FLJ20093
| OMIM = 602474
| ECnumber =
| Homologene = 31227
| MGIid = 2137630
| GeneAtlas_image1 = PBB_GE_PKMYT1_204267_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0000079 |text = regulation of cyclin-dependent protein kinase activity}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9088
    | Hs_Ensembl = ENSG00000127564
    | Hs_RefseqProtein = NP_004194
    | Hs_RefseqmRNA = NM_004203
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 2962795
    | Hs_GenLoc_end = 2970475
    | Hs_Uniprot = Q99640
    | Mm_EntrezGene = 268930
    | Mm_Ensembl = ENSMUSG00000023908
    | Mm_RefseqmRNA = NM_023058
    | Mm_RefseqProtein = NP_075545
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 23454063
    | Mm_GenLoc_end = 23464364
    | Mm_Uniprot = Q3TNN2
  }}
}}
'''Protein kinase, membrane associated tyrosine/threonine 1''', also known as '''PKMYT1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = }}</ref>
| summary_text = The protein encoded by this gene is a member of the [[serine/threonine protein kinase]] family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. [[Protein kinase]]s AKT1/PKB and PLK ([[Polo-like kinase]]) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9088| accessdate = }}</ref>
}}
}}
==Interactions==
PKMYT1 has been shown to [[Protein-protein interaction|interact]] with [[PIN1]]<ref name=pmid9499405>{{cite journal |doi=10.1101/gad.12.5.706 |last=Shen |first=M |authorlink= |author2=Stukenberg P T |author3=Kirschner M W |author4=Lu K P  |date=Mar 1998 |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins |journal=Genes Dev. |volume=12 |issue=5 |pages=706–20 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9499405 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=316589 }}</ref> and [[STEAP3]].<ref name=pmid12606722 />


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Liu F, Stanton JJ, Wu Z, Piwnica-Worms H |title=The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex. |journal=Mol. Cell. Biol. |volume=17 |issue= 2 |pages= 571-83 |year= 1997 |pmid= 9001210 |doi=  }}
*{{cite journal  |vauthors=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=10.1074/jbc.272.35.22300 }}
*{{cite journal  | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300-6 |year= 1997 |pmid= 9268380 |doi=  }}
*{{cite journal  |vauthors=Shen M, Stukenberg PT, Kirschner MW, Lu KP |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 706–20 |year= 1998 |pmid= 9499405 |doi=10.1101/gad.12.5.706  | pmc=316589 }}
*{{cite journal  | author=Shen M, Stukenberg PT, Kirschner MW, Lu KP |title=The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins. |journal=Genes Dev. |volume=12 |issue= 5 |pages= 706-20 |year= 1998 |pmid= 9499405 |doi=  }}
*{{cite journal  |vauthors=Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H |title=Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5113–23 |year= 1999 |pmid= 10373560 |doi= | pmc=84354 }}
*{{cite journal  | author=Liu F, Rothblum-Oviatt C, Ryan CE, Piwnica-Worms H |title=Overproduction of human Myt1 kinase induces a G2 cell cycle delay by interfering with the intracellular trafficking of Cdc2-cyclin B1 complexes. |journal=Mol. Cell. Biol. |volume=19 |issue= 7 |pages= 5113-23 |year= 1999 |pmid= 10373560 |doi=  }}
*{{cite journal   |vauthors=Wells NJ, Watanabe N, Tokusumi T, etal |title=The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. |journal=J. Cell Sci. |volume=112 |issue=  19|pages= 3361–71 |year= 1999 |pmid= 10504341 |doi=  }}
*{{cite journal | author=Wells NJ, Watanabe N, Tokusumi T, ''et al.'' |title=The C-terminal domain of the Cdc2 inhibitory kinase Myt1 interacts with Cdc2 complexes and is required for inhibition of G(2)/M progression. |journal=J. Cell. Sci. |volume=112 ( Pt 19) |issue=  |pages= 3361-71 |year= 1999 |pmid= 10504341 |doi=  }}
*{{cite journal   |vauthors=Pathan N, Aime-Sempe C, Kitada S, etal |title=Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. |journal=Neoplasia |volume=3 |issue= 1 |pages= 70–9 |year= 2001 |pmid= 11326318 |doi= 10.1038/sj.neo.7900131 | pmc=1505024 }}
*{{cite journal | author=Pathan N, Aime-Sempe C, Kitada S, ''et al.'' |title=Microtubule-targeting drugs induce Bcl-2 phosphorylation and association with Pin1. |journal=Neoplasia |volume=3 |issue= 1 |pages= 70-9 |year= 2001 |pmid= 11326318 |doi= 10.1038/sj/neo/7900131 }}
*{{cite journal   |vauthors=Okumura E, Fukuhara T, Yoshida H, etal |title=Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 111–6 |year= 2002 |pmid= 11802161 |doi= 10.1038/ncb741 }}
*{{cite journal | author=Okumura E, Fukuhara T, Yoshida H, ''et al.'' |title=Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transition. |journal=Nat. Cell Biol. |volume=4 |issue= 2 |pages= 111-6 |year= 2002 |pmid= 11802161 |doi= 10.1038/ncb741 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E |title=Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25277–80 |year= 2003 |pmid= 12738781 |doi= 10.1074/jbc.C300126200 }}
*{{cite journal | author=Passer BJ, Nancy-Portebois V, Amzallag N, ''et al.'' |title=The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2284-9 |year= 2003 |pmid= 12606722 |doi= 10.1073/pnas.0530298100 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Nakajima H, Toyoshima-Morimoto F, Taniguchi E, Nishida E |title=Identification of a consensus motif for Plk (Polo-like kinase) phosphorylation reveals Myt1 as a Plk1 substrate. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25277-80 |year= 2003 |pmid= 12738781 |doi= 10.1074/jbc.C300126200 }}
*{{cite journal   |vauthors=Dai X, Yamasaki K, Yang L, etal |title=Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. |journal=J. Invest. Dermatol. |volume=122 |issue= 6 |pages= 1356–64 |year= 2004 |pmid= 15175024 |doi= 10.1111/j.0022-202X.2004.22522.x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Martin J, Han C, Gordon LA, etal |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988–94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal | author=Dai X, Yamasaki K, Yang L, ''et al.'' |title=Keratinocyte G2/M growth arrest by 1,25-dihydroxyvitamin D3 is caused by Cdc2 phosphorylation through Wee1 and Myt1 regulation. |journal=J. Invest. Dermatol. |volume=122 |issue= 6 |pages= 1356-64 |year= 2004 |pmid= 15175024 |doi= 10.1111/j.0022-202X.2004.22522.x }}
*{{cite journal  |vauthors=Bryan BA, Dyson OF, Akula SM |title=Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. |journal=J. Gen. Virol. |volume=87 |issue= Pt 3 |pages= 519–29 |year= 2006 |pmid= 16476973 |doi= 10.1099/vir.0.81603-0 }}
*{{cite journal | author=Martin J, Han C, Gordon LA, ''et al.'' |title=The sequence and analysis of duplication-rich human chromosome 16. |journal=Nature |volume=432 |issue= 7020 |pages= 988-94 |year= 2005 |pmid= 15616553 |doi= 10.1038/nature03187 }}
*{{cite journal   |vauthors=Nousiainen M, Silljé HH, Sauer G, etal |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal  | author=Bryan BA, Dyson OF, Akula SM |title=Identifying cellular genes crucial for the reactivation of Kaposi's sarcoma-associated herpesvirus latency. |journal=J. Gen. Virol. |volume=87 |issue= Pt 3 |pages= 519-29 |year= 2006 |pmid= 16476973 |doi= 10.1099/vir.0.81603-0 }}
*{{cite journal   |vauthors=Wissing J, Jänsch L, Nimtz M, etal |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell. Proteomics |volume=6 |issue= 3 |pages= 537–47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391-6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 }}
*{{cite journal | author=Wissing J, Jänsch L, Nimtz M, ''et al.'' |title=Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. |journal=Mol. Cell Proteomics |volume=6 |issue= 3 |pages= 537-47 |year= 2007 |pmid= 17192257 |doi= 10.1074/mcp.T600062-MCP200 }}
}}
}}
{{refend}}
{{refend}}


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[[Category:EC 2.7.11]]
 
 
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Revision as of 20:35, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase is an enzyme that in humans is encoded by the PKMYT1 gene.[1][2][3]

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase preferentially phosphorylates and inactivates cell division cycle 2 protein (CDC2), and thus negatively regulates cell cycle G2/M transition. This kinase is associated with the membrane throughout the cell cycle. Its activity is highly regulated during the cell cycle. Protein kinases AKT1/PKB and PLK (Polo-like kinase) have been shown to phosphorylate and regulate the activity of this kinase. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

Interactions

PKMYT1 has been shown to interact with PIN1[4] and STEAP3.[2]

References

  1. ↑ Liu F, Stanton JJ, Wu Z, Piwnica-Worms H (Feb 1997). "The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex". Mol Cell Biol. 17 (2): 571–83. doi:10.1128/mcb.17.2.571. PMC 231782. PMID 9001210.
  2. ↑ 2.0 2.1 Passer BJ, Nancy-Portebois V, Amzallag N, Prieur S, Cans C, Roborel de Climens A, Fiucci G, Bouvard V, Tuynder M, Susini L, Morchoisne S, Crible V, Lespagnol A, Dausset J, Oren M, Amson R, Telerman A (Mar 2003). "The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase". Proc Natl Acad Sci U S A. 100 (5): 2284–9. doi:10.1073/pnas.0530298100. PMC 151332. PMID 12606722.
  3. ↑ 3.0 3.1 "Entrez Gene: PKMYT1 protein kinase, membrane associated tyrosine/threonine 1".
  4. ↑ Shen, M; Stukenberg P T; Kirschner M W; Lu K P (Mar 1998). "The essential mitotic peptidyl-prolyl isomerase Pin1 binds and regulates mitosis-specific phosphoproteins". Genes Dev. UNITED STATES. 12 (5): 706–20. doi:10.1101/gad.12.5.706. ISSN 0890-9369. PMC 316589. PMID 9499405.

Further reading


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