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{{Infobox_gene}}
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'''Heat shock protein 75 kDa, mitochondrial''' is a [[protein]] that in humans is encoded by the ''TRAP1'' [[gene]].<ref name="pmid10652318">{{cite journal |vauthors=Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO | title = The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties | journal = J Biol Chem | volume = 275 | issue = 5 | pages = 3305–12 |date=March 2000 | pmid = 10652318 | pmc =  | doi =10.1074/jbc.275.5.3305 }}</ref><ref name="pmid7876093">{{cite journal |vauthors=Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB | title = Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor | journal = J Biol Chem | volume = 270 | issue = 8 | pages = 3574–81 |date=March 1995 | pmid = 7876093 | pmc =  | doi =10.1074/jbc.270.8.3574 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TRAP1 TNF receptor-associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10131| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = TNF receptor-associated protein 1
| HGNCid = 16264
| Symbol = TRAP1
| AltSymbols =; HSP75; HSP90L
| OMIM = 606219
| ECnumber =
| Homologene = 9457
| MGIid = 1915265
  | GeneAtlas_image1 = PBB_GE_TRAP1_201391_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0005164 |text = tumor necrosis factor receptor binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0051082 |text = unfolded protein binding}}
| Component = {{GNF_GO|id=GO:0005575 |text = cellular_component}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}}
  | Process = {{GNF_GO|id=GO:0006457 |text = protein folding}} {{GNF_GO|id=GO:0008150 |text = biological_process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10131
    | Hs_Ensembl = ENSG00000126602
    | Hs_RefseqProtein = NP_057376
    | Hs_RefseqmRNA = NM_016292
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 16
    | Hs_GenLoc_start = 3648040
    | Hs_GenLoc_end = 3707521
    | Hs_Uniprot = Q12931
    | Mm_EntrezGene = 68015
    | Mm_Ensembl = ENSMUSG00000005981
    | Mm_RefseqmRNA = NM_026508
    | Mm_RefseqProtein = NP_080784
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 16
    | Mm_GenLoc_start = 3955205
    | Mm_GenLoc_end = 3993038
    | Mm_Uniprot = Q3TK29
  }}
}}
'''TNF receptor-associated protein 1''', also known as '''TRAP1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TRAP1 TNF receptor-associated protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10131| accessdate = }}</ref>


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| summary_text =  
| summary_text =  
}}
}}
==Interactions==
TRAP1 has been shown to [[Protein-protein interaction|interact]] with [[EXT2 (gene)|EXT2]],<ref name=pmid10545594>{{cite journal |last=Simmons |first=A D |authorlink= |author2=Musy M M |author3=Lopes C S |author4=Hwang L Y |author5=Yang Y P |author6=Lovett M  |date=November 1999  |title=A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses |journal=Hum. Mol. Genet. |volume=8 |issue=12 |pages=2155–64 |publisher= |location = ENGLAND| issn = 0964-6906| pmid = 10545594 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1093/hmg/8.12.2155 }}</ref> [[EXT1]]<ref name=pmid10545594/> and [[Retinoblastoma protein]].<ref name=pmid8756626>{{cite journal |last=Chen |first=C F |authorlink= |author2=Chen Y |author3=Dai K |author4=Chen P L |author5=Riley D J |author6=Lee W H  |date=September 1996  |title=A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock |journal=Mol. Cell. Biol. |volume=16 |issue=9 |pages=4691–9 |publisher= |location = UNITED STATES| issn = 0270-7306| pmid = 8756626 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=231469 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Song HY, Dunbar JD, Zhang YX, ''et al.'' |title=Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor. |journal=J. Biol. Chem. |volume=270 |issue= 8 |pages= 3574-81 |year= 1995 |pmid= 7876093 |doi=  }}
*{{cite journal  |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Chen CF |title=A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4691–9 |year= 1996 |pmid= 8756626 |doi= | pmc=231469  |name-list-format=vanc| author2=Chen Y  | author3=Dai K  | display-authors=3  | last4=Chen  | first4=PL  | last5=Riley  | first5=DJ  | last6=Lee  | first6=WH }}
*{{cite journal  | author=Chen CF, Chen Y, Dai K, ''et al.'' |title=A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4691-9 |year= 1996 |pmid= 8756626 |doi=  }}
*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  |vauthors=Charng MJ, Zhang D, Kinnunen P, Schneider MD |title=A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9365–8 |year= 1998 |pmid= 9545258 |doi=10.1074/jbc.273.16.9365 }}
*{{cite journal  | author=Charng MJ, Zhang D, Kinnunen P, Schneider MD |title=A novel protein distinguishes between quiescent and activated forms of the type I transforming growth factor beta receptor. |journal=J. Biol. Chem. |volume=273 |issue= 16 |pages= 9365-8 |year= 1998 |pmid= 9545258 |doi=  }}
*{{cite journal  | author=Simmons AD |title=A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses |journal=Hum. Mol. Genet. |volume=8 |issue= 12 |pages= 2155–64 |year= 1999 |pmid= 10545594 |doi=10.1093/hmg/8.12.2155 |name-list-format=vanc| author2=Musy MM | author3=Lopes CS  | display-authors=3  | last4=Hwang  | first4=LY  | last5=Yang  | first5=YP  | last6=Lovett  | first6=M }}
*{{cite journal  | author=Simmons AD, Musy MM, Lopes CS, ''et al.'' |title=A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses. |journal=Hum. Mol. Genet. |volume=8 |issue= 12 |pages= 2155-64 |year= 1999 |pmid= 10545594 |doi=  }}
*{{cite journal  | author=Wurthner JU |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495–502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200 |name-list-format=vanc| author2=Frank DB  | author3=Felici A  | display-authors=3  | last4=Green  | first4=HM  | last5=Cao  | first5=Z  | last6=Schneider  | first6=MD  | last7=McNally  | first7=JG  | last8=Lechleider  | first8=RJ  | last9=Roberts  | first9=AB }}
*{{cite journal | author=Felts SJ, Owen BA, Nguyen P, ''et al.'' |title=The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3305-12 |year= 2000 |pmid= 10652318 |doi=  }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Wurthner JU, Frank DB, Felici A, ''et al.'' |title=Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19495-502 |year= 2001 |pmid= 11278302 |doi= 10.1074/jbc.M006473200 }}
*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Masuda Y |title=Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42503–15 |year= 2004 |pmid= 15292218 |doi= 10.1074/jbc.M404256200 |name-list-format=vanc| author2=Shima G  | author3=Aiuchi T  | display-authors=3  | last4=Horie  | first4=M  | last5=Hori  | first5=K  | last6=Nakajo  | first6=S  | last7=Kajimoto  | first7=S  | last8=Shibayama-Imazu  | first8=T  | last9=Nakaya  | first9=K }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Masuda Y, Shima G, Aiuchi T, ''et al.'' |title=Involvement of tumor necrosis factor receptor-associated protein 1 (TRAP1) in apoptosis induced by beta-hydroxyisovalerylshikonin. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42503-15 |year= 2004 |pmid= 15292218 |doi= 10.1074/jbc.M404256200 }}
*{{cite journal  | author=Brown V |title=Binding specificity of Toll-like receptor cytoplasmic domains |journal=Eur. J. Immunol. |volume=36 |issue= 3 |pages= 742–53 |year= 2006 |pmid= 16482509 |doi= 10.1002/eji.200535158 | pmc=2762736  |name-list-format=vanc| author2=Brown RA  | author3=Ozinsky A  | display-authors=3  | last4=Hesselberth  | first4=Jay R.  | last5=Fields  | first5=Stanley }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Im CN, Lee JS, Zheng Y, Seo JS |title=Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species |journal=J. Cell. Biochem. |volume=100 |issue= 2 |pages= 474–86 |year= 2007 |pmid= 16927372 |doi= 10.1002/jcb.21064 }}
*{{cite journal  | author=Brown V, Brown RA, Ozinsky A, ''et al.'' |title=Binding specificity of Toll-like receptor cytoplasmic domains. |journal=Eur. J. Immunol. |volume=36 |issue= 3 |pages= 742-53 |year= 2006 |pmid= 16482509 |doi= 10.1002/eji.200535158 }}
*{{cite journal  | author=Im CN, Lee JS, Zheng Y, Seo JS |title=Iron chelation study in a normal human hepatocyte cell line suggests that tumor necrosis factor receptor-associated protein 1 (TRAP1) regulates production of reactive oxygen species. |journal=J. Cell. Biochem. |volume=100 |issue= 2 |pages= 474-86 |year= 2007 |pmid= 16927372 |doi= 10.1002/jcb.21064 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* {{UCSC genome browser|TRAP1}}
* {{UCSC gene details|TRAP1}}
 
{{Chaperones}}
 
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Revision as of 12:14, 15 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Heat shock protein 75 kDa, mitochondrial is a protein that in humans is encoded by the TRAP1 gene.[1][2][3]


Interactions

TRAP1 has been shown to interact with EXT2,[4] EXT1[4] and Retinoblastoma protein.[5]

References

  1. ↑ Felts SJ, Owen BA, Nguyen P, Trepel J, Donner DB, Toft DO (March 2000). "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties". J Biol Chem. 275 (5): 3305–12. doi:10.1074/jbc.275.5.3305. PMID 10652318.
  2. ↑ Song HY, Dunbar JD, Zhang YX, Guo D, Donner DB (March 1995). "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor". J Biol Chem. 270 (8): 3574–81. doi:10.1074/jbc.270.8.3574. PMID 7876093.
  3. ↑ "Entrez Gene: TRAP1 TNF receptor-associated protein 1".
  4. ↑ 4.0 4.1 Simmons, A D; Musy M M; Lopes C S; Hwang L Y; Yang Y P; Lovett M (November 1999). "A direct interaction between EXT proteins and glycosyltransferases is defective in hereditary multiple exostoses". Hum. Mol. Genet. ENGLAND. 8 (12): 2155–64. doi:10.1093/hmg/8.12.2155. ISSN 0964-6906. PMID 10545594.
  5. ↑ Chen, C F; Chen Y; Dai K; Chen P L; Riley D J; Lee W H (September 1996). "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock". Mol. Cell. Biol. UNITED STATES. 16 (9): 4691–9. ISSN 0270-7306. PMC 231469. PMID 8756626.

Further reading

External links



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