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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Probable ATP-dependent RNA helicase DDX5''' also known as '''DEAD box protein 5''' or '''RNA helicase p68''' is an [[enzyme]] that in humans is encoded by the ''DDX5'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1655| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = DEAD (Asp-Glu-Ala-Asp) box polypeptide 5
| HGNCid = 2746
| Symbol = DDX5
| AltSymbols =; DKFZp686J01190; G17P1; HLR1; HUMP68; p68
| OMIM = 180630
| ECnumber = 
| Homologene = 74312
| MGIid = 105037
| GeneAtlas_image1 = PBB_GE_DDX5_200033_at_tn.png
| GeneAtlas_image2 = PBB_GE_DDX5_200034_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003724 |text = RNA helicase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008026 |text = ATP-dependent helicase activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0006397 |text = mRNA processing}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016049 |text = cell growth}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1655
    | Hs_Ensembl = ENSG00000108654
    | Hs_RefseqProtein = NP_004387
    | Hs_RefseqmRNA = NM_004396
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 59926202
    | Hs_GenLoc_end = 59932872
    | Hs_Uniprot = P17844
    | Mm_EntrezGene = 13207
    | Mm_Ensembl = ENSMUSG00000020719
    | Mm_RefseqmRNA = NM_007840
    | Mm_RefseqProtein = NP_031866
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 106596446
    | Mm_GenLoc_end = 106604584
    | Mm_Uniprot = O35662
  }}
}}
'''DEAD (Asp-Glu-Ala-Asp) box polypeptide 5''', also known as '''DDX5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1655| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[DEAD box]] proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative [[RNA helicase]]s. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
==Interactions==
| summary_text = DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1655| accessdate = }}</ref>
DDX5 has been shown to [[Protein-protein interaction|interact]] with:
}}
* [[AKAP8]],<ref name="pmid11279182">{{cite journal | vauthors = Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM | title = A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase | journal = J. Biol. Chem. | volume = 276 | issue = 20 | pages = 17448–54 |date=May 2001 | pmid = 11279182 | doi = 10.1074/jbc.M101171200 | url =  }}</ref>
*  [[DDX17]] (p72),<ref name="pmid12595555">{{cite journal | vauthors = Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV | title = The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells | journal = Nucleic Acids Res. | volume = 31 | issue = 5 | pages = 1470–80 |date=March 2003 | pmid = 12595555 | pmc = 149829 | doi = 10.1093/nar/gkg236 | url =  }}</ref>
* [[DHX9]] (RNA helicase A),<ref name="pmid18005418">{{cite journal | vauthors = Wilson BJ, Giguère V | title = Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis | journal = BMC Genomics | volume = 8| pages = 419 | year = 2007 | pmid = 18005418 | doi = 10.1186/1471-2164-8-419 | url = | pmc=3225811}}</ref>
* [[Estrogen receptor alpha]],<ref name="pmid10409727">{{cite journal | vauthors = Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S | title = Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α | journal = Mol. Cell. Biol. | volume = 19 | issue = 8 | pages = 5363–72 |date=August 1999 | pmid = 10409727 | pmc = 84379 | doi = | url =  }}</ref><ref name="pmid12527917">{{cite journal | vauthors = Rossow KL, Janknecht R | title = Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300 | journal = Oncogene | volume = 22 | issue = 1 | pages = 151–6 |date=January 2003 | pmid = 12527917 | doi = 10.1038/sj.onc.1206067 | url =  }}</ref>
* [[Fibrillarin]],<ref name="pmid10837141">{{cite journal | vauthors = Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV | title = The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase | journal = Exp. Cell Res. | volume = 257 | issue = 2 | pages = 272–80 |date=June 2000 | pmid = 10837141 | doi = 10.1006/excr.2000.4886 | url =  }}</ref>
* [[HDAC1]],<ref name="pmid15298701">{{cite journal | vauthors = Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV | title = The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner | journal = BMC Mol. Biol. | volume = 5| pages = 11 |date=August 2004 | pmid = 15298701 | pmc = 514542 | doi = 10.1186/1471-2199-5-11 | url = }}</ref>
* [[Nuclear receptor coactivator 1]],<ref name="pmid11250900">{{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama  K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1341–52 |date=March 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 | url =  }}</ref>
* [[Nuclear receptor coactivator 2]],<ref name=pmid11250900/>
* [[Nuclear receptor coactivator 3]],<ref name=pmid11250900/>
* [[p53]],<ref name="pmid15660129">{{cite journal | vauthors = Bates GJ, Nicol SM, Wilson BJ, Jacobs AM, Bourdon JC, Wardrop J, Gregory DJ, Lane DP, Perkins ND, Fuller-Pace FV | title = The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor | journal = EMBO J. | volume = 24 | issue = 3 | pages = 543–53 |date=February 2005 | pmid = 15660129 | pmc = 548656 | doi = 10.1038/sj.emboj.7600550 | url =  }}</ref>
* [[CTCF]].<ref name="pmid20966046">{{cite journal | vauthors = Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G | title = Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA | journal = Genes Dev | volume = 24 | issue = 22 | pages = 2543–2555 | year = 2010 |pmid = 20966046 | pmc = 2975930| doi = 10.1101/gad.1967810 | url =  }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Iggo RD, Jamieson DJ, MacNeill SA |title=p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1326–33 |year= 1991 |pmid= 1996094 |doi=  | pmc=369403  |display-authors=etal}}
| citations =
*{{cite journal  | vauthors=Hloch P, Schiedner G, Stahl H |title=Complete cDNA sequence of the human p68 protein |journal=Nucleic Acids Res. |volume=18 |issue= 10 |pages= 3045 |year= 1990 |pmid= 2349099 |doi=10.1093/nar/18.10.3045  | pmc=330836  }}
*{{cite journal  | author=Iggo RD, Jamieson DJ, MacNeill SA, ''et al.'' |title=p68 RNA helicase: identification of a nucleolar form and cloning of related genes containing a conserved intron in yeasts. |journal=Mol. Cell. Biol. |volume=11 |issue= 3 |pages= 1326-33 |year= 1991 |pmid= 1996094 |doi=  }}
*{{cite journal  | vauthors=Ford MJ, Anton IA, Lane DP |title=Nuclear protein with sequence homology to translation initiation factor eIF-4A |journal=Nature |volume=332 |issue= 6166 |pages= 736–8 |year= 1988 |pmid= 2451786 |doi= 10.1038/332736a0 }}
*{{cite journal  | author=Hloch P, Schiedner G, Stahl H |title=Complete cDNA sequence of the human p68 protein. |journal=Nucleic Acids Res. |volume=18 |issue= 10 |pages= 3045 |year= 1990 |pmid= 2349099 |doi= }}
*{{cite journal  | vauthors=Iggo R, Gough A, Xu W |title=Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 16 |pages= 6211–4 |year= 1989 |pmid= 2762324 |doi=10.1073/pnas.86.16.6211  | pmc=297807  |display-authors=etal}}
*{{cite journal  | author=Ford MJ, Anton IA, Lane DP |title=Nuclear protein with sequence homology to translation initiation factor eIF-4A. |journal=Nature |volume=332 |issue= 6166 |pages= 736-8 |year= 1988 |pmid= 2451786 |doi= 10.1038/332736a0 }}
*{{cite journal  | vauthors=Buelt MK, Glidden BJ, Storm DR |title=Regulation of p68 RNA helicase by calmodulin and protein kinase C |journal=J. Biol. Chem. |volume=269 |issue= 47 |pages= 29367–70 |year= 1994 |pmid= 7525583 |doi=  }}
*{{cite journal  | author=Iggo R, Gough A, Xu W, ''et al.'' |title=Chromosome mapping of the human gene encoding the 68-kDa nuclear antigen (p68) by using the polymerase chain reaction. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=86 |issue= 16 |pages= 6211-4 |year= 1989 |pmid= 2762324 |doi= }}
*{{cite journal  | vauthors=Brody LC, Abel KJ, Castilla LH |title=Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17 |journal=Genomics |volume=25 |issue= 1 |pages= 238–47 |year= 1995 |pmid= 7774924 |doi=10.1016/0888-7543(95)80131-5 |display-authors=etal}}
*{{cite journal  | author=Buelt MK, Glidden BJ, Storm DR |title=Regulation of p68 RNA helicase by calmodulin and protein kinase C. |journal=J. Biol. Chem. |volume=269 |issue= 47 |pages= 29367-70 |year= 1994 |pmid= 7525583 |doi=  }}
*{{cite journal  | vauthors=Endoh H, Maruyama K, Masuhiro Y |title=Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5363–72 |year= 1999 |pmid= 10409727 |doi=  | pmc=84379  |display-authors=etal}}
*{{cite journal  | author=Brody LC, Abel KJ, Castilla LH, ''et al.'' |title=Construction of a transcription map surrounding the BRCA1 locus of human chromosome 17. |journal=Genomics |volume=25 |issue= 1 |pages= 238-47 |year= 1995 |pmid= 7774924 |doi=  }}
*{{cite journal  | vauthors=Rössler OG, Hloch P, Schütz N |title=Structure and expression of the human p68 RNA helicase gene |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 932–9 |year= 2000 |pmid= 10648785 |doi=10.1093/nar/28.4.932 | pmc=102575  |display-authors=etal}}
*{{cite journal  | author=Endoh H, Maruyama K, Masuhiro Y, ''et al.'' |title=Purification and identification of p68 RNA helicase acting as a transcriptional coactivator specific for the activation function 1 of human estrogen receptor alpha. |journal=Mol. Cell. Biol. |volume=19 |issue= 8 |pages= 5363-72 |year= 1999 |pmid= 10409727 |doi=  }}
*{{cite journal  | vauthors=Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV |title=The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 272–80 |year= 2000 |pmid= 10837141 |doi= 10.1006/excr.2000.4886 }}
*{{cite journal  | author=Rössler OG, Hloch P, Schütz N, ''et al.'' |title=Structure and expression of the human p68 RNA helicase gene. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 932-9 |year= 2000 |pmid= 10648785 |doi=  }}
*{{cite journal  | vauthors=Watanabe M, Yanagisawa J, Kitagawa H |title=A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA |journal=EMBO J. |volume=20 |issue= 6 |pages= 1341–52 |year= 2001 |pmid= 11250900 |doi= 10.1093/emboj/20.6.1341 | pmc=145523 |display-authors=etal}}
*{{cite journal  | author=Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV |title=The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase. |journal=Exp. Cell Res. |volume=257 |issue= 2 |pages= 272-80 |year= 2000 |pmid= 10837141 |doi= 10.1006/excr.2000.4886 }}
*{{cite journal  | vauthors=Akileswaran L, Taraska JW, Sayer JA |title=A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17448–54 |year= 2001 |pmid= 11279182 |doi= 10.1074/jbc.M101171200 |display-authors=etal}}
*{{cite journal  | author=Watanabe M, Yanagisawa J, Kitagawa H, ''et al.'' |title=A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. |journal=EMBO J. |volume=20 |issue= 6 |pages= 1341-52 |year= 2001 |pmid= 11250900 |doi= 10.1093/emboj/20.6.1341 }}
*{{cite journal  | vauthors=Andersen JS, Lyon CE, Fox AH |title=Directed proteomic analysis of the human nucleolus |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1–11 |year= 2002 |pmid= 11790298 |doi=10.1016/S0960-9822(01)00650-9 |display-authors=etal}}
*{{cite journal  | author=Akileswaran L, Taraska JW, Sayer JA, ''et al.'' |title=A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17448-54 |year= 2001 |pmid= 11279182 |doi= 10.1074/jbc. M101171200 }}
*{{cite journal  | vauthors=Jurica MS, Licklider LJ, Gygi SR |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=10.1017/S1355838202021088 | pmc=1370266  |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lyon CE, Fox AH, ''et al.'' |title=Directed proteomic analysis of the human nucleolus. |journal=Curr. Biol. |volume=12 |issue= 1 |pages= 1-11 |year= 2002 |pmid= 11790298 |doi=  }}
*{{cite journal  | author=Liu ZR |title=p68 RNA Helicase Is an Essential Human Splicing Factor That Acts at the U1 snRNA-5′ Splice Site Duplex |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5443–50 |year= 2002 |pmid= 12101238 |doi=10.1128/MCB.22.15.5443-5450.2002  | pmc=133941  }}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Liu ZR |title=p68 RNA helicase is an essential human splicing factor that acts at the U1 snRNA-5' splice site duplex. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5443-50 |year= 2002 |pmid= 12101238 |doi= }}
*{{cite journal  | vauthors=Rossow KL, Janknecht R |title=Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300 |journal=Oncogene |volume=22 |issue= 1 |pages= 151–6 |year= 2003 |pmid= 12527917 |doi= 10.1038/sj.onc.1206067 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Guil S, Gattoni R, Carrascal M |title=Roles of hnRNP A1, SR Proteins, and p68 Helicase in c-H-ras Alternative Splicing Regulation |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2927–41 |year= 2003 |pmid= 12665590 |doi=10.1128/MCB.23.8.2927-2941.2003  | pmc=152554 |display-authors=etal}}
*{{cite journal  | author=Rossow KL, Janknecht R |title=Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300. |journal=Oncogene |volume=22 |issue= 1 |pages= 151-6 |year= 2003 |pmid= 12527917 |doi= 10.1038/sj.onc.1206067 }}
*{{cite journal  | vauthors=Fujita T, Kobayashi Y, Wada O |title=Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26704–14 |year= 2003 |pmid= 12738788 |doi= 10.1074/jbc.M301031200 |display-authors=etal}}
*{{cite journal  | author=Ogilvie VC, Wilson BJ, Nicol SM, ''et al.'' |title=The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells. |journal=Nucleic Acids Res. |volume=31 |issue= 5 |pages= 1470-80 |year= 2003 |pmid= 12595555 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Guil S, Gattoni R, Carrascal M, ''et al.'' |title=Roles of hnRNP A1, SR proteins, and p68 helicase in c-H-ras alternative splicing regulation. |journal=Mol. Cell. Biol. |volume=23 |issue= 8 |pages= 2927-41 |year= 2003 |pmid= 12665590 |doi= }}
*{{cite journal  | author=Fujita T, Kobayashi Y, Wada O, ''et al.'' |title=Full activation of estrogen receptor alpha activation function-1 induces proliferation of breast cancer cells. |journal=J. Biol. Chem. |volume=278 |issue= 29 |pages= 26704-14 |year= 2003 |pmid= 12738788 |doi= 10.1074/jbc. M301031200 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 3.6.4]]

Latest revision as of 18:20, 30 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.[1]

Function

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is an RNA-dependent ATPase, and also a proliferation-associated nuclear antigen, specifically reacting with the simian virus 40 tumor antigen. This gene consists of 13 exons, and alternatively spliced transcripts containing several intron sequences have been detected, but no isoforms encoded by these transcripts have been identified.[1]

Interactions

DDX5 has been shown to interact with:

References

  1. ↑ 1.0 1.1 "Entrez Gene: DDX5 DEAD (Asp-Glu-Ala-Asp) box polypeptide 5".
  2. ↑ Akileswaran L, Taraska JW, Sayer JA, Gettemy JM, Coghlan VM (May 2001). "A-kinase-anchoring protein AKAP95 is targeted to the nuclear matrix and associates with p68 RNA helicase". J. Biol. Chem. 276 (20): 17448–54. doi:10.1074/jbc.M101171200. PMID 11279182.
  3. ↑ Ogilvie VC, Wilson BJ, Nicol SM, Morrice NA, Saunders LR, Barber GN, Fuller-Pace FV (March 2003). "The highly related DEAD box RNA helicases p68 and p72 exist as heterodimers in cells". Nucleic Acids Res. 31 (5): 1470–80. doi:10.1093/nar/gkg236. PMC 149829. PMID 12595555.
  4. ↑ Wilson BJ, Giguère V (2007). "Identification of novel pathway partners of p68 and p72 RNA helicases through Oncomine meta-analysis". BMC Genomics. 8: 419. doi:10.1186/1471-2164-8-419. PMC 3225811. PMID 18005418.
  5. ↑ Endoh H, Maruyama K, Masuhiro Y, Kobayashi Y, Goto M, Tai H, Yanagisawa J, Metzger D, Hashimoto S, Kato S (August 1999). "Purification and Identification of p68 RNA Helicase Acting as a Transcriptional Coactivator Specific for the Activation Function 1 of Human Estrogen Receptor α". Mol. Cell. Biol. 19 (8): 5363–72. PMC 84379. PMID 10409727.
  6. ↑ Rossow KL, Janknecht R (January 2003). "Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300". Oncogene. 22 (1): 151–6. doi:10.1038/sj.onc.1206067. PMID 12527917.
  7. ↑ Nicol SM, Causevic M, Prescott AR, Fuller-Pace FV (June 2000). "The nuclear DEAD box RNA helicase p68 interacts with the nucleolar protein fibrillarin and colocalizes specifically in nascent nucleoli during telophase". Exp. Cell Res. 257 (2): 272–80. doi:10.1006/excr.2000.4886. PMID 10837141.
  8. ↑ Wilson BJ, Bates GJ, Nicol SM, Gregory DJ, Perkins ND, Fuller-Pace FV (August 2004). "The p68 and p72 DEAD box RNA helicases interact with HDAC1 and repress transcription in a promoter-specific manner". BMC Mol. Biol. 5: 11. doi:10.1186/1471-2199-5-11. PMC 514542. PMID 15298701.
  9. ↑ 9.0 9.1 9.2 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (March 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor α coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  10. ↑ Bates GJ, Nicol SM, Wilson BJ, Jacobs AM, Bourdon JC, Wardrop J, Gregory DJ, Lane DP, Perkins ND, Fuller-Pace FV (February 2005). "The DEAD box protein p68: a novel transcriptional coactivator of the p53 tumour suppressor". EMBO J. 24 (3): 543–53. doi:10.1038/sj.emboj.7600550. PMC 548656. PMID 15660129.
  11. ↑ Yao H, Brick K, Evrard Y, Xiao T, Camerini-Otero RD, Felsenfeld G (2010). "Mediation of CTCF transcriptional insulation by DEAD-box RNA-binding protein p68 and steroid receptor RNA activator SRA". Genes Dev. 24 (22): 2543–2555. doi:10.1101/gad.1967810. PMC 2975930. PMID 20966046.

Further reading

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