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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Mitogen-activated protein kinase kinase kinase 14''' also known as '''NF-kappa-B-inducing kinase''' (NIK) is an [[enzyme]] that in humans is encoded by the ''MAP3K14'' [[gene]].<ref name="pmid9020361">{{cite journal | vauthors = Malinin NL, Boldin MP, Kovalenko AV, Wallach D | title = MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1 | journal = Nature | volume = 385 | issue = 6616 | pages = 540–4 | date = March 1997 | pmid = 9020361 | pmc = | doi = 10.1038/385540a0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Mitogen-activated protein kinase kinase kinase 14
| HGNCid = 6853
| Symbol = MAP3K14
| AltSymbols =; FTDCR1B; HS; HSNIK; NIK
| OMIM = 604655
| ECnumber = 
| Homologene = 2940
| MGIid = 1858204
| GeneAtlas_image1 = PBB_GE_MAP3K14_205192_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004672 |text = protein kinase activity}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9020
    | Hs_Ensembl = ENSG00000006062
    | Hs_RefseqProtein = NP_003945
    | Hs_RefseqmRNA = NM_003954
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 40696278
    | Hs_GenLoc_end = 40750148
    | Hs_Uniprot = Q99558
    | Mm_EntrezGene = 53859
    | Mm_Ensembl = ENSMUSG00000020941
    | Mm_RefseqmRNA = NM_016896
    | Mm_RefseqProtein = NP_058592
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 103035854
    | Mm_GenLoc_end = 103083835
    | Mm_Uniprot = Q544K4
  }}
}}
'''Mitogen-activated protein kinase kinase kinase 14''', also known as '''MAP3K14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a [[serine/threonine-specific protein kinase|serine/threonine protein-kinase]]. This kinase binds to [[TRAF3]] and stimulates [[NF-κB]] activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor ([[tumor necrosis factors|TNF]]/[[Nerve growth factor|NGF]]) family and to the [[interleukin 1 receptor, type I|interleukin-1 type-I receptor]].<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes mitogen-activated protein kinase kinase kinase 14, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-kappaB activity. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-kappaB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.<ref name="entrez">{{cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
MAP3K14 has been shown to [[Protein-protein interaction|interact]] with:
* [[CHUK]],<ref name = pmid11278268/><ref name = pmid9244310>{{cite journal | vauthors = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | date = July 1997 | pmid = 9244310 | doi =  10.1016/S0092-8674(00)80344-X}}</ref><ref name = pmid10887201>{{cite journal | vauthors = Xiao G, Sun SC | title = Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21081–5 | date = July 2000 | pmid = 10887201 | doi = 10.1074/jbc.M002552200 }}</ref><ref name = pmid10094049>{{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | date = March 1999 | pmid = 10094049 | doi = 10.1038/18465 }}</ref>
* [[IKK2]],<ref name = pmid11278268/><ref name = pmid9346485>{{cite journal | vauthors = Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV | title = IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK | journal = Science | volume = 278 | issue = 5339 | pages = 866–9 | date = October 1997 | pmid = 9346485 | doi =  10.1126/science.278.5339.866}}</ref>  and
* [[TRAF2]].<ref name = pmid9020361 /><ref name = pmid11278268>{{cite journal | vauthors = Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E | title = Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40 | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 14602–6 | date = May 2001 | pmid = 11278268 | doi = 10.1074/jbc.C100103200 }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | year = 1997 | pmid = 9244310 | doi = 10.1016/S0092-8674(00)80344-X }}
| citations =
* {{cite journal | vauthors = Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M | title = Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 18 | pages = 9792–6 | year = 1997 | pmid = 9275204 | pmc = 23270 | doi = 10.1073/pnas.94.18.9792 }}
*{{cite journal | author=Malinin NL, Boldin MP, Kovalenko AV, Wallach D |title=MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1. |journal=Nature |volume=385 |issue= 6616 |pages= 540-4 |year= 1997 |pmid= 9020361 |doi= 10.1038/385540a0 }}
* {{cite journal | vauthors = Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV | title = IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK | journal = Science | volume = 278 | issue = 5339 | pages = 866–9 | year = 1997 | pmid = 9346485 | doi = 10.1126/science.278.5339.866 }}
*{{cite journal | author=Régnier CH, Song HY, Gao X, ''et al.'' |title=Identification and characterization of an IkappaB kinase. |journal=Cell |volume=90 |issue= 2 |pages= 373-83 |year= 1997 |pmid= 9244310 |doi= }}
* {{cite journal | vauthors = Ling L, Cao Z, Goeddel DV | title = NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 7 | pages = 3792–7 | year = 1998 | pmid = 9520446 | pmc = 19916 | doi = 10.1073/pnas.95.7.3792 }}
*{{cite journal  | author=Song HY, Régnier CH, Kirschning CJ, ''et al.'' |title=Tumor necrosis factor (TNF)-mediated kinase cascades: bifurcation of nuclear factor-kappaB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 18 |pages= 9792-6 |year= 1997 |pmid= 9275204 |doi= }}
* {{cite journal | vauthors = Lee FS, Peters RT, Dang LC, Maniatis T | title = MEKK1 activates both IκB kinase α and IκB kinase β | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 16 | pages = 9319–24 | year = 1998 | pmid = 9689078 | pmc = 21336 | doi = 10.1073/pnas.95.16.9319 }}
*{{cite journal | author=Woronicz JD, Gao X, Cao Z, ''et al.'' |title=IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK. |journal=Science |volume=278 |issue= 5339 |pages= 866-9 |year= 1997 |pmid= 9346485 |doi= }}
* {{cite journal | vauthors = Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC | title = Molecular Determinants of NF-κB-Inducing Kinase Action | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5899–907 | year = 1998 | pmid = 9742107 | pmc = 109176 | doi =  10.1128/mcb.18.10.5899}}
*{{cite journal | author=Ling L, Cao Z, Goeddel DV |title=NF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3792-7 |year= 1998 |pmid= 9520446 |doi= }}
* {{cite journal | vauthors = Cohen L, Henzel WJ, Baeuerle PA | title = IKAP is a scaffold protein of the IkappaB kinase complex | journal = Nature | volume = 395 | issue = 6699 | pages = 292–6 | year = 1998 | pmid = 9751059 | doi = 10.1038/26254 }}
*{{cite journal | author=Lee FS, Peters RT, Dang LC, Maniatis T |title=MEKK1 activates both IkappaB kinase alpha and IkappaB kinase beta. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 16 |pages= 9319-24 |year= 1998 |pmid= 9689078 |doi=  }}
* {{cite journal | vauthors = Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ | title = The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17 | journal = Hum. Genet. | volume = 103 | issue = 3 | pages = 340–5 | year = 1998 | pmid = 9799091 | doi = 10.1007/s004390050827 }}
*{{cite journal | author=Lin X, Mu Y, Cunningham ET, ''et al.'' |title=Molecular determinants of NF-kappaB-inducing kinase action. |journal=Mol. Cell. Biol. |volume=18 |issue= 10 |pages= 5899-907 |year= 1998 |pmid= 9742107 |doi= }}
* {{cite journal | vauthors = Nemoto S, DiDonato JA, Lin A | title = Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase | journal = Mol. Cell. Biol. | volume = 18 | issue = 12 | pages = 7336–43 | year = 1998 | pmid = 9819420 | pmc = 109315 | doi =  10.1128/mcb.18.12.7336}}
*{{cite journal | author=Cohen L, Henzel WJ, Baeuerle PA |title=IKAP is a scaffold protein of the IkappaB kinase complex. |journal=Nature |volume=395 |issue= 6699 |pages= 292-6 |year= 1998 |pmid= 9751059 |doi= 10.1038/26254 }}
* {{cite journal | vauthors = Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS | title = Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 3 | pages = 1042–7 | year = 1999 | pmid = 9927690 | pmc = 15347 | doi = 10.1073/pnas.96.3.1042 }}
*{{cite journal | author=Aronsson FC, Magnusson P, Andersson B, ''et al.'' |title=The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17. |journal=Hum. Genet. |volume=103 |issue= 3 |pages= 340-5 |year= 1998 |pmid= 9799091 |doi=  }}
* {{cite journal | vauthors = Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J | title = Activation of IκB Kinase β by Protein Kinase C Isoforms | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2180–8 | year = 1999 | pmid = 10022904 | pmc = 84010 | doi =  }}
*{{cite journal | author=Nemoto S, DiDonato JA, Lin A |title=Coordinate regulation of IkappaB kinases by mitogen-activated protein kinase kinase kinase 1 and NF-kappaB-inducing kinase. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7336-43 |year= 1998 |pmid= 9819420 |doi= }}
* {{cite journal | vauthors = Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC | title = The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases | journal = Immunity | volume = 10 | issue = 2 | pages = 271–80 | year = 1999 | pmid = 10072079 | doi = 10.1016/S1074-7613(00)80027-8 }}
*{{cite journal | author=Li Y, Kang J, Friedman J, ''et al.'' |title=Identification of a cell protein (FIP-3) as a modulator of NF-kappaB activity and as a target of an adenovirus inhibitor of tumor necrosis factor alpha-induced apoptosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 3 |pages= 1042-7 |year= 1999 |pmid= 9927690 |doi=  }}
* {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | year = 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
*{{cite journal | author=Lallena MJ, Diaz-Meco MT, Bren G, ''et al.'' |title=Activation of IkappaB kinase beta by protein kinase C isoforms. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 2180-8 |year= 1999 |pmid= 10022904 |doi= }}
* {{cite journal | vauthors = Delhase M, Hayakawa M, Chen Y, Karin M | title = Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation | journal = Science | volume = 284 | issue = 5412 | pages = 309–13 | year = 1999 | pmid = 10195894 | doi = 10.1126/science.284.5412.309 }}
*{{cite journal | author=Lin X, Cunningham ET, Mu Y, ''et al.'' |title=The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. |journal=Immunity |volume=10 |issue= 2 |pages= 271-80 |year= 1999 |pmid= 10072079 |doi= }}
* {{cite journal | vauthors = Hu WH, Johnson H, Shu HB | title = Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 30603–10 | year = 1999 | pmid = 10521444 | doi = 10.1074/jbc.274.43.30603 }}
*{{cite journal | author=Ninomiya-Tsuji J, Kishimoto K, Hiyama A, ''et al.'' |title=The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. |journal=Nature |volume=398 |issue= 6724 |pages= 252-6 |year= 1999 |pmid= 10094049 |doi= 10.1038/18465 }}
* {{cite journal | vauthors = Yamamoto Y, Yin MJ, Gaynor RB | title = IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3655–66 | year = 2000 | pmid = 10779355 | pmc = 85658 | doi = 10.1128/MCB.20.10.3655-3666.2000 }}
*{{cite journal | author=Delhase M, Hayakawa M, Chen Y, Karin M |title=Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation. |journal=Science |volume=284 |issue= 5412 |pages= 309-13 |year= 1999 |pmid= 10195894 |doi= }}
* {{cite journal | vauthors = Xiao G, Sun SC | title = Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21081–5 | year = 2000 | pmid = 10887201 | doi = 10.1074/jbc.M002552200 }}
*{{cite journal | author=Hu WH, Johnson H, Shu HB |title=Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30603-10 |year= 1999 |pmid= 10521444 |doi= }}
* {{cite journal | vauthors = Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L | title = Activation of the NF-kappaB pathway by caspase 8 and its homologs | journal = Oncogene | volume = 19 | issue = 39 | pages = 4451–60 | year = 2000 | pmid = 11002417 | doi = 10.1038/sj.onc.1203812 }}
*{{cite journal  | author=Yamamoto Y, Yin MJ, Gaynor RB |title=IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity. |journal=Mol. Cell. Biol. |volume=20 |issue= 10 |pages= 3655-66 |year= 2000 |pmid= 10779355 |doi=  }}
* {{cite journal | vauthors = Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM | title = The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A | journal = J. Biol. Chem. | volume = 276 | issue = 4 | pages = 2668–77 | year = 2001 | pmid = 11035039 | doi = 10.1074/jbc.M008356200 }}
*{{cite journal | author=Xiao G, Sun SC |title=Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain. |journal=J. Biol. Chem. |volume=275 |issue= 28 |pages= 21081-5 |year= 2000 |pmid= 10887201 |doi= 10.1074/jbc.M002552200 }}
*{{cite journal | author=Chaudhary PM, Eby MT, Jasmin A, ''et al.'' |title=Activation of the NF-kappaB pathway by caspase 8 and its homologs. |journal=Oncogene |volume=19 |issue= 39 |pages= 4451-60 |year= 2000 |pmid= 11002417 |doi= 10.1038/sj.onc.1203812 }}
*{{cite journal  | author=Kumar A, Eby MT, Sinha S, ''et al.'' |title=The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A. |journal=J. Biol. Chem. |volume=276 |issue= 4 |pages= 2668-77 |year= 2001 |pmid= 11035039 |doi= 10.1074/jbc.M008356200 }}
}}
{{refend}}
{{refend}}


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Revision as of 06:05, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.[1][2]

Function

This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF3 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.[2]

Interactions

MAP3K14 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Malinin NL, Boldin MP, Kovalenko AV, Wallach D (March 1997). "MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1". Nature. 385 (6616): 540–4. doi:10.1038/385540a0. PMID 9020361.
  2. ↑ 2.0 2.1 "Entrez Gene: MAP3K14 mitogen-activated protein kinase kinase kinase 14".
  3. ↑ 3.0 3.1 3.2 Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E (May 2001). "Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40". J. Biol. Chem. 276 (18): 14602–6. doi:10.1074/jbc.C100103200. PMID 11278268.
  4. ↑ Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M (July 1997). "Identification and characterization of an IkappaB kinase". Cell. 90 (2): 373–83. doi:10.1016/S0092-8674(00)80344-X. PMID 9244310.
  5. ↑ Xiao G, Sun SC (July 2000). "Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain". J. Biol. Chem. 275 (28): 21081–5. doi:10.1074/jbc.M002552200. PMID 10887201.
  6. ↑ Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K (March 1999). "The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway". Nature. 398 (6724): 252–6. doi:10.1038/18465. PMID 10094049.
  7. ↑ Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV (October 1997). "IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK". Science. 278 (5339): 866–9. doi:10.1126/science.278.5339.866. PMID 9346485.

Further reading


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