MYH2: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Myosin-2''' is a [[protein]] that in humans is encoded by the ''MYH2'' [[gene]].<ref name="pmid7545970">{{cite journal |vauthors=Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S | title = Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle | journal = Am J Physiol | volume = 267 | issue = 6 Pt 1 | pages = C1723–8 |date=Jan 1995 | pmid = 7545970 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4620| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Myosin, heavy chain 2, skeletal muscle, adult
| HGNCid = 7572
| Symbol = MYH2
| AltSymbols =; MYH2A; MYHSA2; MYHas8; MyHC-2A; MyHC-IIa
| OMIM = 160740
| ECnumber = 
| Homologene = 75068
| MGIid = 1339710
| GeneAtlas_image1 = PBB_GE_MYH2_204631_at_tn.png
| Function = {{GNF_GO|id=GO:0000146 |text = microfilament motor activity}} {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0005859 |text = muscle myosin complex}} {{GNF_GO|id=GO:0005863 |text = striated muscle thick filament}} {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0006941 |text = striated muscle contraction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4620
    | Hs_Ensembl = ENSG00000125414
    | Hs_RefseqProtein = NP_060004
    | Hs_RefseqmRNA = NM_017534
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 10365198
    | Hs_GenLoc_end = 10393704
    | Hs_Uniprot = Q9UKX2
    | Mm_EntrezGene = 17882
    | Mm_Ensembl = ENSMUSG00000033196
    | Mm_RefseqmRNA = NM_001039545
    | Mm_RefseqProtein = NP_001034634
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 66987261
    | Mm_GenLoc_end = 67013709
    | Mm_Uniprot =   
  }}
}}
'''Myosin, heavy chain 2, skeletal muscle, adult''', also known as '''MYH2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4620| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Schwartz CE, McNally E, Leinwand L, Skolnick MH |title=A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13. |journal=Cytogenet. Cell Genet. |volume=43 |issue= 1-2 |pages= 117-20 |year= 1987 |pmid= 2877813 |doi=  }}
*{{cite journal  |vauthors=Schwartz CE, McNally E, Leinwand L, Skolnick MH |title=A polymorphic human myosin heavy chain locus is linked to an anonymous single copy locus (D17S1) at 17p13. |journal=Cytogenet. Cell Genet. |volume=43 |issue= 1–2 |pages= 117–20 |year= 1987 |pmid= 2877813 |doi=10.1159/000132307 }}
*{{cite journal | author=Smerdu V, Karsch-Mizrachi I, Campione M, ''et al.'' |title=Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle. |journal=Am. J. Physiol. |volume=267 |issue= 6 Pt 1 |pages= C1723-8 |year= 1995 |pmid= 7545970 |doi=  }}
*{{cite journal   |vauthors=Ennion S, Sant'ana Pereira J, Sargeant AJ, etal |title=Characterization of human skeletal muscle fibres according to the myosin heavy chains they express |journal=J. Muscle Res. Cell. Motil. |volume=16 |issue= 1 |pages= 35–43 |year= 1995 |pmid= 7751403 |doi=10.1007/BF00125308 }}
*{{cite journal | author=Ennion S, Sant'ana Pereira J, Sargeant AJ, ''et al.'' |title=Characterization of human skeletal muscle fibres according to the myosin heavy chains they express. |journal=J. Muscle Res. Cell. Motil. |volume=16 |issue= 1 |pages= 35-43 |year= 1995 |pmid= 7751403 |doi=  }}
*{{cite journal   |vauthors=Hisatome I, Morisaki T, Kamma H, etal |title=Control of AMP deaminase 1 binding to myosin heavy chain |journal=Am. J. Physiol. |volume=275 |issue= 3 Pt 1 |pages= C870–81 |year= 1998 |pmid= 9730972 |doi=  }}
*{{cite journal | author=Hisatome I, Morisaki T, Kamma H, ''et al.'' |title=Control of AMP deaminase 1 binding to myosin heavy chain. |journal=Am. J. Physiol. |volume=275 |issue= 3 Pt 1 |pages= C870-81 |year= 1998 |pmid= 9730972 |doi=  }}
*{{cite journal   |vauthors=Weiss A, McDonough D, Wertman B, etal |title=Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2958–63 |year= 1999 |pmid= 10077619 |doi=10.1073/pnas.96.6.2958  | pmc=15877 }}
*{{cite journal  | author=Weiss A, McDonough D, Wertman B, ''et al.'' |title=Organization of human and mouse skeletal myosin heavy chain gene clusters is highly conserved. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2958-63 |year= 1999 |pmid= 10077619 |doi= }}
*{{cite journal  |vauthors=Weiss A, Schiaffino S, Leinwand LA |title=Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity |journal=J. Mol. Biol. |volume=290 |issue= 1 |pages= 61–75 |year= 1999 |pmid= 10388558 |doi= 10.1006/jmbi.1999.2865 }}
*{{cite journal | author=Weiss A, Schiaffino S, Leinwand LA |title=Comparative sequence analysis of the complete human sarcomeric myosin heavy chain family: implications for functional diversity. |journal=J. Mol. Biol. |volume=290 |issue= 1 |pages= 61-75 |year= 1999 |pmid= 10388558 |doi= 10.1006/jmbi.1999.2865 }}
*{{cite journal   |vauthors=Onuoha GN, Alpar EK, Laprade M, etal |title=Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 180–4 |year= 1999 |pmid= 10579056 |doi= }}
*{{cite journal | author=Onuoha GN, Alpar EK, Laprade M, ''et al.'' |title=Effects of bone fracture and surgery on plasma myosin heavy chain fragments of skeletal muscle. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 180-4 |year= 1999 |pmid= 10579056 |doi= }}
*{{cite journal   |vauthors=Martinsson T, Oldfors A, Darin N, etal |title=Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14614–9 |year= 2001 |pmid= 11114175 |doi= 10.1073/pnas.250289597  | pmc=18967 }}
*{{cite journal | author=Martinsson T, Oldfors A, Darin N, ''et al.'' |title=Autosomal dominant myopathy: missense mutation (Glu-706 --> Lys) in the myosin heavy chain IIa gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 26 |pages= 14614-9 |year= 2001 |pmid= 11114175 |doi= 10.1073/pnas.250289597 }}
*{{cite journal   |vauthors=Tajsharghi H, Thornell LE, Darin N, etal |title=Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age |journal=Neurology |volume=58 |issue= 5 |pages= 780–6 |year= 2002 |pmid= 11889243 |doi= 10.1212/wnl.58.5.780}}
*{{cite journal  | author=Tajsharghi H, Thornell LE, Darin N, ''et al.'' |title=Myosin heavy chain IIa gene mutation E706K is pathogenic and its expression increases with age. |journal=Neurology |volume=58 |issue= 5 |pages= 780-6 |year= 2002 |pmid= 11889243 |doi= }}
*{{cite journal  |vauthors=England K, Ashford D, Kidd D, Rumsby M |title=PKC epsilon is associated with myosin IIA and actin in fibroblasts |journal=Cell. Signal. |volume=14 |issue= 6 |pages= 529–36 |year= 2002 |pmid= 11897493 |doi=10.1016/S0898-6568(01)00277-7  }}
*{{cite journal  | author=England K, Ashford D, Kidd D, Rumsby M |title=PKC epsilon is associated with myosin IIA and actin in fibroblasts. |journal=Cell. Signal. |volume=14 |issue= 6 |pages= 529-36 |year= 2002 |pmid= 11897493 |doi= }}
*{{cite journal  |vauthors=Allen DL, Leinwand LA |title=Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45323–30 |year= 2003 |pmid= 12235157 |doi= 10.1074/jbc.M208302200 }}
*{{cite journal | author=Allen DL, Leinwand LA |title=Intracellular calcium and myosin isoform transitions. Calcineurin and calcium-calmodulin kinase pathways regulate preferential activation of the IIa myosin heavy chain promoter. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45323-30 |year= 2003 |pmid= 12235157 |doi= 10.1074/jbc.M208302200 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |vauthors=Kim EJ, Helfman DM |title=Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30063–73 |year= 2003 |pmid= 12756252 |doi= 10.1074/jbc.M304909200 }}
*{{cite journal | author=Kim EJ, Helfman DM |title=Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin. |journal=J. Biol. Chem. |volume=278 |issue= 32 |pages= 30063-73 |year= 2003 |pmid= 12756252 |doi= 10.1074/jbc.M304909200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Chung MC, Kawamoto S |title=IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 56042–52 |year= 2005 |pmid= 15496418 |doi= 10.1074/jbc.M404791200 }}
*{{cite journal | author=Chung MC, Kawamoto S |title=IRF-2 is involved in up-regulation of nonmuscle myosin heavy chain II-A gene expression during phorbol ester-induced promyelocytic HL-60 differentiation. |journal=J. Biol. Chem. |volume=279 |issue= 53 |pages= 56042-52 |year= 2005 |pmid= 15496418 |doi= 10.1074/jbc.M404791200 }}
*{{cite journal   |vauthors=Tajsharghi H, Darin N, Rekabdar E, etal |title=Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2) |journal=Eur. J. Hum. Genet. |volume=13 |issue= 5 |pages= 617–22 |year= 2005 |pmid= 15741996 |doi= 10.1038/sj.ejhg.5201375 }}
*{{cite journal | author=Tajsharghi H, Darin N, Rekabdar E, ''et al.'' |title=Mutations and sequence variation in the human myosin heavy chain IIa gene (MYH2). |journal=Eur. J. Hum. Genet. |volume=13 |issue= 5 |pages= 617-22 |year= 2005 |pmid= 15741996 |doi= 10.1038/sj.ejhg.5201375 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Li M, Lionikas A, Yu F, etal |title=Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys) |journal=Neuromuscul. Disord. |volume=16 |issue= 11 |pages= 782–91 |year= 2006 |pmid= 17005402 |doi= 10.1016/j.nmd.2006.07.023  | pmc=1693964 }}
*{{cite journal | author=Li M, Lionikas A, Yu F, ''et al.'' |title=Muscle cell and motor protein function in patients with a IIa myosin missense mutation (Glu-706 to Lys). |journal=Neuromuscul. Disord. |volume=16 |issue= 11 |pages= 782-91 |year= 2006 |pmid= 17005402 |doi= 10.1016/j.nmd.2006.07.023 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Cytoskeletal Proteins}}
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{{gene-17-stub}}

Latest revision as of 07:12, 4 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin-2 is a protein that in humans is encoded by the MYH2 gene.[1][2]


References

  1. ↑ Smerdu V, Karsch-Mizrachi I, Campione M, Leinwand L, Schiaffino S (Jan 1995). "Type IIx myosin heavy chain transcripts are expressed in type IIb fibers of human skeletal muscle". Am J Physiol. 267 (6 Pt 1): C1723–8. PMID 7545970.
  2. ↑ "Entrez Gene: MYH2 myosin, heavy chain 2, skeletal muscle, adult".

Further reading



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