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{{Infobox_gene}}
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'''Ubiquitin carboxyl-terminal hydrolase 6''' is an [[enzyme]] that in humans is encoded by the ''USP6'' [[gene]].<ref name="pmid12838346">{{cite journal | vauthors = Puente XS, Sanchez LM, Overall CM, Lopez-Otin C | title = Human and mouse proteases: a comparative genomic approach | journal = Nat Rev Genet | volume = 4 | issue = 7 | pages = 544–58 |date=Jul 2003 | pmid = 12838346 | pmc =  | doi = 10.1038/nrg1111 }}</ref><ref name="pmid1349106">{{cite journal  |vauthors=Hoogendijk JE, Hensels GW, Gabreels-Festen AA, Gabreels FJ, Janssen EA, de Jonghe P, Martin JJ, van Broeckhoven C, Valentijn LJ, Baas F, etal | title = De-novo mutation in hereditary motor and sensory neuropathy type I | journal = Lancet | volume = 339 | issue = 8801 | pages = 1081–2 |date=May 1992 | pmid = 1349106 | pmc =  | doi =10.1016/0140-6736(92)90668-S }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9098| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Ubiquitin specific peptidase 6 (Tre-2 oncogene)
| HGNCid = 12629
| Symbol = USP6
| AltSymbols =; TRE2; HRP1; TRE17; Tre-2
| OMIM = 604334
| ECnumber =
  | Homologene =
| MGIid = 
| GeneAtlas_image1 = PBB_GE_USP6_206405_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0004197 |text = cysteine-type endopeptidase activity}} {{GNF_GO|id=GO:0004221 |text = ubiquitin thiolesterase activity}} {{GNF_GO|id=GO:0008233 |text = peptidase activity}}
| Component = {{GNF_GO|id=GO:0005764 |text = lysosome}}
  | Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9098
    | Hs_Ensembl = ENSG00000129204
    | Hs_RefseqProtein = XP_001134439
    | Hs_RefseqmRNA = XM_001134439
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 4972411
    | Hs_GenLoc_end = 5019053
    | Hs_Uniprot = P35125
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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  }}
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'''Ubiquitin specific peptidase 6 (Tre-2 oncogene)''', also known as '''USP6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9098| accessdate = }}</ref>


[[Aneurysmal bone cyst]] can be associated with a ''[[TRE17]]''/'''''USP6''''' translocation.<ref name="pmid20418905">{{cite journal  |vauthors=Ye Y, Pringle LM, Lau AW, etal |title=TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NFκB |journal=Oncogene |volume=29 |issue=25 |pages=3619–29 |date=June 2010 |pmid=20418905 |pmc=2892027 |doi=10.1038/onc.2010.116 }}</ref>
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==References==
{{reflist}}


==References==
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators. |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337-52 |year= 1999 |pmid= 9827704 |doi=  }}
*{{cite journal  | vauthors=D'Andrea A, Pellman D |title=Deubiquitinating enzymes: a new class of biological regulators |journal=Crit. Rev. Biochem. Mol. Biol. |volume=33 |issue= 5 |pages= 337–52 |year= 1999 |pmid= 9827704 |doi=10.1080/10409239891204251 }}
*{{cite journal  | author=Puente XS, Sánchez LM, Overall CM, López-Otín C |title=Human and mouse proteases: a comparative genomic approach. |journal=Nat. Rev. Genet. |volume=4 |issue= 7 |pages= 544-58 |year= 2003 |pmid= 12838346 |doi= 10.1038/nrg1111 }}
*{{cite journal   |vauthors=Nakamura T, Hillova J, Mariage-Samson R, etal |title=A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells |journal=Oncogene |volume=7 |issue= 4 |pages= 733–41 |year= 1992 |pmid= 1565468 |doi=  }}
*{{cite journal  | author=Hoogendijk JE, Hensels GW, Gabreëls-Festen AA, ''et al.'' |title=De-novo mutation in hereditary motor and sensory neuropathy type I. |journal=Lancet |volume=339 |issue= 8801 |pages= 1081-2 |year= 1992 |pmid= 1349106 |doi= }}
*{{cite journal  | vauthors=Papa FR, Hochstrasser M |title=The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene |journal=Nature |volume=366 |issue= 6453 |pages= 313–9 |year= 1993 |pmid= 8247125 |doi= 10.1038/366313a0 }}
*{{cite journal | author=Nakamura T, Hillova J, Mariage-Samson R, ''et al.'' |title=A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells. |journal=Oncogene |volume=7 |issue= 4 |pages= 733-41 |year= 1992 |pmid= 1565468 |doi=  }}
*{{cite journal  | vauthors=Onno M, Nakamura T, Hillova J, Hill M |title=Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes |journal=Gene |volume=131 |issue= 2 |pages= 209–15 |year= 1993 |pmid= 8406013 |doi=10.1016/0378-1119(93)90295-E }}
*{{cite journal  | author=Papa FR, Hochstrasser M |title=The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene. |journal=Nature |volume=366 |issue= 6453 |pages= 313-9 |year= 1993 |pmid= 8247125 |doi= 10.1038/366313a0 }}
*{{cite journal   |vauthors=Onno M, Nakamura T, Mariage-Samson R, etal |title=Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes |journal=DNA Cell Biol. |volume=12 |issue= 2 |pages= 107–18 |year= 1993 |pmid= 8471161 |doi=10.1089/dna.1993.12.107 }}
*{{cite journal  | author=Onno M, Nakamura T, Hillova J, Hill M |title=Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes. |journal=Gene |volume=131 |issue= 2 |pages= 209-15 |year= 1993 |pmid= 8406013 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Onno M, Nakamura T, Mariage-Samson R, ''et al.'' |title=Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes. |journal=DNA Cell Biol. |volume=12 |issue= 2 |pages= 107-18 |year= 1993 |pmid= 8471161 |doi=  }}
*{{cite journal  | vauthors=Paulding CA, Ruvolo M, Haber DA |title=The Tre2 (USP6) oncogene is a hominoid-specific gene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2507–11 |year= 2003 |pmid= 12604796 |doi= 10.1073/pnas.0437015100 | pmc=151371 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Masuda-Robens JM, Kutney SN, Qi H, Chou MM |title=The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2151–61 |year= 2003 |pmid= 12612085 |doi=10.1128/MCB.23.6.2151-2161.2003  | pmc=149457 }}
*{{cite journal  | author=Paulding CA, Ruvolo M, Haber DA |title=The Tre2 (USP6) oncogene is a hominoid-specific gene. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 5 |pages= 2507-11 |year= 2003 |pmid= 12604796 |doi= 10.1073/pnas.0437015100 }}
*{{cite journal   |vauthors=Bizimungu C, De Neve N, Burny A, etal |title=Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 2 |pages= 498–504 |year= 2003 |pmid= 14521938 |doi=10.1016/j.bbrc.2003.09.051 }}
*{{cite journal  | author=Masuda-Robens JM, Kutney SN, Qi H, Chou MM |title=The TRE17 oncogene encodes a component of a novel effector pathway for Rho GTPases Cdc42 and Rac1 and stimulates actin remodeling. |journal=Mol. Cell. Biol. |volume=23 |issue= 6 |pages= 2151-61 |year= 2003 |pmid= 12612085 |doi=  }}
*{{cite journal   |vauthors=Oliveira AM, Hsi BL, Weremowicz S, etal |title=USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst |journal=Cancer Res. |volume=64 |issue= 6 |pages= 1920–3 |year= 2004 |pmid= 15026324 |doi=10.1158/0008-5472.CAN-03-2827 }}
*{{cite journal | author=Bizimungu C, De Neve N, Burny A, ''et al.'' |title=Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene. |journal=Biochem. Biophys. Res. Commun. |volume=310 |issue= 2 |pages= 498-504 |year= 2003 |pmid= 14521938 |doi=  }}
*{{cite journal   |vauthors=Oliveira AM, Perez-Atayde AR, Inwards CY, etal |title=USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts |journal=Am. J. Pathol. |volume=165 |issue= 5 |pages= 1773–80 |year= 2004 |pmid= 15509545 |doi=  10.1016/S0002-9440(10)63432-3 |pmc=3278819}}
*{{cite journal | author=Oliveira AM, Hsi BL, Weremowicz S, ''et al.'' |title=USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst. |journal=Cancer Res. |volume=64 |issue= 6 |pages= 1920-3 |year= 2004 |pmid= 15026324 |doi=  }}
*{{cite journal   |vauthors=Martinu L, Masuda-Robens JM, Robertson SE, etal |title=The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6 |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 9752–62 |year= 2004 |pmid= 15509780 |doi= 10.1128/MCB.24.22.9752-9762.2004 | pmc=525471 }}
*{{cite journal | author=Oliveira AM, Perez-Atayde AR, Inwards CY, ''et al.'' |title=USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. |journal=Am. J. Pathol. |volume=165 |issue= 5 |pages= 1773-80 |year= 2004 |pmid= 15509545 |doi=  }}
*{{cite journal   |vauthors=Oliveira AM, Perez-Atayde AR, Dal Cin P, etal |title=Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes |journal=Oncogene |volume=24 |issue= 21 |pages= 3419–26 |year= 2005 |pmid= 15735689 |doi= 10.1038/sj.onc.1208506 }}
*{{cite journal | author=Martinu L, Masuda-Robens JM, Robertson SE, ''et al.'' |title=The TBC (Tre-2/Bub2/Cdc16) domain protein TRE17 regulates plasma membrane-endosomal trafficking through activation of Arf6. |journal=Mol. Cell. Biol. |volume=24 |issue= 22 |pages= 9752-62 |year= 2004 |pmid= 15509780 |doi= 10.1128/MCB.24.22.9752-9762.2004 }}
*{{cite journal  | vauthors=Bizimungu C, Vandenbol M |title=At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 3 |pages= 883–90 |year= 2005 |pmid= 16099424 |doi= 10.1016/j.bbrc.2005.07.159 }}
*{{cite journal | author=Oliveira AM, Perez-Atayde AR, Dal Cin P, ''et al.'' |title=Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes. |journal=Oncogene |volume=24 |issue= 21 |pages= 3419-26 |year= 2005 |pmid= 15735689 |doi= 10.1038/sj.onc.1208506 }}
*{{cite journal   |vauthors=Shen C, Ye Y, Robertson SE, etal |title=Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6 |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 35967–73 |year= 2006 |pmid= 16127172 |doi= 10.1074/jbc.M505220200 }}
*{{cite journal  | author=Bizimungu C, Vandenbol M |title=At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity. |journal=Biochem. Biophys. Res. Commun. |volume=335 |issue= 3 |pages= 883-90 |year= 2005 |pmid= 16099424 |doi= 10.1016/j.bbrc.2005.07.159 }}
*{{cite journal  | vauthors=Dechamps C, Bach S, Portetelle D, Vandenbol M |title=The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton |journal=Biotechnol. Lett. |volume=28 |issue= 4 |pages= 223–31 |year= 2006 |pmid= 16555005 |doi= 10.1007/s10529-005-5523-2 }}
*{{cite journal | author=Shen C, Ye Y, Robertson SE, ''et al.'' |title=Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6. |journal=J. Biol. Chem. |volume=280 |issue= 43 |pages= 35967-73 |year= 2006 |pmid= 16127172 |doi= 10.1074/jbc.M505220200 }}
*{{cite journal  | author=Dechamps C, Bach S, Portetelle D, Vandenbol M |title=The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton. |journal=Biotechnol. Lett. |volume=28 |issue= 4 |pages= 223-31 |year= 2006 |pmid= 16555005 |doi= 10.1007/s10529-005-5523-2 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
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{{Posttranslational modification}}
 
 
{{gene-17-stub}}

Latest revision as of 10:05, 17 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin carboxyl-terminal hydrolase 6 is an enzyme that in humans is encoded by the USP6 gene.[1][2][3]

Aneurysmal bone cyst can be associated with a TRE17/USP6 translocation.[4]

References

  1. ↑ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346.
  2. ↑ Hoogendijk JE, Hensels GW, Gabreels-Festen AA, Gabreels FJ, Janssen EA, de Jonghe P, Martin JJ, van Broeckhoven C, Valentijn LJ, Baas F, et al. (May 1992). "De-novo mutation in hereditary motor and sensory neuropathy type I". Lancet. 339 (8801): 1081–2. doi:10.1016/0140-6736(92)90668-S. PMID 1349106.
  3. ↑ "Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene)".
  4. ↑ Ye Y, Pringle LM, Lau AW, et al. (June 2010). "TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NFκB". Oncogene. 29 (25): 3619–29. doi:10.1038/onc.2010.116. PMC 2892027. PMID 20418905.

Further reading



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