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{{Infobox_gene}}
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'''Zinc transporter ZIP6''' is a [[protein]] that in humans is encoded by the ''SLC39A6'' [[gene]].<ref name="pmid12659941">{{cite journal | vauthors = Taylor KM, Nicholson RI | title = The LZT proteins; the LIV-1 subfamily of zinc transporters | journal = Biochim Biophys Acta | volume = 1611 | issue = 1–2 | pages = 16–30 |date=Mar 2003 | pmid = 12659941 | pmc = | doi =10.1016/S0005-2736(03)00048-8 }}</ref><ref name="pmid12839489">{{cite journal | vauthors = Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI | title = Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters | journal = Biochem J | volume = 375 | issue = Pt 1 | pages = 51–9 |date=Sep 2003 | pmid = 12839489 | pmc = 1223660 | doi = 10.1042/BJ20030478 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25800| accessdate = }}</ref>
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| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 39 (zinc transporter), member 6
| HGNCid = 18607
| Symbol = SLC39A6
| AltSymbols =; LIV-1
| OMIM = 608731
| ECnumber = 
| Homologene = 8199
| MGIid = 2147279
| GeneAtlas_image1 = PBB_GE_SLC39A6_202088_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC39A6_202089_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046873 |text = metal ion transmembrane transporter activity}}
  | Component = {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006829 |text = zinc ion transport}} {{GNF_GO|id=GO:0030001 |text = metal ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 25800
    | Hs_Ensembl = ENSG00000141424
    | Hs_RefseqProtein = NP_036451
    | Hs_RefseqmRNA = NM_012319
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 18
    | Hs_GenLoc_start = 31943197
    | Hs_GenLoc_end = 31963203
    | Hs_Uniprot = Q13433
    | Mm_EntrezGene = 106957
    | Mm_Ensembl = ENSMUSG00000024270
    | Mm_RefseqmRNA = NM_139143
    | Mm_RefseqProtein = NP_631882
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 24722898
    | Mm_GenLoc_end = 24746785
    | Mm_Uniprot = Q8C145
  }}
}}
'''Solute carrier family 39 (zinc transporter), member 6''', also known as '''SLC39A6''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25800| accessdate = }}</ref>


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| section_title =  
| section_title =  
| summary_text = Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=25800| accessdate = }}</ref>
| summary_text = Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM]<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Taylor KM, Nicholson RI |title=The LZT proteins; the LIV-1 subfamily of zinc transporters. |journal=Biochim. Biophys. Acta |volume=1611 |issue= 1-2 |pages= 16-30 |year= 2003 |pmid= 12659941 |doi=  }}
*{{cite journal   |vauthors=Manning DL, Daly RJ, Lord PG, etal |title=Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line |journal=Mol. Cell. Endocrinol. |volume=59 |issue= 3 |pages= 205–12 |year= 1988 |pmid= 2903103 |doi=10.1016/0303-7207(88)90105-0 }}
*{{cite journal  | author=Manning DL, Daly RJ, Lord PG, ''et al.'' |title=Effects of oestrogen on the expression of a 4.4 kb mRNA in the ZR-75-1 human breast cancer cell line. |journal=Mol. Cell. Endocrinol. |volume=59 |issue= 3 |pages= 205-12 |year= 1988 |pmid= 2903103 |doi=  }}
*{{cite journal   |vauthors=Dressman MA, Walz TM, Lavedan C, etal |title=Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies |journal=Pharmacogenomics J. |volume=1 |issue= 2 |pages= 135–41 |year= 2002 |pmid= 11911440 |doi=  }}
*{{cite journal | author=Dressman MA, Walz TM, Lavedan C, ''et al.'' |title=Genes that co-cluster with estrogen receptor alpha in microarray analysis of breast biopsies. |journal=Pharmacogenomics J. |volume=1 |issue= 2 |pages= 135-41 |year= 2002 |pmid= 11911440 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Schaner ME, Ross DT, Ciaravino G, etal |title=Gene expression patterns in ovarian carcinomas |journal=Mol. Biol. Cell |volume=14 |issue= 11 |pages= 4376–86 |year= 2004 |pmid= 12960427 |doi= 10.1091/mbc.E03-05-0279 | pmc=266758 }}
*{{cite journal | author=Taylor KM, Morgan HE, Johnson A, ''et al.'' |title=Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. |journal=Biochem. J. |volume=375 |issue= Pt 1 |pages= 51-9 |year= 2003 |pmid= 12839489 |doi= 10.1042/BJ20030478 }}
*{{cite journal  | vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 | pmc=2286551 }}
*{{cite journal | author=Schaner ME, Ross DT, Ciaravino G, ''et al.'' |title=Gene expression patterns in ovarian carcinomas. |journal=Mol. Biol. Cell |volume=14 |issue= 11 |pages= 4376-86 |year= 2004 |pmid= 12960427 |doi= 10.1091/mbc.E03-05-0279 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
*{{cite journal   |vauthors=Kasper G, Weiser AA, Rump A, etal |title=Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients |journal=Int. J. Cancer |volume=117 |issue= 6 |pages= 961–73 |year= 2005 |pmid= 15986450 |doi= 10.1002/ijc.21235 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Zhao L, Chen W, Taylor KM, etal |title=LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway |journal=Biochem. Biophys. Res. Commun. |volume=363 |issue= 1 |pages= 82–8 |year= 2007 |pmid= 17825787 |doi= 10.1016/j.bbrc.2007.08.127 }}
*{{cite journal | author=Kasper G, Weiser AA, Rump A, ''et al.'' |title=Expression levels of the putative zinc transporter LIV-1 are associated with a better outcome of breast cancer patients. |journal=Int. J. Cancer |volume=117 |issue= 6 |pages= 961-73 |year= 2005 |pmid= 15986450 |doi= 10.1002/ijc.21235 }}
*{{cite journal | author=Zhao L, Chen W, Taylor KM, ''et al.'' |title=LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. |journal=Biochem. Biophys. Res. Commun. |volume=363 |issue= 1 |pages= 82-8 |year= 2007 |pmid= 17825787 |doi= 10.1016/j.bbrc.2007.08.127 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:33, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc transporter ZIP6 is a protein that in humans is encoded by the SLC39A6 gene.[1][2][3]

Zinc is an essential cofactor for hundreds of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. SLC39A6 belongs to a subfamily of proteins that show structural characteristics of zinc transporters (Taylor and Nicholson, 2003).[supplied by OMIM][3]

See also

References

  1. ↑ Taylor KM, Nicholson RI (Mar 2003). "The LZT proteins; the LIV-1 subfamily of zinc transporters". Biochim Biophys Acta. 1611 (1–2): 16–30. doi:10.1016/S0005-2736(03)00048-8. PMID 12659941.
  2. ↑ Taylor KM, Morgan HE, Johnson A, Hadley LJ, Nicholson RI (Sep 2003). "Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters". Biochem J. 375 (Pt 1): 51–9. doi:10.1042/BJ20030478. PMC 1223660. PMID 12839489.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC39A6 solute carrier family 39 (zinc transporter), member 6".

Further reading


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