GSK3A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Glycogen synthase kinase-3 alpha''' is an [[enzyme]] that in humans is encoded by the ''GSK3A'' [[gene]].<ref name="pmid9809441">{{cite journal | vauthors = Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH | title = Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes | journal = Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada | volume = 41 | issue = 5 | pages = 720–7 | date = Oct 1998 | pmid = 9809441 | pmc = | doi = 10.1139/gen-41-5-720 }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Glycogen synthase kinase 3-alpha {{EC number|2.7.1.37}} is a multifunctional protein serine [[kinase]], homologous to ''[[Drosophila melanogaster|Drosophila]]'' 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including [[glycogen synthase]] and various [[transcription factor]]s (e.g., [[c-Jun|JUN]]). It also plays a role in the [[Wnt signaling pathway|WNT]] and [[phosphoinositide 3-kinase]] (especially [[PIK3CG]]) signaling pathways.<ref name="pmid11749387">{{cite journal | vauthors = Ali A, Hoeflich KP, Woodgett JR | title = Glycogen synthase kinase-3: properties, functions, and regulation | journal = Chemical Reviews | volume = 101 | issue = 8 | pages = 2527–40 | date = Aug 2001 | pmid = 11749387 | doi = 10.1021/cr000110o }}</ref><ref>{{cite web | title = Entrez Gene: GSK3A glycogen synthase kinase 3 alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2931| accessdate = }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Glycogen synthase kinase 3 alpha
| HGNCid = 4616
| Symbol = GSK3A
| AltSymbols =; DKFZp686D0638
| OMIM = 606784
| ECnumber = 
| Homologene = 88581
| MGIid = 2152453
| GeneAtlas_image1 = PBB_GE_GSK3A_632_at_tn.png
| GeneAtlas_image2 = PBB_GE_GSK3A_202210_x_at_tn.png
<!-- The Following entry is a time stamp of the last bot update. It is typically hidden data -->
| DateOfBotUpdate = 06:50, 9 October 2007 (UTC)
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =  
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2931
    | Hs_Ensembl = ENSG00000105723
    | Hs_RefseqProtein = NP_063937
    | Hs_RefseqmRNA = NM_019884
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 47426186
    | Hs_GenLoc_end = 47438591
    | Hs_Uniprot = P49840
    | Mm_EntrezGene = 606496
    | Mm_Ensembl = ENSMUSG00000057177
    | Mm_RefseqmRNA = NM_001031667
    | Mm_RefseqProtein = NP_001026837
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 24937019
    | Mm_GenLoc_end = 24946611
    | Mm_Uniprot = 
  }}
}}
'''Glycogen synthase kinase 3 alpha''', also known as '''GSK3A''', is a human [[gene]].


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==Model organisms==
{{PBB_Summary
{| class="wikitable sortable collapsible collapsed" border="1" cellpadding="2" style="float: right;" |
| section_title =  
|+ ''Gsk3a'' knockout mouse phenotype
| summary_text = Glycogen synthase kinase 3-alpha (GSK3A; EC {2.7.1.37}) is a multifunctional protein serine [[kinase]], homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including [[glycogen synthase]] (see [[GYS1]], {138570}) and [[transcription factor]]s (e.g., [[c-Jun|JUN]], {165160}). It also plays a role in the [[Wnt signaling pathway|WNT]] ({164820}) and [[PI3K]] (see PIK3CG, {601232}) signaling pathways (see review by {1:Ali et al. (2001)}).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GSK3A glycogen synthase kinase 3 alpha| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2931| accessdate = }}</ref>
|-
}}
! Characteristic!! Phenotype


==References==
|-
{{reflist|2}}
| [[Homozygote]] viability || bgcolor="#488ED3"|Normal
==Further reading==
|-
{{refbegin | 2}}
| Homozygous Fertility || bgcolor="#488ED3"|Normal
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| citations =  
| Body weight || bgcolor="#488ED3"|Normal
*{{cite journal | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527-40 |year= 2002 |pmid= 11749387 |doi= }}
|-
}}
| [[Open_Field_(animal_test)|Anxiety]] || bgcolor="#488ED3"|Normal
{{refend}}
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| Neurological assessment || bgcolor="#488ED3"|Normal
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| Grip strength || bgcolor="#488ED3"|Normal
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| [[Hot_plate_test|Hot plate]] || bgcolor="#488ED3"|Normal
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| [[Dysmorphology]] || bgcolor="#488ED3"|Normal
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| [[Indirect calorimetry]] || bgcolor="#488ED3"|Normal
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| [[Glucose tolerance test]] || bgcolor="#488ED3"|Normal
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| [[Auditory brainstem response]] || bgcolor="#488ED3"|Normal
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| [[Dual-energy_X-ray_absorptiometry|DEXA]] || bgcolor="#488ED3"|Normal
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| [[Radiography]] || bgcolor="#488ED3"|Normal
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| Body temperature || bgcolor="#488ED3"|Normal
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| Eye morphology || bgcolor="#488ED3"|Normal
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| [[Clinical chemistry]] || bgcolor="#488ED3"|Normal
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| [[Haematology]] || bgcolor="#488ED3"|Normal
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| [[Peripheral blood lymphocyte]]s || bgcolor="#488ED3"|Normal
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| [[Micronucleus test]] || bgcolor="#488ED3"|Normal
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| Heart weight || bgcolor="#488ED3"|Normal
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| Skin Histopathology || bgcolor="#488ED3"|Normal
|-
| colspan=2; style="text-align: center;" | All tests and analysis from<ref name="mgp_reference">{{cite journal | doi = 10.1111/j.1755-3768.2010.4142.x | title = The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice | year = 2010 | author = Gerdin AK | journal = Acta Ophthalmologica | volume = 88 | pages = 925–7 }}</ref><ref>[http://www.sanger.ac.uk/mouseportal/ Mouse Resources Portal], Wellcome Trust Sanger Institute.</ref>
|}
[[Model organism]]s have been used in the study of GSK3A function. A conditional [[knockout mouse]] line, called ''Gsk3a<sup>tm1a(EUCOMM)Wtsi</sup>''<ref name="allele_ref">{{cite web |url=http://www.knockoutmouse.org/martsearch/search?query=Gsk3a |title=International Knockout Mouse Consortium}}</ref><ref name="mgi_allele_ref">{{cite web |url=http://www.informatics.jax.org/searchtool/Search.do?query=MGI:4434136 |title=Mouse Genome Informatics}}</ref> was generated as part of the [[International Knockout Mouse Consortium]] program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.<ref name="pmid21677750">{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}</ref><ref name="mouse_library">{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}</ref><ref name="mouse_for_all_reasons">{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}</ref>


{{protein-stub}}
Male and female animals underwent a standardized [[phenotypic screen]] to determine the effects of deletion.<ref name="mgp_reference" /><ref name="pmid21722353">{{cite journal | vauthors = van der Weyden L, White JK, Adams DJ, Logan DW | title = The mouse genetics toolkit: revealing function and mechanism | journal = Genome Biology | volume = 12 | issue = 6 | pages = 224 | year = 2011 | pmid = 21722353 | pmc = 3218837 | doi = 10.1186/gb-2011-12-6-224 }} </ref> Twenty one tests were carried out on [[mutant]] mice but no significant abnormalities were observed.<ref name="mgp_reference" />
{{WikiDoc Sources}}
 
== See also ==
* [[Glycogen synthase kinase 3]]
 
== References ==
{{reflist}}
 
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
{{gene-19-stub}}
 
[[Category:Protein kinases]]
[[Category:EC 2.7.11]]
[[Category:Genes mutated in mice]]

Latest revision as of 08:06, 1 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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Wikidata
View/Edit Human

Glycogen synthase kinase-3 alpha is an enzyme that in humans is encoded by the GSK3A gene.[1]

Glycogen synthase kinase 3-alpha EC 2.7.1.37 is a multifunctional protein serine kinase, homologous to Drosophila 'shaggy' (zeste-white3) and implicated in the control of several regulatory proteins including glycogen synthase and various transcription factors (e.g., JUN). It also plays a role in the WNT and phosphoinositide 3-kinase (especially PIK3CG) signaling pathways.[2][3]

Model organisms

Model organisms have been used in the study of GSK3A function. A conditional knockout mouse line, called Gsk3atm1a(EUCOMM)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.[8][9][10]

Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion.[4][11] Twenty one tests were carried out on mutant mice but no significant abnormalities were observed.[4]

See also

References

  1. ↑ Shaw PC, Davies AF, Lau KF, Garcia-Barcelo M, Waye MM, Lovestone S, Miller CC, Anderton BH (Oct 1998). "Isolation and chromosomal mapping of human glycogen synthase kinase-3 alpha and -3 beta encoding genes". Genome / National Research Council Canada = Génome / Conseil National De Recherches Canada. 41 (5): 720–7. doi:10.1139/gen-41-5-720. PMID 9809441.
  2. ↑ Ali A, Hoeflich KP, Woodgett JR (Aug 2001). "Glycogen synthase kinase-3: properties, functions, and regulation". Chemical Reviews. 101 (8): 2527–40. doi:10.1021/cr000110o. PMID 11749387.
  3. ↑ "Entrez Gene: GSK3A glycogen synthase kinase 3 alpha".
  4. ↑ 4.0 4.1 4.2 Gerdin AK (2010). "The Sanger Mouse Genetics Programme: High throughput characterisation of knockout mice". Acta Ophthalmologica. 88: 925–7. doi:10.1111/j.1755-3768.2010.4142.x.
  5. ↑ Mouse Resources Portal, Wellcome Trust Sanger Institute.
  6. ↑ "International Knockout Mouse Consortium".
  7. ↑ "Mouse Genome Informatics".
  8. ↑ Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A (Jun 2011). "A conditional knockout resource for the genome-wide study of mouse gene function". Nature. 474 (7351): 337–42. doi:10.1038/nature10163. PMC 3572410. PMID 21677750.
  9. ↑ Dolgin E (Jun 2011). "Mouse library set to be knockout". Nature. 474 (7351): 262–3. doi:10.1038/474262a. PMID 21677718.
  10. ↑ Collins FS, Rossant J, Wurst W (Jan 2007). "A mouse for all reasons". Cell. 128 (1): 9–13. doi:10.1016/j.cell.2006.12.018. PMID 17218247.
  11. ↑ van der Weyden L, White JK, Adams DJ, Logan DW (2011). "The mouse genetics toolkit: revealing function and mechanism". Genome Biology. 12 (6): 224. doi:10.1186/gb-2011-12-6-224. PMC 3218837. PMID 21722353.
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