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{{Infobox_gene}}
{{PBB_Controls
'''Long-chain fatty acid transport protein 1''' is a [[protein]] that in humans is encoded by the ''SLC27A1'' [[gene]].<ref name="pmid10873384">{{cite journal | vauthors = Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J | title = The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression | journal = Genomics | volume = 66 | issue = 3 | pages = 296–304 | date = June 2000 | pmid = 10873384 | pmc =  | doi = 10.1006/geno.2000.6191 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=376497| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 27 (fatty acid transporter), member 1
| HGNCid = 10995
| Symbol = SLC27A1
| AltSymbols =; ACSVL5; FATP; FATP1; FLJ00336; MGC71751
| OMIM = 600691
| ECnumber = 
| Homologene = 8063
| MGIid = 1347098
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0003824 |text = catalytic activity}}{{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0006631 |text = fatty acid metabolic process}} {{GNF_GO|id=GO:0006869 |text = lipid transport}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 376497
    | Hs_Ensembl = ENSG00000130304
    | Hs_RefseqProtein = NP_940982
    | Hs_RefseqmRNA = NM_198580
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 17442350
    | Hs_GenLoc_end = 17477977
    | Hs_Uniprot = Q6PCB7
    | Mm_EntrezGene = 26457
    | Mm_Ensembl = ENSMUSG00000031808
    | Mm_RefseqmRNA = NM_011977
    | Mm_RefseqProtein = NP_036107
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 74497916
    | Mm_GenLoc_end = 74515697
    | Mm_Uniprot = Q3TN26
  }}
}}
'''Solute carrier family 27 (fatty acid transporter), member 1''', also known as '''SLC27A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=376497| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Structure ==
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.<ref name="entrez" /> SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.<ref name=COPaKB>]{{cite journal | vauthors = Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P | title = Integration of cardiac proteome biology and medicine by a specialized knowledgebase | journal = Circulation Research | volume = 113 | issue = 9 | pages = 1043–53 | date = October 2013 | pmid = 23965338 | pmc = 4076475 | doi = 10.1161/CIRCRESAHA.113.301151 }}</ref><ref name="url_COPaKB">{{cite web | url = http://www.heartproteome.org/copa/ProteinInfo.aspx?QType=Protein%20ID&QValue=QQ6PCB7 | work = Cardiac Organellar Protein Atlas Knowledgebase (COPaKB) | title = Long-chain fatty acid transport protein 1}}</ref>
 
== See also ==
* {{MeshName|SLC27A1+protein,+human}}
* {{MeshName|SLC27A1+protein,+human}}
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J | title = Lack of association between certain candidate gene polymorphisms and the metabolic syndrome | journal = Molecular Genetics and Metabolism | volume = 86 | issue = 1-2 | pages = 293–9 | year = 2006 | pmid = 15978856 | doi = 10.1016/j.ymgme.2005.05.006 }}
| citations =
* {{cite journal | vauthors = García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM | title = Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells | journal = American Journal of Physiology. Cell Physiology | volume = 288 | issue = 6 | pages = C1264-72 | date = June 2005 | pmid = 15897321 | doi = 10.1152/ajpcell.00271.2004 }}
*{{cite journal | author=Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J |title=Lack of association between certain candidate gene polymorphisms and the metabolic syndrome. |journal=Mol. Genet. Metab. |volume=86 |issue= 1-2 |pages= 293-9 |year= 2006 |pmid= 15978856 |doi= 10.1016/j.ymgme.2005.05.006 }}
* {{cite journal | vauthors = Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM | title = A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution | journal = Atherosclerosis | volume = 167 | issue = 2 | pages = 265–73 | date = April 2003 | pmid = 12818409 | doi = 10.1016/S0021-9150(02)00454-9 }}
*{{cite journal | author=García-Martínez C, Marotta M, Moore-Carrasco R, ''et al.'' |title=Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells. |journal=Am. J. Physiol., Cell Physiol. |volume=288 |issue= 6 |pages= C1264-72 |year= 2005 |pmid= 15897321 |doi= 10.1152/ajpcell.00271.2004 }}
* {{cite journal | vauthors = Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA | title = FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells | journal = Journal of Lipid Research | volume = 43 | issue = 9 | pages = 1380–9 | date = September 2002 | pmid = 12235169 | doi = 10.1194/jlr.M200130-JLR200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Hirsch D, Stahl A, Lodish HF | title = A family of fatty acid transporters conserved from mycobacterium to man | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 15 | pages = 8625–9 | date = July 1998 | pmid = 9671728 | pmc = 21126 | doi = 10.1073/pnas.95.15.8625 }}
*{{cite journal  | author=Gertow K, Skoglund-Andersson C, Eriksson P, ''et al.'' |title=A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution. |journal=Atherosclerosis |volume=167 |issue= 2 |pages= 265-73 |year= 2003 |pmid= 12818409 |doi= }}
* {{cite journal | vauthors = Schaffer JE, Lodish HF | title = Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein | journal = Cell | volume = 79 | issue = 3 | pages = 427–36 | date = November 1994 | pmid = 7954810 | doi = 10.1016/0092-8674(94)90252-6 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Hatch GM, Smith AJ, Xu FY, ''et al.'' |title=FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells. |journal=J. Lipid Res. |volume=43 |issue= 9 |pages= 1380-9 |year= 2003 |pmid= 12235169 |doi=  }}
*{{cite journal  | author=Martin G, Nemoto M, Gelman L, ''et al.'' |title=The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression. |journal=Genomics |volume=66 |issue= 3 |pages= 296-304 |year= 2000 |pmid= 10873384 |doi= 10.1006/geno.2000.6191 }}
*{{cite journal | author=Hirsch D, Stahl A, Lodish HF |title=A family of fatty acid transporters conserved from mycobacterium to man. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 15 |pages= 8625-9 |year= 1998 |pmid= 9671728 |doi= }}
*{{cite journal | author=Schaffer JE, Lodish HF |title=Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein. |journal=Cell |volume=79 |issue= 3 |pages= 427-36 |year= 1994 |pmid= 7954810 |doi= }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Latest revision as of 06:32, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Long-chain fatty acid transport protein 1 is a protein that in humans is encoded by the SLC27A1 gene.[1][2]

Structure

The SLC27A1 gene is located on the 19th chromosome, with its specific location being 19p13.11. The gene contains 15 exons.[2] SLC27A1 encodes a 71.1 kDa protein that is composed of 646 amino acids; 26 peptides have been observed through mass spectrometry data.[3][4]

See also

References

  1. ↑ Martin G, Nemoto M, Gelman L, Geffroy S, Najib J, Fruchart JC, Roevens P, de Martinville B, Deeb S, Auwerx J (June 2000). "The human fatty acid transport protein-1 (SLC27A1; FATP-1) cDNA and gene: organization, chromosomal localization, and expression". Genomics. 66 (3): 296–304. doi:10.1006/geno.2000.6191. PMID 10873384.
  2. ↑ 2.0 2.1 "Entrez Gene: SLC27A1 solute carrier family 27 (fatty acid transporter), member 1".
  3. ↑ ]Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P (October 2013). "Integration of cardiac proteome biology and medicine by a specialized knowledgebase". Circulation Research. 113 (9): 1043–53. doi:10.1161/CIRCRESAHA.113.301151. PMC 4076475. PMID 23965338.
  4. ↑ "Long-chain fatty acid transport protein 1". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB).

Further reading

  • Meirhaeghe A, Cottel D, Amouyel P, Dallongeville J (2006). "Lack of association between certain candidate gene polymorphisms and the metabolic syndrome". Molecular Genetics and Metabolism. 86 (1–2): 293–9. doi:10.1016/j.ymgme.2005.05.006. PMID 15978856.
  • García-Martínez C, Marotta M, Moore-Carrasco R, Guitart M, Camps M, Busquets S, Montell E, Gómez-Foix AM (June 2005). "Impact on fatty acid metabolism and differential localization of FATP1 and FAT/CD36 proteins delivered in cultured human muscle cells". American Journal of Physiology. Cell Physiology. 288 (6): C1264–72. doi:10.1152/ajpcell.00271.2004. PMID 15897321.
  • Gertow K, Skoglund-Andersson C, Eriksson P, Boquist S, Orth-Gomér K, Schenck-Gustafsson K, Hamsten A, Fisher RM (April 2003). "A common polymorphism in the fatty acid transport protein-1 gene associated with elevated post-prandial lipaemia and alterations in LDL particle size distribution". Atherosclerosis. 167 (2): 265–73. doi:10.1016/S0021-9150(02)00454-9. PMID 12818409.
  • Hatch GM, Smith AJ, Xu FY, Hall AM, Bernlohr DA (September 2002). "FATP1 channels exogenous FA into 1,2,3-triacyl-sn-glycerol and down-regulates sphingomyelin and cholesterol metabolism in growing 293 cells". Journal of Lipid Research. 43 (9): 1380–9. doi:10.1194/jlr.M200130-JLR200. PMID 12235169.
  • Hirsch D, Stahl A, Lodish HF (July 1998). "A family of fatty acid transporters conserved from mycobacterium to man". Proceedings of the National Academy of Sciences of the United States of America. 95 (15): 8625–9. doi:10.1073/pnas.95.15.8625. PMC 21126. PMID 9671728.
  • Schaffer JE, Lodish HF (November 1994). "Expression cloning and characterization of a novel adipocyte long chain fatty acid transport protein". Cell. 79 (3): 427–36. doi:10.1016/0092-8674(94)90252-6. PMID 7954810.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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