PLK2: Difference between revisions

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{{Infobox_gene}}
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'''Serine/threonine-protein kinase PLK2''' is an [[enzyme]] that in humans is encoded by the ''PLK2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10769| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Polo-like kinase 2 (Drosophila)
| HGNCid = 19699
| Symbol = PLK2
| AltSymbols =; SNK
| OMIM = 607023
| ECnumber = 
| Homologene = 21317
| MGIid = 1099790
| GeneAtlas_image1 = PBB_GE_PLK2_201939_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0000278 |text = mitotic cell cycle}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0043123 |text = positive regulation of I-kappaB kinase/NF-kappaB cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10769
    | Hs_Ensembl = ENSG00000145632
    | Hs_RefseqProtein = NP_006613
    | Hs_RefseqmRNA = NM_006622
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 57785566
    | Hs_GenLoc_end = 57791844
    | Hs_Uniprot = Q9NYY3
    | Mm_EntrezGene = 20620
    | Mm_Ensembl = ENSMUSG00000021701
    | Mm_RefseqmRNA = NM_152804
    | Mm_RefseqProtein = NP_690017
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 111515940
    | Mm_GenLoc_end = 111521724
    | Mm_Uniprot = Q3TV29
  }}
}}
'''Polo-like kinase 2 (Drosophila)''', also known as '''PLK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10769| accessdate = }}</ref>


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{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10769| accessdate = }}</ref>
| summary_text = Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10769| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Kauselmann G, Weiler M, Wulff P, ''et al.'' |title=The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5528-39 |year= 1999 |pmid= 10523297 |doi= 10.1093/emboj/18.20.5528 }}
*{{cite journal   |vauthors=Kauselmann G, Weiler M, Wulff P, etal |title=The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity. |journal=EMBO J. |volume=18 |issue= 20 |pages= 5528–39 |year= 1999 |pmid= 10523297 |doi= 10.1093/emboj/18.20.5528 | pmc=1171621 }}
*{{cite journal | author=Ouyang B, Li W, Pan H, ''et al.'' |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. |journal=Oncogene |volume=18 |issue= 44 |pages= 6029-36 |year= 1999 |pmid= 10557092 |doi= 10.1038/sj.onc.1202983 }}
*{{cite journal   |vauthors=Ouyang B, Li W, Pan H, etal |title=The physical association and phosphorylation of Cdc25C protein phosphatase by Prk. |journal=Oncogene |volume=18 |issue= 44 |pages= 6029–36 |year= 1999 |pmid= 10557092 |doi= 10.1038/sj.onc.1202983 }}
*{{cite journal | author=Holtrich U, Wolf G, Yuan J, ''et al.'' |title=Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. |journal=Oncogene |volume=19 |issue= 42 |pages= 4832-9 |year= 2000 |pmid= 11039900 |doi= 10.1038/sj.onc.1203845 }}
*{{cite journal   |vauthors=Holtrich U, Wolf G, Yuan J, etal |title=Adhesion induced expression of the serine/threonine kinase Fnk in human macrophages. |journal=Oncogene |volume=19 |issue= 42 |pages= 4832–9 |year= 2000 |pmid= 11039900 |doi= 10.1038/sj.onc.1203845 }}
*{{cite journal | author=Liby K, Wu H, Ouyang B, ''et al.'' |title=Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. |journal=DNA Seq. |volume=11 |issue= 6 |pages= 527-33 |year= 2002 |pmid= 11696980 |doi=  }}
*{{cite journal   |vauthors=Liby K, Wu H, Ouyang B, etal |title=Identification of the human homologue of the early-growth response gene Snk, encoding a serum-inducible kinase. |journal=DNA Seq. |volume=11 |issue= 6 |pages= 527–33 |year= 2002 |pmid= 11696980 |doi=10.3109/10425170109041337 }}
*{{cite journal | author=Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, ''et al.'' |title=Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 491-8 |year= 2002 |pmid= 11716500 |doi= 10.1006/bbrc.2001.5993 }}
*{{cite journal   |vauthors=Shimizu-Yoshida Y, Sugiyama K, Rogounovitch T, etal |title=Radiation-inducible hSNK gene is transcriptionally regulated by p53 binding homology element in human thyroid cells. |journal=Biochem. Biophys. Res. Commun. |volume=289 |issue= 2 |pages= 491–8 |year= 2002 |pmid= 11716500 |doi= 10.1006/bbrc.2001.5993 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Ma S, Liu MA, Yuan YL, Erikson RL |title=The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. |journal=Mol. Cancer Res. |volume=1 |issue= 5 |pages= 376-84 |year= 2003 |pmid= 12651910 |doi=  }}
*{{cite journal  |vauthors=Ma S, Liu MA, Yuan YL, Erikson RL |title=The serum-inducible protein kinase Snk is a G1 phase polo-like kinase that is inhibited by the calcium- and integrin-binding protein CIB. |journal=Mol. Cancer Res. |volume=1 |issue= 5 |pages= 376–84 |year= 2003 |pmid= 12651910 |doi=  }}
*{{cite journal | author=Matsuda A, Suzuki Y, Honda G, ''et al.'' |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307-18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal   |vauthors=Matsuda A, Suzuki Y, Honda G, etal |title=Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. |journal=Oncogene |volume=22 |issue= 21 |pages= 3307–18 |year= 2003 |pmid= 12761501 |doi= 10.1038/sj.onc.1206406 }}
*{{cite journal | author=Burns TF, Fei P, Scata KA, ''et al.'' |title=Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5556-71 |year= 2003 |pmid= 12897130 |doi=  }}
*{{cite journal   |vauthors=Burns TF, Fei P, Scata KA, etal |title=Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5556–71 |year= 2003 |pmid= 12897130 |doi=10.1128/MCB.23.16.5556-5571.2003  | pmc=166320 }}
*{{cite journal  | author=Ma S, Charron J, Erikson RL |title=Role of Plk2 (Snk) in mouse development and cell proliferation. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6936-43 |year= 2003 |pmid= 12972611 |doi=  }}
*{{cite journal  |vauthors=Ma S, Charron J, Erikson RL |title=Role of Plk2 (Snk) in mouse development and cell proliferation. |journal=Mol. Cell. Biol. |volume=23 |issue= 19 |pages= 6936–43 |year= 2003 |pmid= 12972611 |doi=10.1128/MCB.23.19.6936-6943.2003  | pmc=193943 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Yogosawa S, Hatakeyama S, Nakayama KI, ''et al.'' |title=Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41619-27 |year= 2006 |pmid= 16203730 |doi= 10.1074/jbc.M508397200 }}
*{{cite journal   |vauthors=Yogosawa S, Hatakeyama S, Nakayama KI, etal |title=Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase. |journal=J. Biol. Chem. |volume=280 |issue= 50 |pages= 41619–27 |year= 2006 |pmid= 16203730 |doi= 10.1074/jbc.M508397200 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Park YY, Kim SH, Kim YJ, ''et al.'' |title=Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma). |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 1 |pages= 107-13 |year= 2007 |pmid= 17706602 |doi= 10.1016/j.bbrc.2007.07.170 }}
*{{cite journal   |vauthors=Park YY, Kim SH, Kim YJ, etal |title=Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRgamma). |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 1 |pages= 107–13 |year= 2007 |pmid= 17706602 |doi= 10.1016/j.bbrc.2007.07.170 }}
*{{cite journal | author=Matthew EM, Yen TJ, Dicker DT, ''et al.'' |title=Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. |journal=Cell Cycle |volume=6 |issue= 20 |pages= 2571-8 |year= 2007 |pmid= 17912033 |doi=  }}
*{{cite journal   |vauthors=Matthew EM, Yen TJ, Dicker DT, etal |title=Replication stress, defective S-phase checkpoint and increased death in Plk2-deficient human cancer cells. |journal=Cell Cycle |volume=6 |issue= 20 |pages= 2571–8 |year= 2007 |pmid= 17912033 |doi=10.4161/cc.6.20.5079 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Serine/threonine-specific protein kinases}}
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[[Category:EC 2.7.11]]
 
 
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Latest revision as of 18:18, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase PLK2 is an enzyme that in humans is encoded by the PLK2 gene.[1]

Serum-inducible kinase is a member of the 'polo' family of serine/threonine protein kinases that have a role in normal cell division.[supplied by OMIM][1]

References

  1. ↑ 1.0 1.1 "Entrez Gene: PLK2 polo-like kinase 2 (Drosophila)".

Further reading


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