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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Zinc transporter SLC39A7''' (ZIP7) also known as '''solute carrier family 39 member 7''' (SLC39A7) is a [[protein]] that in humans is encoded by the ''SLC39A7'' [[gene]].<ref name="pmid8812499">{{cite journal | vauthors = Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H | title = cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region | journal = Genomics | volume = 35 | issue = 3 | pages = 600–2 |date=Dec 1996 | pmid = 8812499 | pmc =  | doi = 10.1006/geno.1996.0405 }}</ref><ref name="pmid1855816">{{cite journal | vauthors = Hanson IM, Trowsdale J | title = Colinearity of novel genes in the class II regions of the MHC in mouse and human | journal = Immunogenetics | volume = 34 | issue = 1 | pages = 5–11 |date=Aug 1991 | pmid = 1855816 | pmc = | doi =10.1007/BF00212306  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7922| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 39 (zinc transporter), member 7
| HGNCid = 4927
| Symbol = SLC39A7
| AltSymbols =; RING5; D6S115E; D6S2244E; H2-KE4; HKE4; KE4; ZIP7
| OMIM = 601416
| ECnumber = 
| Homologene = 5072
| MGIid = 95909
| GeneAtlas_image1 = PBB_GE_SLC39A7_202667_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0046873 |text = metal ion transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006829 |text = zinc ion transport}} {{GNF_GO|id=GO:0030001 |text = metal ion transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7922
    | Hs_Ensembl = ENSG00000112473
    | Hs_RefseqProtein = NP_001070984
    | Hs_RefseqmRNA = NM_001077516
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 33276631
    | Hs_GenLoc_end = 33280192
    | Hs_Uniprot = Q92504
    | Mm_EntrezGene = 14977
    | Mm_Ensembl = ENSMUSG00000024327
    | Mm_RefseqmRNA = NM_001077709
    | Mm_RefseqProtein = NP_001071177
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 33638727
    | Mm_GenLoc_end = 33642012
    | Mm_Uniprot = Q14C53
  }}
}}
'''Solute carrier family 39 (zinc transporter), member 7''', also known as '''SLC39A7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7922| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Zinc]] is an essential [[cofactor (biochemistry)|cofactor]] for more than 50 classes of [[enzyme]]s. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of [[gene transcription]], growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the [[cytosol]] from both the extracellular environment and from intracellular storage compartments.<ref name="entrez" />
{{PBB_Summary
 
| section_title =
ZIP7 is a [[membrane transport protein]] of the [[endoplasmic reticulum]].<ref>{{Cite journal
| summary_text = Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7922| accessdate = }}</ref>
| vauthors = Taylor KM, Morgan HE, Johnson A, Nicholson RI
}}
| title = Structure‒function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters
| doi = 10.1042/BJ20031183
| journal = Biochemical Journal
| volume = 377
| issue = Pt 1
| pages = 131–139
| year = 2004
| pmid = 14525538
| pmc =1223853
}}</ref> Phosphorylation of ZIP7 by [[casein kinase 2]] stimulates the release of [[zinc]] ions from the endoplasmic reticulum<ref>{{Cite journal
| vauthors = Taylor KM, Kille P, Hogstrand C
| doi = 10.4161/cc.20414
| title = Protein kinase CK2 opens the gate for zinc signaling
| journal = Cell Cycle
| volume = 11
| issue = 10
| pages = 1863–1864
| year = 2012
| pmid = 22580452
| pmc =3359116
}}</ref> This provides a [[signal transduction]] pathway by which activation of cell surface receptors such as the [[epidermal growth factor receptor]] can regulate the activity of downstream [[phosphatase]]s and [[kinase]]s.


==See also==
==See also==
Line 58: Line 34:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
| citations =
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Hanson IM, Trowsdale J |title=Colinearity of novel genes in the class II regions of the MHC in mouse and human. |journal=Immunogenetics |volume=34 |issue= 1 |pages= 5-11 |year= 1991 |pmid= 1855816 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal   |vauthors=Taylor KM, Morgan HE, Johnson A, etal |title=Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters |journal=Biochem. J. |volume=375 |issue= Pt 1 |pages= 51–9 |year= 2003 |pmid= 12839489 |doi= 10.1042/BJ20030478 | pmc=1223660 }}
*{{cite journal  | author=Ando A, Kikuti YY, Shigenari A, ''et al.'' |title=cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region. |journal=Genomics |volume=35 |issue= 3 |pages= 600-2 |year= 1996 |pmid= 8812499 |doi= 10.1006/geno.1996.0405 }}
*{{cite journal  | vauthors=Taylor KM, Morgan HE, Johnson A, Nicholson RI |title=Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters |journal=Biochem. J. |volume=377 |issue= Pt 1 |pages= 131–9 |year= 2004 |pmid= 14525538 |doi= 10.1042/BJ20031183 | pmc=1223853 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6 |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Taylor KM, Morgan HE, Johnson A, ''et al.'' |title=Structure-function analysis of LIV-1, the breast cancer-associated protein that belongs to a new subfamily of zinc transporters. |journal=Biochem. J. |volume=375 |issue= Pt 1 |pages= 51-9 |year= 2003 |pmid= 12839489 |doi= 10.1042/BJ20030478 }}
*{{cite journal  | vauthors=Huang L, Kirschke CP, Zhang Y, Yu YY |title=The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15456–63 |year= 2005 |pmid= 15705588 |doi= 10.1074/jbc.M412188200 }}
*{{cite journal  | author=Taylor KM, Morgan HE, Johnson A, Nicholson RI |title=Structure-function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters. |journal=Biochem. J. |volume=377 |issue= Pt 1 |pages= 131-9 |year= 2004 |pmid= 14525538 |doi= 10.1042/BJ20031183 }}
*{{cite journal  | vauthors=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Ewing RM, Chu P, Elisma F, etal |title=Large-scale mapping of human protein–protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue=  1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 }}
*{{cite journal  | author=Huang L, Kirschke CP, Zhang Y, Yu YY |title=The ZIP7 gene (Slc39a7) encodes a zinc transporter involved in zinc homeostasis of the Golgi apparatus. |journal=J. Biol. Chem. |volume=280 |issue= 15 |pages= 15456-63 |year= 2005 |pmid= 15705588 |doi= 10.1074/jbc.M412188200 }}
*{{cite journal  | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339-46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue=  |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:33, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Zinc transporter SLC39A7 (ZIP7) also known as solute carrier family 39 member 7 (SLC39A7) is a protein that in humans is encoded by the SLC39A7 gene.[1][2][3]

Function

Zinc is an essential cofactor for more than 50 classes of enzymes. It is involved in protein, nucleic acid, carbohydrate, and lipid metabolism, as well as in the control of gene transcription, growth, development, and differentiation. Zinc cannot passively diffuse across cell membranes and requires specific transporters, such as SLC39A7, to enter the cytosol from both the extracellular environment and from intracellular storage compartments.[3]

ZIP7 is a membrane transport protein of the endoplasmic reticulum.[4] Phosphorylation of ZIP7 by casein kinase 2 stimulates the release of zinc ions from the endoplasmic reticulum[5] This provides a signal transduction pathway by which activation of cell surface receptors such as the epidermal growth factor receptor can regulate the activity of downstream phosphatases and kinases.

See also

References

  1. ↑ Ando A, Kikuti YY, Shigenari A, Kawata H, Okamoto N, Shiina T, Chen L, Ikemura T, Abe K, Kimura M, Inoko H (Dec 1996). "cDNA cloning of the human homologues of the mouse Ke4 and Ke6 genes at the centromeric end of the human MHC region". Genomics. 35 (3): 600–2. doi:10.1006/geno.1996.0405. PMID 8812499.
  2. ↑ Hanson IM, Trowsdale J (Aug 1991). "Colinearity of novel genes in the class II regions of the MHC in mouse and human". Immunogenetics. 34 (1): 5–11. doi:10.1007/BF00212306. PMID 1855816.
  3. ↑ 3.0 3.1 "Entrez Gene: SLC39A7 solute carrier family 39 (zinc transporter), member 7".
  4. ↑ Taylor KM, Morgan HE, Johnson A, Nicholson RI (2004). "Structure‒function analysis of HKE4, a member of the new LIV-1 subfamily of zinc transporters". Biochemical Journal. 377 (Pt 1): 131–139. doi:10.1042/BJ20031183. PMC 1223853. PMID 14525538.
  5. ↑ Taylor KM, Kille P, Hogstrand C (2012). "Protein kinase CK2 opens the gate for zinc signaling". Cell Cycle. 11 (10): 1863–1864. doi:10.4161/cc.20414. PMC 3359116. PMID 22580452.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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