SLC22A7: Difference between revisions

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Revision as of 06:28, 11 September 2017

Solute carrier family 22 member 7 is a protein that in humans is encoded by the SLC22A7 gene.^[1]^[2]^[3]

The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.^[3]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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<imagemap> Image:FluoropyrimidineActivity_WP1601.png

|{{{bSize}}}px|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

↑ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

References

↑ Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID 9650585.
↑ Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID 10773670.
↑ ^3.0 ^3.1 "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

Cropp CD, Komori T, Shima JE, et al. (2008). "Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP". Mol. Pharmacol. 73 (4): 1151–8. doi:10.1124/mol.107.043117. PMC 2698938. PMID 18216183.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Enomoto A, Takeda M, Shimoda M, et al. (2002). "Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors". J. Pharmacol. Exp. Ther. 301 (3): 797–802. doi:10.1124/jpet.301.3.797. PMID 12023506.
Kimura H, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins". J. Pharmacol. Exp. Ther. 301 (1): 293–8. doi:10.1124/jpet.301.1.293. PMID 11907186.
Babu E, Takeda M, Narikawa S, et al. (2002). "Human organic anion transporters mediate the transport of tetracycline". Jpn. J. Pharmacol. 88 (1): 69–76. doi:10.1254/jjp.88.69. PMID 11855680.
Sun W, Wu RR, van Poelje PD, Erion MD (2001). "Isolation of a family of organic anion transporters from human liver and kidney". Biochem. Biophys. Res. Commun. 283 (2): 417–22. doi:10.1006/bbrc.2001.4774. PMID 11327718.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-4] The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

[pmid9650585-1] Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H (Jul 1998). "Identification of multispecific organic anion transporter 2 expressed predominantly in the liver". FEBS Lett. 429 (2): 179–82. doi:10.1016/S0014-5793(98)00585-7. PMID 9650585.

[pmid10773670-2] Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM (Jun 2000). "Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids". Cytogenet Cell Genet. 88 (1–2): 76–7. doi:10.1159/000015489. PMID 10773670.

[entrez-3] 3.0 ^3.1 "Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7".

[1]

[2]

[3]

[§ 1]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Underlinked|date=June 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Solute carrier family 22 member 7''' is a [[protein]] that in humans is encoded by the ''SLC22A7'' [[gene]].<ref name="pmid9650585">{{cite journal | vauthors = Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H | title = Identification of multispecific organic anion transporter 2 expressed predominantly in the liver | journal = FEBS Lett | volume = 429 | issue = 2 | pages = 179–82 | date = Jul 1998 | pmid = 9650585 | pmc =  | doi =10.1016/S0014-5793(98)00585-7  }}</ref><ref name="pmid10773670">{{cite journal | vauthors = Kok LD, Siu SS, Fung KP, Tsui SK, Lee CY, Waye MM | title = Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2→p21.1 using radiation hybrids | journal = Cytogenet Cell Genet | volume = 88 | issue = 1–2 | pages = 76–7 | date = Jun 2000 | pmid = 10773670 | pmc =  | doi =10.1159/000015489  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 22 (organic anion transporter), member 7
- | HGNCid = 10971
- | Symbol = SLC22A7
- | AltSymbols =; MGC24091; MGC45202; NLT; OAT2
- | OMIM = 604995
- | ECnumber =
- | Homologene = 21328
- | MGIid = 1859559
- | GeneAtlas_image1 = PBB_GE_SLC22A7_220554_at_tn.png
- | GeneAtlas_image2 = PBB_GE_SLC22A7_221661_at_tn.png
- | GeneAtlas_image3 = PBB_GE_SLC22A7_221662_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}}{{GNF_GO|id=GO:0005215 |text = transporter activity}}{{GNF_GO|id=GO:0005524 |text = ATP binding}}{{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}}{{GNF_GO|id=GO:0015293 |text = symporter activity}}{{GNF_GO|id=GO:0015347 |text = sodium-independent organic anion transmembrane transporter activity}}{{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
-  | Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0015711 |text = organic anion transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10864
-    | Hs_Ensembl = ENSG00000137204
-    | Hs_RefseqProtein = NP_006663
-    | Hs_RefseqmRNA = NM_006672
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 6
-    | Hs_GenLoc_start = 43373977
-    | Hs_GenLoc_end = 43381254
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 108114
-    | Mm_Ensembl = ENSMUSG00000067144
-    | Mm_RefseqmRNA = XM_001002761
-    | Mm_RefseqProtein = XP_001002761
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 17
-    | Mm_GenLoc_start = 45895372
-    | Mm_GenLoc_end = 45901620
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 22 (organic anion transporter), member 7''', also known as '''SLC22A7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A7 solute carrier family 22 (organic anion transporter), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10864| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described.<ref name="entrez"/>
 }}
+== Interactive pathway map ==
+{{FluoropyrimidineActivity WP1601|highlight=SLC22A7}}
 ==See also==
-* {{MeshName|SLC22A7+protein,+human}}
+*{{MeshName|SLC22A7+protein,+human}}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 65: / Line 22: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Cropp CD, Komori T, Shima JE, ''et al.'' |title=Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. |journal=Mol. Pharmacol. |volume=73 |issue= 4 |pages= 1151-8 |year= 2008 |pmid= 18216183 |doi= 10.1124/mol.107.043117 }}
+*{{cite journal   |vauthors=Cropp CD, Komori T, Shima JE, etal |title=Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP |journal=Mol. Pharmacol. |volume=73 |issue= 4 |pages= 1151–8 |year= 2008 |pmid= 18216183 |doi= 10.1124/mol.107.043117  | pmc=2698938 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Enomoto A, Takeda M, Shimoda M, ''et al.'' |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797-802 |year= 2002 |pmid= 12023506 |doi=  }}
+*{{cite journal   |vauthors=Enomoto A, Takeda M, Shimoda M, etal |title=Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 3 |pages= 797–802 |year= 2002 |pmid= 12023506 |doi=10.1124/jpet.301.3.797  }}
-*{{cite journal  | author=Kimura H, Takeda M, Narikawa S, ''et al.'' |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293-8 |year= 2002 |pmid= 11907186 |doi=  }}
+*{{cite journal   |vauthors=Kimura H, Takeda M, Narikawa S, etal |title=Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins |journal=J. Pharmacol. Exp. Ther. |volume=301 |issue= 1 |pages= 293–8 |year= 2002 |pmid= 11907186 |doi=10.1124/jpet.301.1.293  }}
-*{{cite journal  | author=Babu E, Takeda M, Narikawa S, ''et al.'' |title=Human organic anion transporters mediate the transport of tetracycline. |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69-76 |year= 2002 |pmid= 11855680 |doi=  }}
+*{{cite journal   |vauthors=Babu E, Takeda M, Narikawa S, etal |title=Human organic anion transporters mediate the transport of tetracycline |journal=Jpn. J. Pharmacol. |volume=88 |issue= 1 |pages= 69–76 |year= 2002 |pmid= 11855680 |doi=10.1254/jjp.88.69  }}
-*{{cite journal  | author=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney. |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417-22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
+*{{cite journal  | vauthors=Sun W, Wu RR, van Poelje PD, Erion MD |title=Isolation of a family of organic anion transporters from human liver and kidney |journal=Biochem. Biophys. Res. Commun. |volume=283 |issue= 2 |pages= 417–22 |year= 2001 |pmid= 11327718 |doi= 10.1006/bbrc.2001.4774 }}
-*{{cite journal  | author=Kok LD, Siu SS, Fung KP, ''et al.'' |title=Assignment of liver-specific organic anion transporter (SLC22A7) to human chromosome 6 bands p21.2-->p21.1 using radiation hybrids. |journal=Cytogenet. Cell Genet. |volume=88 |issue= 1-2 |pages= 76-7 |year= 2000 |pmid= 10773670 |doi=  }}
-*{{cite journal  | author=Sekine T, Cha SH, Tsuda M, ''et al.'' |title=Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. |journal=FEBS Lett. |volume=429 |issue= 2 |pages= 179-82 |year= 1998 |pmid= 9650585 |doi=  }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{NLM content}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC22A7: Difference between revisions

Revision as of 06:28, 11 September 2017

Contents

Interactive pathway map

See also

References

Further reading

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