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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(q) subunit alpha''' is a [[protein]] that in humans is encoded by the ''GNAQ'' [[gene]].<ref name="pmid8825633">{{cite journal | vauthors = Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J | title = Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene | journal = Genomics | volume = 30 | issue = 3 | pages = 470–75 | date = February 1997 | pmid = 8825633 | pmc = | doi = 10.1006/geno.1995.1267 }}</ref> Together with [[GNA11]] (its [[paralogue]]), it functions as a [[Gq alpha subunit]].<ref>[http://www.omim.org/entry/139313 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11] at [[OMIM]]. Retrieved January 1, 2015.</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
{{Further|Gq alpha subunit}}
| image = PBB_Protein_GNAQ_image.jpg
Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2776| accessdate = }}</ref>
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2bcj.
| PDB = {{PDB2|2bcj}}
| Name = Guanine nucleotide binding protein (G protein), q polypeptide
| HGNCid = 4390
| Symbol = GNAQ
| AltSymbols =; G-ALPHA-q; GAQ
| OMIM = 600998
| ECnumber = 
| Homologene = 1566
| MGIid = 95776
| GeneAtlas_image1 = PBB_GE_GNAQ_202615_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNAQ_211426_x_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005834 |text = heterotrimeric G-protein complex}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0001501 |text = skeletal development}} {{GNF_GO|id=GO:0001508 |text = regulation of action potential}} {{GNF_GO|id=GO:0006471 |text = protein amino acid ADP-ribosylation}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007189 |text = G-protein signaling, adenylate cyclase activating pathway}} {{GNF_GO|id=GO:0007202 |text = phospholipase C activation}} {{GNF_GO|id=GO:0007215 |text = glutamate signaling pathway}} {{GNF_GO|id=GO:0007507 |text = heart development}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0016322 |text = neuron remodeling}} {{GNF_GO|id=GO:0042733 |text = embryonic digit morphogenesis}} {{GNF_GO|id=GO:0045634 |text = regulation of melanocyte differentiation}} {{GNF_GO|id=GO:0048066 |text = pigmentation during development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2776
    | Hs_Ensembl = ENSG00000156052
    | Hs_RefseqProtein = NP_002063
    | Hs_RefseqmRNA = NM_002072
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 79520823
    | Hs_GenLoc_end = 79836194
    | Hs_Uniprot = P50148
    | Mm_EntrezGene = 14682
    | Mm_Ensembl = ENSMUSG00000024639
    | Mm_RefseqmRNA = NM_008139
    | Mm_RefseqProtein = NP_032165
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 19
    | Mm_GenLoc_start = 16199850
    | Mm_GenLoc_end = 16454472
    | Mm_Uniprot = Q3UHH5
  }}
}}
'''Guanine nucleotide binding protein (G protein), q polypeptide''', also known as '''GNAQ''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
Mutations in this gene have been found associated to cases of [[Sturge-Weber syndrome]] and [[port-wine stain]]s.<ref>{{cite journal | vauthors = Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J | title = Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ. | journal = The New England Journal of Medicine | volume = 368 | issue = 21 | pages = 1971–9 | date = May 23, 2013 | pmid = 23656586 | doi = 10.1056/NEJMoa1213507 | pmc=3749068}}</ref>
{{PBB_Summary
| section_title =  
| summary_text = Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2776| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
GNAQ has been shown to [[Protein-protein interaction|interact]] with:
* [[Beta adrenergic receptor kinase]],<ref name = pmid12885252>{{cite journal | vauthors = Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB | title = Differential interaction of GRK2 with members of the G alpha q family | journal = Biochemistry | volume = 42 | issue = 30 | pages = 9176–84 | date = August 2003 | pmid = 12885252 | doi = 10.1021/bi034442+ }}</ref>
* [[Bruton's tyrosine kinase]],<ref name = pmid9770463>{{cite journal | vauthors = Ma YC, Huang XY | title = Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 21 | pages = 12197–201 | date = October 1998 | pmid = 9770463 | pmc = 22808 | doi =  10.1073/pnas.95.21.12197}}</ref>
* [[RGS16]],<ref name = pmid14634662><!-- Generated with pubmed2wiki.xsl Author: Pierre Lindenbaum PhD. plindenbaum@yahoo.fr http://en.wikipedia.org/wiki/User:Plindenbaum --></ref>
* [[RGS4]]<ref name = pmid14634662/><ref name = pmid9660808>{{cite journal | vauthors = Druey KM, Sullivan BM, Brown D, Fischer ER, Watson N, Blumer KJ, Gerfen CR, Scheschonka A, Kehrl JH | title = Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane | journal = J. Biol. Chem. | volume = 273 | issue = 29 | pages = 18405–10 | date = July 1998 | pmid = 9660808 | doi =  10.1074/jbc.273.29.18405}}</ref>
* [[RIC8A]],<ref name = pmid12652642>{{cite journal | vauthors = Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, García MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J | title = Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol | journal = J. Cell. Physiol. | volume = 195 | issue = 2 | pages = 151–7 | date = May 2003 | pmid = 12652642 | doi = 10.1002/jcp.10300 }}</ref><ref name = pmid12509430>{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = J. Biol. Chem. | volume = 278 | issue = 10 | pages = 8356–62 | date = March 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>  and
* [[Sodium-hydrogen antiporter 3 regulator 1]].<ref name = pmid12193606>{{cite journal | vauthors = Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, Parent JL | title = Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50) | journal = J. Biol. Chem. | volume = 277 | issue = 43 | pages = 40751–9 | date = October 2002 | pmid = 12193606 | doi = 10.1074/jbc.M207910200 }}</ref>
 
== See also ==
* [[List of genes mutated in pigmented cutaneous lesions]]
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Raymond JR, Mukhin YV, Gelasco A, Turner J, Collinsworth G, Gettys TW, Grewal JS, Garnovskaya MN | title = Multiplicity of mechanisms of serotonin receptor signal transduction. | journal = Pharmacol. Ther. | volume = 92 | issue = 2–3 | pages = 179–212 | year = 2002 | pmid = 11916537 | doi = 10.1016/S0163-7258(01)00169-3 }}
| citations =
* {{cite journal | vauthors = Van Oekelen D, Luyten WH, Leysen JE | title = 5-HT2A and 5-HT2C receptors and their atypical regulation properties. | journal = Life Sci. | volume = 72 | issue = 22 | pages = 2429–49 | year = 2003 | pmid = 12650852 | doi = 10.1016/S0024-3205(03)00141-3 }}
*{{cite journal | author=Raymond JR, Mukhin YV, Gelasco A, ''et al.'' |title=Multiplicity of mechanisms of serotonin receptor signal transduction. |journal=Pharmacol. Ther. |volume=92 |issue= 2-3 |pages= 179-212 |year= 2002 |pmid= 11916537 |doi= }}
* {{cite journal | vauthors = Lesch KP, Manji HK | title = Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain. | journal = Biol. Psychiatry | volume = 32 | issue = 7 | pages = 549–79 | year = 1992 | pmid = 1333286 | doi = 10.1016/0006-3223(92)90070-G }}
*{{cite journal | author=Van Oekelen D, Luyten WH, Leysen JE |title=5-HT2A and 5-HT2C receptors and their atypical regulation properties. |journal=Life Sci. |volume=72 |issue= 22 |pages= 2429-49 |year= 2003 |pmid= 12650852 |doi= }}
* {{cite journal | vauthors = Thomas CP, Dunn MJ, Mattera R | title = Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. | journal = Biochem. J. | volume = ( Pt 1) | issue =  | pages = 151–8 | year = 1996 | pmid = 7492305 | pmc = 1136238 | doi =  | series = 312 }}
*{{cite journal | author=Lesch KP, Manji HK |title=Signal-transducing G proteins and antidepressant drugs: evidence for modulation of alpha subunit gene expression in rat brain. |journal=Biol. Psychiatry |volume=32 |issue= 7 |pages= 549-79 |year= 1992 |pmid= 1333286 |doi= }}
* {{cite journal | vauthors = Blin N, Yun J, Wess J | title = Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. | journal = J. Biol. Chem. | volume = 270 | issue = 30 | pages = 17741–8 | year = 1995 | pmid = 7629074 | doi = 10.1074/jbc.270.30.17741 }}
*{{cite journal | author=Thomas CP, Dunn MJ, Mattera R |title=Ca2+ signalling in K562 human erythroleukaemia cells: effect of dimethyl sulphoxide and role of G-proteins in thrombin- and thromboxane A2-activated pathways. |journal=Biochem. J. |volume=312 ( Pt 1) |issue=  |pages= 151-8 |year= 1996 |pmid= 7492305 |doi=  }}
* {{cite journal | vauthors = Kabouridis PS, Waters ST, Escobar S, Stanners J, Tsoukas CD | title = Expression of GTP-binding protein alpha subunits in human thymocytes. | journal = Mol. Cell. Biochem. | volume = 144 | issue = 1 | pages = 45–51 | year = 1995 | pmid = 7791744 | doi = 10.1007/BF00926739 }}
*{{cite journal | author=Blin N, Yun J, Wess J |title=Mapping of single amino acid residues required for selective activation of Gq/11 by the m3 muscarinic acetylcholine receptor. |journal=J. Biol. Chem. |volume=270 |issue= 30 |pages= 17741-8 |year= 1995 |pmid= 7629074 |doi= }}
* {{cite journal | vauthors = Allgeier A, Offermanns S, Van Sande J, Spicher K, Schultz G, Dumont JE | title = The human thyrotropin receptor activates G-proteins Gs and Gq/11. | journal = J. Biol. Chem. | volume = 269 | issue = 19 | pages = 13733–5 | year = 1994 | pmid = 8188646 | doi =  }}
*{{cite journal | author=Kabouridis PS, Waters ST, Escobar S, ''et al.'' |title=Expression of GTP-binding protein alpha subunits in human thymocytes. |journal=Mol. Cell. Biochem. |volume=144 |issue= 1 |pages= 45-51 |year= 1995 |pmid= 7791744 |doi= }}
* {{cite journal | vauthors = Wedegaertner PB, Chu DH, Wilson PT, Levis MJ, Bourne HR | title = Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. | journal = J. Biol. Chem. | volume = 268 | issue = 33 | pages = 25001–8 | year = 1993 | pmid = 8227063 | doi =  }}
*{{cite journal | author=Allgeier A, Offermanns S, Van Sande J, ''et al.'' |title=The human thyrotropin receptor activates G-proteins Gs and Gq/11. |journal=J. Biol. Chem. |volume=269 |issue= 19 |pages= 13733-5 |year= 1994 |pmid= 8188646 |doi=  }}
* {{cite journal | vauthors = Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A | title = Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. | journal = Endocrinology | volume = 132 | issue = 6 | pages = 2484–90 | year = 1993 | pmid = 8504751 | doi = 10.1210/en.132.6.2484 }}
*{{cite journal | author=Wedegaertner PB, Chu DH, Wilson PT, ''et al.'' |title=Palmitoylation is required for signaling functions and membrane attachment of Gq alpha and Gs alpha. |journal=J. Biol. Chem. |volume=268 |issue= 33 |pages= 25001-8 |year= 1993 |pmid= 8227063 |doi=  }}
* {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 1 | pages = 116–20 | year = 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 }}
*{{cite journal | author=Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A |title=Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. |journal=Endocrinology |volume=132 |issue= 6 |pages= 2484-90 |year= 1993 |pmid= 8504751 |doi= }}
* {{cite journal | vauthors = Denker SP, McCaffery JM, Palade GE, Insel PA, Farquhar MG | title = Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. | journal = J. Cell Biol. | volume = 133 | issue = 5 | pages = 1027–40 | year = 1996 | pmid = 8655576 | pmc = 2120853 | doi = 10.1083/jcb.133.5.1027 }}
*{{cite journal | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116-20 |year= 1996 |pmid= 8552586 |doi= }}
* {{cite journal | vauthors = Chen B, Leverette RD, Schwinn DA, Kwatra MM | title = Human G(alpha q): cDNA and tissue distribution. | journal = Biochim. Biophys. Acta | volume = 1281 | issue = 2 | pages = 125–8 | year = 1996 | pmid = 8664309 | doi = 10.1016/0005-2736(96)00039-9 }}
*{{cite journal | author=Denker SP, McCaffery JM, Palade GE, ''et al.'' |title=Differential distribution of alpha subunits and beta gamma subunits of heterotrimeric G proteins on Golgi membranes of the exocrine pancreas. |journal=J. Cell Biol. |volume=133 |issue= 5 |pages= 1027-40 |year= 1996 |pmid= 8655576 |doi= }}
* {{cite journal | vauthors = Johnson GJ, Leis LA, Dunlop PC | title = Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. | journal = Biochem. J. | volume = ( Pt 3) | issue = | pages = 1023–31 | year = 1996 | pmid = 8836152 | pmc = 1217719 | doi = | series = 318 }}
*{{cite journal | author=Chen B, Leverette RD, Schwinn DA, Kwatra MM |title=Human G(alpha q): cDNA and tissue distribution. |journal=Biochim. Biophys. Acta |volume=1281 |issue= 2 |pages= 125-8 |year= 1996 |pmid= 8664309 |doi= }}
* {{cite journal | vauthors = Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, Pin JP | title = Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. | journal = Mol. Pharmacol. | volume = 50 | issue = 4 | pages = 923–30 | year = 1996 | pmid = 8863838 | doi =  }}
*{{cite journal | author=Dong Q, Shenker A, Way J, ''et al.'' |title=Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene. |journal=Genomics |volume=30 |issue= 3 |pages= 470-75 |year= 1997 |pmid= 8825633 |doi= 10.1006/geno.1995.1267 }}
* {{cite journal | vauthors = Petit A, Geoffroy P, Bélisle S | title = Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta. | journal = J. Soc. Gynecol. Investig. | volume = 3 | issue = 6 | pages = 316–21 | year = 1997 | pmid = 8923415 | doi = 10.1016/S1071-5576(96)00035-4 }}
*{{cite journal | author=Johnson GJ, Leis LA, Dunlop PC |title=Specificity of G alpha q and G alpha 11 gene expression in platelets and erythrocytes. Expressions of cellular differentiation and species differences. |journal=Biochem. J. |volume=318 ( Pt 3) |issue= |pages= 1023-31 |year= 1996 |pmid= 8836152 |doi=  }}
* {{cite journal | vauthors = Petit A, Geoffroy P, Bélisle S | title = Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension. | journal = Life Sci. | volume = 60 | issue = 12 | pages = 953–60 | year = 1997 | pmid = 9061052 | doi = 10.1016/S0024-3205(96)00654-6 }}
*{{cite journal | author=Gomeza J, Mary S, Brabet I, ''et al.'' |title=Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. |journal=Mol. Pharmacol. |volume=50 |issue= 4 |pages= 923-30 |year= 1996 |pmid= 8863838 |doi= }}
* {{cite journal | vauthors = Kinsella BT, O'Mahony DJ, Fitzgerald GA | title = The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. | journal = J. Pharmacol. Exp. Ther. | volume = 281 | issue = 2 | pages = 957–64 | year = 1997 | pmid = 9152406 | doi =  }}
*{{cite journal | author=Petit A, Geoffroy P, Bélisle S |title=Expression of angiotensin II type-I receptor and phospholipase C-linked G alpha q/11 protein in the human placenta. |journal=J. Soc. Gynecol. Investig. |volume=3 |issue= 6 |pages= 316-21 |year= 1997 |pmid= 8923415 |doi= }}
* {{cite journal | vauthors = Wise A, Parenti M, Milligan G | title = Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. | journal = FEBS Lett. | volume = 407 | issue = 3 | pages = 257–60 | year = 1997 | pmid = 9175863 | doi = 10.1016/S0014-5793(97)00300-1 }}
*{{cite journal | author=Petit A, Geoffroy P, Bélisle S |title=Expression of G proteins in human placentas from pregnancies complicated by gestational hypertension. |journal=Life Sci. |volume=60 |issue= 12 |pages= 953-60 |year= 1997 |pmid= 9061052 |doi=  }}
* {{cite journal | vauthors = Gabbeta J, Yang X, Kowalska MA, Sun L, Dhanasekaran N, Rao AK | title = Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 16 | pages = 8750–5 | year = 1997 | pmid = 9238049 | pmc = 23110 | doi = 10.1073/pnas.94.16.8750 }}
*{{cite journal | author=Kinsella BT, O'Mahony DJ, Fitzgerald GA |title=The human thromboxane A2 receptor alpha isoform (TP alpha) functionally couples to the G proteins Gq and G11 in vivo and is activated by the isoprostane 8-epi prostaglandin F2 alpha. |journal=J. Pharmacol. Exp. Ther. |volume=281 |issue= 2 |pages= 957-64 |year= 1997 |pmid= 9152406 |doi= }}
*{{cite journal | author=Wise A, Parenti M, Milligan G |title=Interaction of the G-protein G11alpha with receptors and phosphoinositidase C: the contribution of G-protein palmitoylation and membrane association. |journal=FEBS Lett. |volume=407 |issue= 3 |pages= 257-60 |year= 1997 |pmid= 9175863 |doi= }}
*{{cite journal  | author=Gabbeta J, Yang X, Kowalska MA, ''et al.'' |title=Platelet signal transduction defect with Galpha subunit dysfunction and diminished Galphaq in a patient with abnormal platelet responses. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 16 |pages= 8750-5 |year= 1997 |pmid= 9238049 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=2776}}
{{Intracellular signaling peptides and proteins}}
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Latest revision as of 08:50, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(q) subunit alpha is a protein that in humans is encoded by the GNAQ gene.[1] Together with GNA11 (its paralogue), it functions as a Gq alpha subunit.[2]

Function

Further information: Gq alpha subunit

Guanine nucleotide-binding proteins are a family of heterotrimeric proteins that couple cell surface, 7-transmembrane domain receptors to intracellular signaling pathways. Receptor activation catalyzes the exchange of GDP for GTP bound to the inactive G protein alpha subunit resulting in a conformational change and dissociation of the complex. The G protein alpha and beta-gamma subunits are capable of regulating various cellular effectors. Activation is terminated by a GTPase intrinsic to the G-alpha subunit. G-alpha-q is the alpha subunit of one of the heterotrimeric GTP-binding proteins that mediates stimulation of phospholipase C-beta (MIM 600230).[supplied by OMIM][3]

Mutations in this gene have been found associated to cases of Sturge-Weber syndrome and port-wine stains.[4]

Interactions

GNAQ has been shown to interact with:

See also

References

  1. ↑ Dong Q, Shenker A, Way J, Haddad BR, Lin K, Hughes MR, McBride OW, Spiegel AM, Battey J (February 1997). "Molecular cloning of human G alpha q cDNA and chromosomal localization of the G alpha q gene (GNAQ) and a processed pseudogene". Genomics. 30 (3): 470–75. doi:10.1006/geno.1995.1267. PMID 8825633.
  2. ↑ 139313 GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-11; GNA11 at OMIM. Retrieved January 1, 2015.
  3. ↑ "Entrez Gene: GNAQ guanine nucleotide binding protein (G protein), q polypeptide".
  4. ↑ Shirley MD, Tang H, Gallione CJ, Baugher JD, Frelin LP, Cohen B, North PE, Marchuk DA, Comi AM, Pevsner J (May 23, 2013). "Sturge-Weber syndrome and port-wine stains caused by somatic mutation in GNAQ". The New England Journal of Medicine. 368 (21): 1971–9. doi:10.1056/NEJMoa1213507. PMC 3749068. PMID 23656586.
  5. ↑ Day PW, Carman CV, Sterne-Marr R, Benovic JL, Wedegaertner PB (August 2003). "Differential interaction of GRK2 with members of the G alpha q family". Biochemistry. 42 (30): 9176–84. doi:10.1021/bi034442+. PMID 12885252.
  6. ↑ Ma YC, Huang XY (October 1998). "Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase". Proc. Natl. Acad. Sci. U.S.A. 95 (21): 12197–201. doi:10.1073/pnas.95.21.12197. PMC 22808. PMID 9770463.
  7. ↑ 7.0 7.1
  8. ↑ Druey KM, Sullivan BM, Brown D, Fischer ER, Watson N, Blumer KJ, Gerfen CR, Scheschonka A, Kehrl JH (July 1998). "Expression of GTPase-deficient Gialpha2 results in translocation of cytoplasmic RGS4 to the plasma membrane". J. Biol. Chem. 273 (29): 18405–10. doi:10.1074/jbc.273.29.18405. PMID 9660808.
  9. ↑ Klattenhoff C, Montecino M, Soto X, Guzmán L, Romo X, García MA, Mellstrom B, Naranjo JR, Hinrichs MV, Olate J (May 2003). "Human brain synembryn interacts with Gsalpha and Gqalpha and is translocated to the plasma membrane in response to isoproterenol and carbachol". J. Cell. Physiol. 195 (2): 151–7. doi:10.1002/jcp.10300. PMID 12652642.
  10. ↑ Tall GG, Krumins AM, Gilman AG (March 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". J. Biol. Chem. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  11. ↑ Rochdi MD, Watier V, La Madeleine C, Nakata H, Kozasa T, Parent JL (October 2002). "Regulation of GTP-binding protein alpha q (Galpha q) signaling by the ezrin-radixin-moesin-binding phosphoprotein-50 (EBP50)". J. Biol. Chem. 277 (43): 40751–9. doi:10.1074/jbc.M207910200. PMID 12193606.

Further reading

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