MELK: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
(consistent citation formatting)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Maternal embryonic leucine zipper kinase (MELK)''' is an [[enzyme]] that in humans is encoded by the ''MELK'' [[gene]].<ref name="pmid8724849">{{cite journal | vauthors = Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N | title = Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 | journal = DNA Research | volume = 3 | issue = 1 | pages = 17–24 | date = February 1996 | pmid = 8724849 | pmc =  | doi = 10.1093/dnares/3.1.17 }}</ref><ref name="pmid9136115">{{cite journal | vauthors = Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL | title = New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo | journal = Molecular Reproduction and Development | volume = 47 | issue = 2 | pages = 148–56 | date = June 1997 | pmid = 9136115 | pmc =  | doi = 10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MELK maternal embryonic leucine zipper kinase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9833| accessdate = }}</ref>  MELK is a [[Serine/threonine-specific protein kinase|serine/threonine kinase]] belonging to the family of AMPK/snf1 protein kinases.  MELK was first identified present as maternal mRNA in mouse embryos.<ref>{{cite journal | vauthors = Heyer BS, Kochanowski H, Solter D | title = Expression of Melk, a new protein kinase, during early mouse development | journal = Developmental Dynamics | volume = 215 | issue = 4 | pages = 344–51 | date = August 1999 | pmid = 10417823 | doi = 10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H  }}</ref>  MELK has been shown to involved in progression through the cell cycle, possibly linked to its interaction with CDC25B.<ref>{{cite journal | vauthors = Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI | title = Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation | journal = The Journal of Cell Biology | volume = 170 | issue = 3 | pages = 413–27 | date = August 2005 | pmid = 16061694 | pmc = 2171475 | doi = 10.1083/jcb.200412115  }}</ref>  MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.<ref>{{cite journal | vauthors = Gray D, Jubb AM, Hogue D, Dowd P, Kljavin N, Yi S, Bai W, Frantz G, Zhang Z, Koeppen H, de Sauvage FJ, Davis DP | title = Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers | journal = Cancer Research | volume = 65 | issue = 21 | pages = 9751–61 | date = November 2005 | pmid = 16266996 | doi = 10.1158/0008-5472.CAN-04-4531  }}</ref> 
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Maternal embryonic leucine zipper kinase
| HGNCid = 16870
| Symbol = MELK
| AltSymbols =; HPK38; KIAA0175
| OMIM = 607025
| ECnumber = 
| Homologene = 32111
| MGIid = 106924
| GeneAtlas_image1 = PBB_GE_MELK_204825_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9833
    | Hs_Ensembl = ENSG00000165304
    | Hs_RefseqProtein = NP_055606
    | Hs_RefseqmRNA = NM_014791
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 36562873
    | Hs_GenLoc_end = 36667678
    | Hs_Uniprot = Q14680
    | Mm_EntrezGene = 17279
    | Mm_Ensembl = ENSMUSG00000035683
    | Mm_RefseqmRNA = NM_010790
    | Mm_RefseqProtein = NP_034920
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 44321976
    | Mm_GenLoc_end = 44385775
    | Mm_Uniprot = Q3TJF3
  }}
}}
'''Maternal embryonic leucine zipper kinase''', also known as '''MELK''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MELK maternal embryonic leucine zipper kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9833| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
MELK has been shown to [[Protein-protein interaction|interact]] with [[CDC25B]].<ref name=pmid12400006>{{cite journal | vauthors = Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP | title = Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation | journal = Oncogene | volume = 21 | issue = 50 | pages = 7630–41 | date = October 2002 | pmid = 12400006 | doi = 10.1038/sj.onc.1205870 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lin ML, Park JH, Nishidate T, Nakamura Y, Katagiri T | title = Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family | journal = Breast Cancer Research | volume = 9 | issue = 1 | pages = R17 | year = 2007 | pmid = 17280616 | pmc = 1851384 | doi = 10.1186/bcr1650 }}
| citations =
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Lin ML, Park JH, Nishidate T, ''et al.'' |title=Involvement of maternal embryonic leucine zipper kinase (MELK) in mammary carcinogenesis through interaction with Bcl-G, a pro-apoptotic member of the Bcl-2 family. |journal=Breast Cancer Res. |volume=9 |issue= 1 |pages= R17 |year= 2007 |pmid= 17280616 |doi= 10.1186/bcr1650 }}
* {{cite journal | vauthors = Beullens M, Vancauwenbergh S, Morrice N, Derua R, Ceulemans H, Waelkens E, Bollen M | title = Substrate specificity and activity regulation of protein kinase MELK | journal = The Journal of Biological Chemistry | volume = 280 | issue = 48 | pages = 40003–11 | date = December 2005 | pmid = 16216881 | doi = 10.1074/jbc.M507274200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
* {{cite journal | vauthors = Vulsteke V, Beullens M, Boudrez A, Keppens S, Van Eynde A, Rider MH, Stalmans W, Bollen M | title = Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 10 | pages = 8642–7 | date = March 2004 | pmid = 14699119 | doi = 10.1074/jbc.M311466200 }}
*{{cite journal | author=Beullens M, Vancauwenbergh S, Morrice N, ''et al.'' |title=Substrate specificity and activity regulation of protein kinase MELK. |journal=J. Biol. Chem. |volume=280 |issue= 48 |pages= 40003-11 |year= 2006 |pmid= 16216881 |doi= 10.1074/jbc.M507274200 }}
* {{cite journal | vauthors = Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP | title = Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation | journal = Oncogene | volume = 21 | issue = 50 | pages = 7630–41 | date = October 2002 | pmid = 12400006 | doi = 10.1038/sj.onc.1205870 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Seong HA, Gil M, Kim KT, Kim SJ, Ha H | title = Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38) | journal = The Biochemical Journal | volume = 361 | issue = Pt 3 | pages = 597–604 | date = February 2002 | pmid = 11802789 | pmc = 1222342 | doi = 10.1042/0264-6021:3610597 }}
*{{cite journal  | author=Vulsteke V, Beullens M, Boudrez A, ''et al.'' |title=Inhibition of spliceosome assembly by the cell cycle-regulated protein kinase MELK and involvement of splicing factor NIPP1. |journal=J. Biol. Chem. |volume=279 |issue= 10 |pages= 8642-7 |year= 2004 |pmid= 14699119 |doi= 10.1074/jbc.M311466200 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Gil M, Yang Y, Lee Y, Choi I, Ha H | title = Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells | journal = Gene | volume = 195 | issue = 2 | pages = 295–301 | date = August 1997 | pmid = 9305775 | doi = 10.1016/S0378-1119(97)00181-9 }}
*{{cite journal  | author=Davezac N, Baldin V, Blot J, ''et al.'' |title=Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation. |journal=Oncogene |volume=21 |issue= 50 |pages= 7630-41 |year= 2002 |pmid= 12400006 |doi= 10.1038/sj.onc.1205870 }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Seong HA, Gil M, Kim KT, ''et al.'' |title=Phosphorylation of a novel zinc-finger-like protein, ZPR9, by murine protein serine/threonine kinase 38 (MPK38). |journal=Biochem. J. |volume=361 |issue= Pt 3 |pages= 597-604 |year= 2002 |pmid= 11802789 |doi= }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal | author=Gil M, Yang Y, Lee Y, ''et al.'' |title=Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic cells. |journal=Gene |volume=195 |issue= 2 |pages= 295-301 |year= 1997 |pmid= 9305775 |doi=  }}
*{{cite journal  | author=Heyer BS, Warsowe J, Solter D, ''et al.'' |title=New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo. |journal=Mol. Reprod. Dev. |volume=47 |issue= 2 |pages= 148-56 |year= 1997 |pmid= 9136115 |doi= 10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M }}
*{{cite journal | author=Nagase T, Seki N, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=3 |issue= 1 |pages= 17-24 |year= 1996 |pmid= 8724849 |doi=  }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Serine/threonine-specific protein kinases}}
{{WikiDoc Sources}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
{{gene-9-stub}}
 
[[Category:EC 2.7.11]]

Revision as of 17:02, 27 November 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Maternal embryonic leucine zipper kinase (MELK) is an enzyme that in humans is encoded by the MELK gene.[1][2][3] MELK is a serine/threonine kinase belonging to the family of AMPK/snf1 protein kinases. MELK was first identified present as maternal mRNA in mouse embryos.[4] MELK has been shown to involved in progression through the cell cycle, possibly linked to its interaction with CDC25B.[5] MELK expression is elevated in a number of cancers and is an active research target for pharmacological inhibition.[6]

Interactions

MELK has been shown to interact with CDC25B.[7]

References

  1. ↑ Nagase T, Seki N, Ishikawa K, Tanaka A, Nomura N (February 1996). "Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1". DNA Research. 3 (1): 17–24. doi:10.1093/dnares/3.1.17. PMID 8724849.
  2. ↑ Heyer BS, Warsowe J, Solter D, Knowles BB, Ackerman SL (June 1997). "New member of the Snf1/AMPK kinase family, Melk, is expressed in the mouse egg and preimplantation embryo". Molecular Reproduction and Development. 47 (2): 148–56. doi:10.1002/(SICI)1098-2795(199706)47:2<148::AID-MRD4>3.0.CO;2-M. PMID 9136115.
  3. ↑ "Entrez Gene: MELK maternal embryonic leucine zipper kinase".
  4. ↑ Heyer BS, Kochanowski H, Solter D (August 1999). "Expression of Melk, a new protein kinase, during early mouse development". Developmental Dynamics. 215 (4): 344–51. doi:10.1002/(SICI)1097-0177(199908)215:43.0.CO;2-H. PMID 10417823.
  5. ↑ Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI (August 2005). "Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation". The Journal of Cell Biology. 170 (3): 413–27. doi:10.1083/jcb.200412115. PMC 2171475. PMID 16061694.
  6. ↑ Gray D, Jubb AM, Hogue D, Dowd P, Kljavin N, Yi S, Bai W, Frantz G, Zhang Z, Koeppen H, de Sauvage FJ, Davis DP (November 2005). "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers". Cancer Research. 65 (21): 9751–61. doi:10.1158/0008-5472.CAN-04-4531. PMID 16266996.
  7. ↑ Davezac N, Baldin V, Blot J, Ducommun B, Tassan JP (October 2002). "Human pEg3 kinase associates with and phosphorylates CDC25B phosphatase: a potential role for pEg3 in cell cycle regulation". Oncogene. 21 (50): 7630–41. doi:10.1038/sj.onc.1205870. PMID 12400006.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=MELK&oldid=1422656"