INSL4: Difference between revisions

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Latest revision as of 23:54, 31 August 2017

Early placenta insulin-like peptide is a protein that in humans is encoded by the INSL4 gene.^[1]^[2]^[3]

INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.^[3]

References

↑ Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (Aug 1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics. 29 (2): 465–70. doi:10.1006/geno.1995.9980. PMID 8666396.
↑ Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K (Oct 1998). "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet. 81 (3–4): 275–7. doi:10.1159/000015045. PMID 9730618.
↑ ^3.0 ^3.1 "Entrez Gene: INSL4 insulin-like 4 (placenta)".

Koman A, Cazaubon S, Couraud PO, et al. (1996). "Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family". J. Biol. Chem. 271 (34): 20238–41. doi:10.1074/jbc.271.34.20238. PMID 8702754.
Bellet D, Lavaissiere L, Mock P, et al. (1997). "Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta". J. Clin. Endocrinol. Metab. 82 (9): 3169–72. doi:10.1210/jc.82.9.3169. PMID 9284764.
Laurent A, Rouillac C, Delezoide AL, et al. (1999). "Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues". Mol. Reprod. Dev. 51 (2): 123–9. doi:10.1002/(SICI)1098-2795(199810)51:2<123::AID-MRD1>3.0.CO;2-S. PMID 9740319.
Janneau JL, Maldonado-Estrada J, Tachdjian G, et al. (2002). "Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells". J. Clin. Endocrinol. Metab. 87 (11): 5336–9. doi:10.1210/jc.2002-021093. PMID 12414911.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bièche I, Laurent A, Laurendeau I, et al. (2004). "Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element". Biol. Reprod. 68 (4): 1422–9. doi:10.1095/biolreprod.102.010322. PMID 12606452.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Millar L, Streiner N, Webster L, et al. (2006). "Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth". Biol. Reprod. 73 (4): 695–702. doi:10.1095/biolreprod.105.039859. PMC 1382170. PMID 15958731.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid8666396-1] Chassin D, Laurent A, Janneau JL, Berger R, Bellet D (Aug 1996). "Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta". Genomics. 29 (2): 465–70. doi:10.1006/geno.1995.9980. PMID 8666396.

[pmid9730618-2] Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K (Oct 1998). "The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome". Cytogenet Cell Genet. 81 (3–4): 275–7. doi:10.1159/000015045. PMID 9730618.

[entrez-3] 3.0 ^3.1 "Entrez Gene: INSL4 insulin-like 4 (placenta)".

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[2]

[3]

@@ Line 1: / Line 1: @@
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+'''Early placenta insulin-like peptide''' is a [[protein]] that in humans is encoded by the ''INSL4'' [[gene]].<ref name="pmid8666396">{{cite journal |vauthors=Chassin D, Laurent A, Janneau JL, Berger R, Bellet D | title = Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta | journal = Genomics | volume = 29 | issue = 2 | pages = 465–70 |date=Aug 1996 | pmid = 8666396 | pmc =  | doi = 10.1006/geno.1995.9980 }}</ref><ref name="pmid9730618">{{cite journal |vauthors=Veitia R, Laurent A, Quintana-Murci L, Ottolenghi C, Fellous M, Vidaud M, McElreavey K | title = The INSL4 gene maps close to WI-5527 at 9p24.1→p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome | journal = Cytogenet Cell Genet | volume = 81 | issue = 3–4 | pages = 275–7 |date=Oct 1998 | pmid = 9730618 | pmc =  | doi =10.1159/000015045  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: INSL4 insulin-like 4 (placenta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3641| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Insulin-like 4 (placenta)
- | HGNCid = 6087
- | Symbol = INSL4
- | AltSymbols =; EPIL; PLACENTIN
- | OMIM = 600910
- | ECnumber =
- | Homologene = 88662
- | MGIid =
-  | GeneAtlas_image1 = PBB_GE_INSL4_206549_at_tn.png
- | Function = {{GNF_GO|id=GO:0005159 |text = insulin-like growth factor receptor binding}} {{GNF_GO|id=GO:0005179 |text = hormone activity}}
- | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
- | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0007565 |text = female pregnancy}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
-  | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 3641
-    | Hs_Ensembl = ENSG00000120211
-    | Hs_RefseqProtein = NP_002186
-    | Hs_RefseqmRNA = NM_002195
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 9
-    | Hs_GenLoc_start = 5221419
-    | Hs_GenLoc_end = 5225304
-    | Hs_Uniprot = Q14641
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Insulin-like 4 (placenta)''', also known as '''INSL4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: INSL4 insulin-like 4 (placenta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3641| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
+{{PBB Summary
 | section_title =
-| summary_text = INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 polypeptide chains, A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early placental cytotrophoblast and syncytiotrophoblast.<ref name="entrez">{{cite web | title = Entrez Gene: INSL4 insulin-like 4 (placenta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3641| accessdate = }}</ref>
+| summary_text = INSL4 encodes the insulin-like 4 protein, a member of the insulin superfamily. INSL4 encodes a precursor that undergoes post-translational cleavage to produce 3 [[polypeptide chains]], A-C, that form tertiary structures composed of either all three chains, or just the A and B chains. Expression of INSL4 products occurs within the early [[placenta]]l [[cytotrophoblast]] and [[syncytiotrophoblast]].<ref name="entrez"/>
 }}
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+{{PBB Further reading
 | citations =
-*{{cite journal  | author=Chassin D, Laurent A, Janneau JL, ''et al.'' |title=Cloning of a new member of the insulin gene superfamily (INSL4) expressed in human placenta. |journal=Genomics |volume=29 |issue= 2 |pages= 465-70 |year= 1996 |pmid= 8666396 |doi= 10.1006/geno.1995.9980 }}
+*{{cite journal   |vauthors=Koman A, Cazaubon S, Couraud PO, etal |title=Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20238–41 |year= 1996 |pmid= 8702754 |doi=10.1074/jbc.271.34.20238  }}
-*{{cite journal  | author=Koman A, Cazaubon S, Couraud PO, ''et al.'' |title=Molecular characterization and in vitro biological activity of placentin, a new member of the insulin gene family. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20238-41 |year= 1996 |pmid= 8702754 |doi=  }}
+*{{cite journal   |vauthors=Bellet D, Lavaissiere L, Mock P, etal |title=Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 9 |pages= 3169–72 |year= 1997 |pmid= 9284764 |doi=10.1210/jc.82.9.3169  }}
-*{{cite journal  | author=Bellet D, Lavaissiere L, Mock P, ''et al.'' |title=Identification of pro-EPIL and EPIL peptides translated from insulin-like 4 (INSL4) mRNA in human placenta. |journal=J. Clin. Endocrinol. Metab. |volume=82 |issue= 9 |pages= 3169-72 |year= 1997 |pmid= 9284764 |doi=  }}
+*{{cite journal   |vauthors=Laurent A, Rouillac C, Delezoide AL, etal |title=Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues |journal=Mol. Reprod. Dev. |volume=51 |issue= 2 |pages= 123–9 |year= 1999 |pmid= 9740319 |doi= 10.1002/(SICI)1098-2795(199810)51:2<123::AID-MRD1>3.0.CO;2-S }}
-*{{cite journal  | author=Veitia R, Laurent A, Quintana-Murci L, ''et al.'' |title=The INSL4 gene maps close to WI-5527 at 9p24.1-->p23.3 clustered with two relaxin genes and outside the critical region for the monosomy 9p syndrome. |journal=Cytogenet. Cell Genet. |volume=81 |issue= 3-4 |pages= 275-7 |year= 1998 |pmid= 9730618 |doi=  }}
+*{{cite journal   |vauthors=Janneau JL, Maldonado-Estrada J, Tachdjian G, etal |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336–9 |year= 2002 |pmid= 12414911 |doi=10.1210/jc.2002-021093  }}
-*{{cite journal  | author=Laurent A, Rouillac C, Delezoide AL, ''et al.'' |title=Insulin-like 4 (INSL4) gene expression in human embryonic and trophoblastic tissues. |journal=Mol. Reprod. Dev. |volume=51 |issue= 2 |pages= 123-9 |year= 1999 |pmid= 9740319 |doi= 10.1002/(SICI)1098-2795(199810)51:2<123::AID-MRD1>3.0.CO;2-S }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Janneau JL, Maldonado-Estrada J, Tachdjian G, ''et al.'' |title=Transcriptional expression of genes involved in cell invasion and migration by normal and tumoral trophoblast cells. |journal=J. Clin. Endocrinol. Metab. |volume=87 |issue= 11 |pages= 5336-9 |year= 2002 |pmid= 12414911 |doi=  }}
+*{{cite journal   |vauthors=Bièche I, Laurent A, Laurendeau I, etal |title=Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element |journal=Biol. Reprod. |volume=68 |issue= 4 |pages= 1422–9 |year= 2004 |pmid= 12606452 |doi= 10.1095/biolreprod.102.010322 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Humphray SJ, Oliver K, Hunt AR, etal |title=DNA sequence and analysis of human chromosome 9 |journal=Nature |volume=429 |issue= 6990 |pages= 369–74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465  | pmc=2734081 }}
-*{{cite journal  | author=Bièche I, Laurent A, Laurendeau I, ''et al.'' |title=Placenta-specific INSL4 expression is mediated by a human endogenous retrovirus element. |journal=Biol. Reprod. |volume=68 |issue= 4 |pages= 1422-9 |year= 2004 |pmid= 12606452 |doi= 10.1095/biolreprod.102.010322 }}
+*{{cite journal  |vauthors=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504  | pmc=2286551 }}
-*{{cite journal  | author=Humphray SJ, Oliver K, Hunt AR, ''et al.'' |title=DNA sequence and analysis of human chromosome 9. |journal=Nature |volume=429 |issue= 6990 |pages= 369-74 |year= 2004 |pmid= 15164053 |doi= 10.1038/nature02465 }}
+*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
-*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
+*{{cite journal   |vauthors=Millar L, Streiner N, Webster L, etal |title=Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth |journal=Biol. Reprod. |volume=73 |issue= 4 |pages= 695–702 |year= 2006 |pmid= 15958731 |doi= 10.1095/biolreprod.105.039859  | pmc=1382170 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
-*{{cite journal  | author=Millar L, Streiner N, Webster L, ''et al.'' |title=Early placental insulin-like protein (INSL4 or EPIL) in placental and fetal membrane growth. |journal=Biol. Reprod. |volume=73 |issue= 4 |pages= 695-702 |year= 2006 |pmid= 15958731 |doi= 10.1095/biolreprod.105.039859 }}
 }}
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INSL4: Difference between revisions

Latest revision as of 23:54, 31 August 2017

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