Atopic dermatitis natural history, complications and prognosis: Difference between revisions
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{{Atopic dermatitis}} | {{Atopic dermatitis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{S.S}} | ||
==Overview== | ==Overview== | ||
Revision as of 14:47, 9 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shalinder Singh, M.B.B.S.[2]
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of atopic dermatitis usually starts during the first years of life, and presents with symptoms such as intense pruritus and chronic and relapsing age dependent eczematous lesions.[1]
- Majority of the infants and children with atopic dermatitis, usually grow out of the disease during childhood.[2]
- In severe cases, atopic dermatitis continue or relapses in adulthood.[3]
- Natural history of atopic dermatitis can be categorized into various subtypes according to the clinical features.
- The most common subtype was characterized by the early onset of atopic dermatitis (<2 years) and persistent until adulthood.[4]
- In the sequence of atopy march diseases, atopic dermatits is the first to commence during infancy, followed by allergic rhinits, food allergy and asthma later in life.[5]
- Atopic dermatitis is a life long disease with periods of waxing and waning eczematous skin lesions.[6]
Complications
- Common complications of atopic dermatitis include:
- Super-infection
- Staphylococcus aureus[7]
- Herpes simplex virus ( Kaposi varicelliform eruption or eczema herpeticum) - occurs in <3% of patients
- Molluscum contagiosum
- Sleep problems due to intense pruritus
- Ocular comorbidities
- Topical corticosteroids can leasd to striae
- Atopy march: other atopic disorders such as allergic rhinitis food allergy and asthma
- Super-infection
Prognosis
- Atopic dermatitis is chronic disease with varying subtypes.[10]
- The presence of severe atopic dermatitis and early atopic sensitization is associated with a particularly poor prognosis.[11]
- Mortality is unusual in atopic dermatitis.
References
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Burr ML, Dunstan FD, Hand S, Ingram JR, Jones KP (June 2013). "The natural history of eczema from birth to adult life: a cohort study". Br. J. Dermatol. 168 (6): 1339–42. doi:10.1111/bjd.12216. PMID 23301666.
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Spergel JM (August 2010). "From atopic dermatitis to asthma: the atopic march". Ann. Allergy Asthma Immunol. 105 (2): 99–106, quiz 107–9, 117. doi:10.1016/j.anai.2009.10.002. PMID 20674819.
- ↑ Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ (June 2014). "Persistence of mild to moderate atopic dermatitis". JAMA Dermatol. 150 (6): 593–600. doi:10.1001/jamadermatol.2013.10271. PMC 4352328. PMID 24696036.
- ↑ Matiz C, Tom WL, Eichenfield LF, Pong A, Friedlander SF (2011). "Children with atopic dermatitis appear less likely to be infected with community acquired methicillin-resistant Staphylococcus aureus: the San Diego experience". Pediatr Dermatol. 28 (1): 6–11. doi:10.1111/j.1525-1470.2010.01293.x. PMID 21070347.
- ↑ Chen JJ, Applebaum DS, Sun GS, Pflugfelder SC (March 2014). "Atopic keratoconjunctivitis: A review". J. Am. Acad. Dermatol. 70 (3): 569–75. doi:10.1016/j.jaad.2013.10.036. PMID 24342754.
- ↑ Pattnaik L, Acharya L (May 2015). "A comprehensive review on vernal keratoconjunctivitis with emphasis on proteomics". Life Sci. 128: 47–54. doi:10.1016/j.lfs.2015.01.040. PMID 25744396.
- ↑ Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U (May 2004). "The natural course of atopic dermatitis from birth to age 7 years and the association with asthma". J. Allergy Clin. Immunol. 113 (5): 925–31. doi:10.1016/j.jaci.2004.01.778. PMID 15131576.
- ↑ Illi S, von Mutius E, Lau S, Nickel R, Grüber C, Niggemann B, Wahn U (May 2004). "The natural course of atopic dermatitis from birth to age 7 years and the association with asthma". J. Allergy Clin. Immunol. 113 (5): 925–31. doi:10.1016/j.jaci.2004.01.778. PMID 15131576.