VRK1: Difference between revisions

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{{Underlinked|date=June 2016}}
{{Underlinked|date=June 2016}}
{{Infobox_gene}}
{{Infobox_gene}}
[[File:Crystal Structure of the Human vaccinia-related kinase.png|thumb|Crystal Structure of the Human vaccinia-related kinase.png|thumb|Cartoon diagram of the Human vaccinia-related kinase protein PDB entry {{PDBe|6bru}}]]
'''Serine/threonine-protein kinase VRK1''' is an [[enzyme]] that in humans is encoded by the ''VRK1'' [[gene]].<ref name="pmid9344656">{{cite journal | vauthors = Nezu J, Oku A, Jones MH, Shimane M | title = Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase | journal = Genomics | volume = 45 | issue = 2 | pages = 327–31 |date=Feb 1998 | pmid = 9344656 | pmc =  | doi =10.1006/geno.1997.4938  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VRK1 vaccinia related kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7443| accessdate = }}</ref>
'''Serine/threonine-protein kinase VRK1''' is an [[enzyme]] that in humans is encoded by the ''VRK1'' [[gene]].<ref name="pmid9344656">{{cite journal | vauthors = Nezu J, Oku A, Jones MH, Shimane M | title = Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase | journal = Genomics | volume = 45 | issue = 2 | pages = 327–31 |date=Feb 1998 | pmid = 9344656 | pmc =  | doi =10.1006/geno.1997.4938  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VRK1 vaccinia related kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7443| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
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| summary_text = This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.<ref name="entrez">{{cite web | title = Entrez Gene: VRK1 vaccinia related kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7443| accessdate = }}</ref>
| summary_text = This [[gene]] encodes a member of the vaccinia-related kinase (VRK) family of [[Serine/threonine protein kinase|serine/threonine protein kinases]]. This gene is widely expressed in human [[Tissue (biology)|tissues]] and has increased expression in actively [[Cell division|dividing cells]], such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the [[Cell nucleus|nucleus]] and has been shown to promote the stability and nuclear accumulation of a transcriptionally active [[p53]] molecule and, ''in vitro'', to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate [[Cell growth|cell proliferation]]. This protein also phosphorylates histone, casein, and the transcription factors [[Activating transcription factor 2|ATF2]] (activating transcription factor 2) and [[C-jun]].<ref name="entrez">{{cite web | title = Entrez Gene: VRK1 vaccinia related kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7443| accessdate = }}</ref>
}}
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Revision as of 22:01, 3 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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Wikidata
View/Edit Human
File:Crystal Structure of the Human vaccinia-related kinase.png
Cartoon diagram of the Human vaccinia-related kinase protein PDB entry 6bru

Serine/threonine-protein kinase VRK1 is an enzyme that in humans is encoded by the VRK1 gene.[1][2]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and C-jun.[2]

References

  1. ↑ Nezu J, Oku A, Jones MH, Shimane M (Feb 1998). "Identification of two novel human putative serine/threonine kinases, VRK1 and VRK2, with structural similarity to vaccinia virus B1R kinase". Genomics. 45 (2): 327–31. doi:10.1006/geno.1997.4938. PMID 9344656.
  2. ↑ 2.0 2.1 "Entrez Gene: VRK1 vaccinia related kinase 1".

Further reading



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