CCL1: Difference between revisions
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'''Chemokine (C-C motif) ligand 1''' (CCL1) is a small [[glycoprotein]] secreted by activated [[T cell]]s that belongs to a family inflammatory cytokines known as [[chemokine]]s.<ref>{{cite journal |doi=10.1073/pnas.89.7.2950 |vauthors=Miller MD, Krangel MS |title=The human cytokine I-309 is a monocyte chemoattractant |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue=7 |pages=2950–4 |date=April 1992 |pmid=1557400 |pmc=48781 }}</ref> CCL1 attracts [[monocyte]]s, [[NK cell]]s, and immature [[B cell]]s and [[dendritic cell]]s by interacting with a cell surface [[chemokine receptor]] called [[CC chemokine receptors#CCR8|CCR8]].<ref>{{cite journal |doi=10.1074/jbc.272.28.17251 |vauthors=Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B |title=Identification of CCR8, the receptor for the human CC chemokine I-309 |journal=J. Biol. Chem. |volume=272 |issue=28 |pages=17251–4 |date=July 1997 |pmid=9211859 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9211859}}</ref> This chemokine resides in a large cluster of CC chemokines on human [[chromosome 17]]. | '''Chemokine (C-C motif) ligand 1''' (CCL1) is a small [[glycoprotein]] secreted by activated [[T cell]]s that belongs to a family of inflammatory cytokines known as [[chemokine]]s.<ref>{{cite journal |doi=10.1073/pnas.89.7.2950 |vauthors=Miller MD, Krangel MS |title=The human cytokine I-309 is a monocyte chemoattractant |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue=7 |pages=2950–4 |date=April 1992 |pmid=1557400 |pmc=48781 }}</ref> CCL1 attracts [[monocyte]]s, [[NK cell]]s, and immature [[B cell]]s and [[dendritic cell]]s by interacting with a cell surface [[chemokine receptor]] called [[CC chemokine receptors#CCR8|CCR8]].<ref>{{cite journal |doi=10.1074/jbc.272.28.17251 |vauthors=Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B |title=Identification of CCR8, the receptor for the human CC chemokine I-309 |journal=J. Biol. Chem. |volume=272 |issue=28 |pages=17251–4 |date=July 1997 |pmid=9211859 |url=http://www.jbc.org/cgi/pmidlookup?view=long&pmid=9211859}}</ref> This chemokine resides in a large cluster of CC chemokines on human [[chromosome 17]]. | ||
==References== | ==References== | ||
Latest revision as of 14:29, 11 April 2018
| chemokine (C-C motif) ligand 1 | |
|---|---|
| Identifiers | |
| Symbol | CCL1 |
| Alt. symbols | SCYA1, I-309, TCA3, P500, SISe |
| Entrez | 6346 |
| HUGO | 10609 |
| OMIM | 182281 |
| PDB | 1EL0 |
| RefSeq | NM_002981 |
| UniProt | P22362 |
| Other data | |
| Locus | Chr. 17 q11.2 |
Chemokine (C-C motif) ligand 1 (CCL1) is a small glycoprotein secreted by activated T cells that belongs to a family of inflammatory cytokines known as chemokines.[1] CCL1 attracts monocytes, NK cells, and immature B cells and dendritic cells by interacting with a cell surface chemokine receptor called CCR8.[2] This chemokine resides in a large cluster of CC chemokines on human chromosome 17.
References
- ↑ Miller MD, Krangel MS (April 1992). "The human cytokine I-309 is a monocyte chemoattractant". Proc. Natl. Acad. Sci. U.S.A. 89 (7): 2950–4. doi:10.1073/pnas.89.7.2950. PMC 48781. PMID 1557400.
- ↑ Roos RS, Loetscher M, Legler DF, Clark-Lewis I, Baggiolini M, Moser B (July 1997). "Identification of CCR8, the receptor for the human CC chemokine I-309". J. Biol. Chem. 272 (28): 17251–4. doi:10.1074/jbc.272.28.17251. PMID 9211859.
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