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{{Infobox_gene}}
{{Infobox_gene}}
CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2)  for ubiquitin mediated degradation.
CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2)  for ubiquitin mediated degradation.
'''Ubiquitin-conjugating enzyme E2 R1''' is a [[protein]] that in humans is encoded by the ''CDC34'' [[gene]].<ref name="pmid8248134">{{cite journal | vauthors = Plon SE, Leppig KA, Do HN, Groudine M | title = Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 22 | pages = 10484–8 |date=Dec 1993 | pmid = 8248134 | pmc = 47801 | doi =10.1073/pnas.90.22.10484  }}</ref><ref name="pmid16210246">{{cite journal | vauthors = Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ | title = Proximity-induced activation of human Cdc34 through heterologous dimerization | journal = Proc Natl Acad Sci U S A | volume = 102 | issue = 42 | pages = 15053–8 |date=Oct 2005 | pmid = 16210246 | pmc = 1242854 | doi = 10.1073/pnas.0507646102 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=997| accessdate = }}</ref>
'''Ubiquitin-conjugating enzyme E2 R1''' is a [[protein]] that in humans is encoded by the ''CDC34'' [[gene]].<ref name="pmid8248134">{{cite journal | vauthors = Plon SE, Leppig KA, Do HN, Groudine M | title = Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast | journal = Proc Natl Acad Sci U S A | volume = 90 | issue = 22 | pages = 10484–8 |date=Dec 1993 | pmid = 8248134 | pmc = 47801 | doi =10.1073/pnas.90.22.10484  | bibcode = 1993PNAS...9010484P }}</ref><ref name="pmid16210246">{{cite journal | vauthors = Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ | title = Proximity-induced activation of human Cdc34 through heterologous dimerization | journal = Proc Natl Acad Sci U S A | volume = 102 | issue = 42 | pages = 15053–8 |date=Oct 2005 | pmid = 16210246 | pmc = 1242854 | doi = 10.1073/pnas.0507646102 | bibcode = 2005PNAS..10215053G }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=997| accessdate = }}</ref>


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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | vauthors=King RW, Deshaies RJ, Peters JM, Kirschner MW |title=How proteolysis drives the cell cycle. |journal=Science |volume=274 |issue= 5293 |pages= 1652–9 |year= 1997 |pmid= 8939846 |doi=10.1126/science.274.5293.1652  }}
*{{cite journal  | vauthors=King RW, Deshaies RJ, Peters JM, Kirschner MW |title=How proteolysis drives the cell cycle. |journal=Science |volume=274 |issue= 5293 |pages= 1652–9 |year= 1997 |pmid= 8939846 |doi=10.1126/science.274.5293.1652  |bibcode=1996Sci...274.1652K }}
*{{cite journal  | author=Pagano M |title=Cell cycle regulation by the ubiquitin pathway. |journal=FASEB J. |volume=11 |issue= 13 |pages= 1067–75 |year= 1997 |pmid= 9367342 |doi=  }}
*{{cite journal  | author=Pagano M |title=Cell cycle regulation by the ubiquitin pathway. |journal=FASEB J. |volume=11 |issue= 13 |pages= 1067–75 |year= 1997 |pmid= 9367342 |doi=  }}
*{{cite journal  | vauthors=Lisztwan J, Marti A, Sutterlüty H |title=Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. |journal=EMBO J. |volume=17 |issue= 2 |pages= 368–83 |year= 1998 |pmid= 9430629 |doi= 10.1093/emboj/17.2.368  | pmc=1170388 |display-authors=etal}}
*{{cite journal  | vauthors=Lisztwan J, Marti A, Sutterlüty H |title=Association of human CUL-1 and ubiquitin-conjugating enzyme CDC34 with the F-box protein p45(SKP2): evidence for evolutionary conservation in the subunit composition of the CDC34-SCF pathway. |journal=EMBO J. |volume=17 |issue= 2 |pages= 368–83 |year= 1998 |pmid= 9430629 |doi= 10.1093/emboj/17.2.368  | pmc=1170388 |display-authors=etal}}
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*{{cite journal  | vauthors=Kiernan RE, Emiliani S, Nakayama K |title=Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 7956–70 |year= 2001 |pmid= 11689688 |doi= 10.1128/MCB.21.23.7956-7970.2001  | pmc=99964 |display-authors=etal}}
*{{cite journal  | vauthors=Kiernan RE, Emiliani S, Nakayama K |title=Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome. |journal=Mol. Cell. Biol. |volume=21 |issue= 23 |pages= 7956–70 |year= 2001 |pmid= 11689688 |doi= 10.1128/MCB.21.23.7956-7970.2001  | pmc=99964 |display-authors=etal}}
*{{cite journal  | vauthors=Semplici F, Meggio F, Pinna LA, Oliviero S |title=CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. |journal=Oncogene |volume=21 |issue= 25 |pages= 3978–87 |year= 2002 |pmid= 12037680 |doi= 10.1038/sj.onc.1205574 }}
*{{cite journal  | vauthors=Semplici F, Meggio F, Pinna LA, Oliviero S |title=CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation. |journal=Oncogene |volume=21 |issue= 25 |pages= 3978–87 |year= 2002 |pmid= 12037680 |doi= 10.1038/sj.onc.1205574 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal|bibcode=2002PNAS...9916899M }}
}}
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Latest revision as of 01:08, 23 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

CDC34 is a gene encoding a protein product that has ubiquitin conjugating activity. CDC34 was originally discovered by work in baker's yeast as a gene that has a role in the cell division cycle. Cdc34 in yeast targets numerous substrates (Sic1, Far1, Cln1, Cln2) for ubiquitin mediated degradation. Ubiquitin-conjugating enzyme E2 R1 is a protein that in humans is encoded by the CDC34 gene.[1][2][3]

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.[3]

Interactions

CDC34 has been shown to interact with CSNK2B,[4] BTRC[5][6] and CDK9.[7]

References

  1. ↑ Plon SE, Leppig KA, Do HN, Groudine M (Dec 1993). "Cloning of the human homolog of the CDC34 cell cycle gene by complementation in yeast". Proc Natl Acad Sci U S A. 90 (22): 10484–8. Bibcode:1993PNAS...9010484P. doi:10.1073/pnas.90.22.10484. PMC 47801. PMID 8248134.
  2. ↑ Gazdoiu S, Yamoah K, Wu K, Escalante CR, Tappin I, Bermudez V, Aggarwal AK, Hurwitz J, Pan ZQ (Oct 2005). "Proximity-induced activation of human Cdc34 through heterologous dimerization". Proc Natl Acad Sci U S A. 102 (42): 15053–8. Bibcode:2005PNAS..10215053G. doi:10.1073/pnas.0507646102. PMC 1242854. PMID 16210246.
  3. ↑ 3.0 3.1 "Entrez Gene: CDC34 cell division cycle 34 homolog (S. cerevisiae)".
  4. ↑ Block, K; Boyer T G; Yew P R (Nov 2001). "Phosphorylation of the human ubiquitin-conjugating enzyme, CDC34, by casein kinase 2". J. Biol. Chem. United States. 276 (44): 41049–58. doi:10.1074/jbc.M106453200. ISSN 0021-9258. PMID 11546811.
  5. ↑ Semplici, Francesca; Meggio Flavio; Pinna Lorenzo A; Oliviero Salvatore (Jun 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene. England. 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. ISSN 0950-9232. PMID 12037680.
  6. ↑ Cenciarelli, C; Chiaur D S; Guardavaccaro D; Parks W; Vidal M; Pagano M (Oct 1999). "Identification of a family of human F-box proteins". Curr. Biol. ENGLAND. 9 (20): 1177–9. doi:10.1016/S0960-9822(00)80020-2. ISSN 0960-9822. PMID 10531035.
  7. ↑ Kiernan, R E; Emiliani S; Nakayama K; Castro A; Labbé J C; Lorca T; Nakayama Ki K; Benkirane M (Dec 2001). "Interaction between cyclin T1 and SCF(SKP2) targets CDK9 for ubiquitination and degradation by the proteasome". Mol. Cell. Biol. United States. 21 (23): 7956–70. doi:10.1128/MCB.21.23.7956-7970.2001. ISSN 0270-7306. PMC 99964. PMID 11689688.

External links

Further reading



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