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==Interactions==
==Interactions==
Actinin alpha 4 has been shown to [[Protein-protein interaction|interact]] with [[PDLIM1]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=Oct 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10753915>{{cite journal |doi=10.1074/jbc.275.15.11100 |last=Vallenius |first=T |author2=Luukko K|author3=Mäkelä T P |date=Apr 2000 |title=CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4 |journal=J. Biol. Chem. |volume=275 |issue=15 |pages=11100–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10753915 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Sodium-hydrogen exchange regulatory cofactor 2]],<ref name=pmid11948184>{{cite journal |last=Kim |first=Jae Ho |author2=Lee-Kwon Whaseon |author3=Park Jong Bae |author4=Ryu Sung Ho|author5=Yun C H Chris |author6=Donowitz Mark |date=Jun 2002 |title=Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis |journal=J. Biol. Chem. |volume=277 |issue=26 |pages=23714–24 |publisher= |location = United States| issn = 0021-9258| pmid = 11948184 |doi = 10.1074/jbc.M200835200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Collagen, type XVII, alpha 1]],<ref name=pmid11739652>{{cite journal |last=Gonzalez |first=A M |author2=Otey C|author3=Edlund M|author4=Jones J C |date=Dec 2001 |title=Interactions of a hemidesmosome component and actinin family members |journal=J. Cell Sci. |volume=114 |issue=Pt 23 |pages=4197–206 |publisher= |location = England| issn = 0021-9533| pmid = 11739652 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CAMK2A]],<ref name=pmid11160423>{{cite journal |last=Walikonis |first=R S |author2=Oguni A |author3=Khorosheva E M |author4=Jeng C J |author5=Asuncion F J |author6=Kennedy M B  |date=Jan 2001 |title=Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin |journal=J. Neurosci. |volume=21 |issue=2 |pages=423–33 |publisher= |location = United States| issn = | pmid = 11160423 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CAMK2B]],<ref name=pmid11160423/> [[MAGI1]]<ref name=pmid12042308>{{cite journal |last=Patrie |first=Kevin M |author2=Drescher Andrew J|author3=Welihinda Ajith|author4=Mundel Peter|author5= Margolis Ben |date=Aug 2002 |title=Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 |journal=J. Biol. Chem. |volume=277 |issue=33 |pages=30183–90 |publisher= |location = United States| issn = 0021-9258| pmid = 12042308 |doi = 10.1074/jbc.M203072200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRIM3]].<ref name=pmid10673389>{{cite journal |last=El-Husseini |first=A E |author2=Kwasnicka D |author3=Yamada T |author4=Hirohashi S |author5=Vincent S R  |date=Jan 2000 |title=BERP, a novel ring finger protein, binds to alpha-actinin-4 |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue=3 |pages=906–11 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 10673389 |doi = 10.1006/bbrc.1999.2045 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
Actinin alpha 4 has been shown to [[Protein-protein interaction|interact]] with [[PDLIM1]],<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |author2=Venkatesan Kavitha |author3=Hao Tong |author4=Hirozane-Kishikawa Tomoko |author5=Dricot Amélie |author6=Li Ning |author7=Berriz Gabriel F |author8=Gibbons Francis D |author9=Dreze Matija |author10=Ayivi-Guedehoussou Nono |author11=Klitgord Niels |author12=Simon Christophe |author13=Boxem Mike |author14=Milstein Stuart |author15=Rosenberg Jennifer |author16=Goldberg Debra S |author17=Zhang Lan V |author18=Wong Sharyl L |author19=Franklin Giovanni |author20=Li Siming |author21=Albala Joanna S |author22=Lim Janghoo |author23=Fraughton Carlene |author24=Llamosas Estelle |author25=Cevik Sebiha |author26=Bex Camille |author27=Lamesch Philippe |author28=Sikorski Robert S |author29=Vandenhaute Jean |author30=Zoghbi Huda Y |author31=Smolyar Alex |author32=Bosak Stephanie |author33=Sequerra Reynaldo |author34=Doucette-Stamm Lynn |author35=Cusick Michael E |author36=Hill David E |author37=Roth Frederick P |author38=Vidal Marc |date=Oct 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode =2005Natur.437.1173R | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid10753915>{{cite journal |doi=10.1074/jbc.275.15.11100 |last=Vallenius |first=T |author2=Luukko K|author3=Mäkelä T P |date=Apr 2000 |title=CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4 |journal=J. Biol. Chem. |volume=275 |issue=15 |pages=11100–5 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10753915 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Sodium-hydrogen exchange regulatory cofactor 2]],<ref name=pmid11948184>{{cite journal |last=Kim |first=Jae Ho |author2=Lee-Kwon Whaseon |author3=Park Jong Bae |author4=Ryu Sung Ho|author5=Yun C H Chris |author6=Donowitz Mark |date=Jun 2002 |title=Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis |journal=J. Biol. Chem. |volume=277 |issue=26 |pages=23714–24 |publisher= |location = United States| issn = 0021-9258| pmid = 11948184 |doi = 10.1074/jbc.M200835200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Collagen, type XVII, alpha 1]],<ref name=pmid11739652>{{cite journal |last=Gonzalez |first=A M |author2=Otey C|author3=Edlund M|author4=Jones J C |date=Dec 2001 |title=Interactions of a hemidesmosome component and actinin family members |journal=J. Cell Sci. |volume=114 |issue=Pt 23 |pages=4197–206 |publisher= |location = England| issn = 0021-9533| pmid = 11739652 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CAMK2A]],<ref name=pmid11160423>{{cite journal |last=Walikonis |first=R S |author2=Oguni A |author3=Khorosheva E M |author4=Jeng C J |author5=Asuncion F J |author6=Kennedy M B  |date=Jan 2001 |title=Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin |journal=J. Neurosci. |volume=21 |issue=2 |pages=423–33 |publisher= |location = United States| issn = | pmid = 11160423 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[CAMK2B]],<ref name=pmid11160423/> [[MAGI1]]<ref name=pmid12042308>{{cite journal |last=Patrie |first=Kevin M |author2=Drescher Andrew J|author3=Welihinda Ajith|author4=Mundel Peter|author5= Margolis Ben |date=Aug 2002 |title=Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1 |journal=J. Biol. Chem. |volume=277 |issue=33 |pages=30183–90 |publisher= |location = United States| issn = 0021-9258| pmid = 12042308 |doi = 10.1074/jbc.M203072200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[TRIM3]].<ref name=pmid10673389>{{cite journal |last=El-Husseini |first=A E |author2=Kwasnicka D |author3=Yamada T |author4=Hirohashi S |author5=Vincent S R  |date=Jan 2000 |title=BERP, a novel ring finger protein, binds to alpha-actinin-4 |journal=Biochem. Biophys. Res. Commun. |volume=267 |issue=3 |pages=906–11 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 10673389 |doi = 10.1006/bbrc.1999.2045 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>


==See also==
==See also==

Latest revision as of 17:08, 22 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Alpha-actinin-4 is a protein that in humans is encoded by the ACTN4 gene.[1]

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis.[1]

Interactions

Actinin alpha 4 has been shown to interact with PDLIM1,[2][3] Sodium-hydrogen exchange regulatory cofactor 2,[4] Collagen, type XVII, alpha 1,[5] CAMK2A,[6] CAMK2B,[6] MAGI1[7] and TRIM3.[8]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: ACTN4 actinin, alpha 4".
  2. ↑ Rual, Jean-François; Venkatesan Kavitha; Hao Tong; Hirozane-Kishikawa Tomoko; Dricot Amélie; Li Ning; Berriz Gabriel F; Gibbons Francis D; Dreze Matija; Ayivi-Guedehoussou Nono; Klitgord Niels; Simon Christophe; Boxem Mike; Milstein Stuart; Rosenberg Jennifer; Goldberg Debra S; Zhang Lan V; Wong Sharyl L; Franklin Giovanni; Li Siming; Albala Joanna S; Lim Janghoo; Fraughton Carlene; Llamosas Estelle; Cevik Sebiha; Bex Camille; Lamesch Philippe; Sikorski Robert S; Vandenhaute Jean; Zoghbi Huda Y; Smolyar Alex; Bosak Stephanie; Sequerra Reynaldo; Doucette-Stamm Lynn; Cusick Michael E; Hill David E; Roth Frederick P; Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. England. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  3. ↑ Vallenius, T; Luukko K; Mäkelä T P (Apr 2000). "CLP-36 PDZ-LIM protein associates with nonmuscle alpha-actinin-1 and alpha-actinin-4". J. Biol. Chem. UNITED STATES. 275 (15): 11100–5. doi:10.1074/jbc.275.15.11100. ISSN 0021-9258. PMID 10753915.
  4. ↑ Kim, Jae Ho; Lee-Kwon Whaseon; Park Jong Bae; Ryu Sung Ho; Yun C H Chris; Donowitz Mark (Jun 2002). "Ca(2+)-dependent inhibition of Na+/H+ exchanger 3 (NHE3) requires an NHE3-E3KARP-alpha-actinin-4 complex for oligomerization and endocytosis". J. Biol. Chem. United States. 277 (26): 23714–24. doi:10.1074/jbc.M200835200. ISSN 0021-9258. PMID 11948184.
  5. ↑ Gonzalez, A M; Otey C; Edlund M; Jones J C (Dec 2001). "Interactions of a hemidesmosome component and actinin family members". J. Cell Sci. England. 114 (Pt 23): 4197–206. ISSN 0021-9533. PMID 11739652.
  6. ↑ 6.0 6.1 Walikonis, R S; Oguni A; Khorosheva E M; Jeng C J; Asuncion F J; Kennedy M B (Jan 2001). "Densin-180 forms a ternary complex with the (alpha)-subunit of Ca2+/calmodulin-dependent protein kinase II and (alpha)-actinin". J. Neurosci. United States. 21 (2): 423–33. PMID 11160423.
  7. ↑ Patrie, Kevin M; Drescher Andrew J; Welihinda Ajith; Mundel Peter; Margolis Ben (Aug 2002). "Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1". J. Biol. Chem. United States. 277 (33): 30183–90. doi:10.1074/jbc.M203072200. ISSN 0021-9258. PMID 12042308.
  8. ↑ El-Husseini, A E; Kwasnicka D; Yamada T; Hirohashi S; Vincent S R (Jan 2000). "BERP, a novel ring finger protein, binds to alpha-actinin-4". Biochem. Biophys. Res. Commun. UNITED STATES. 267 (3): 906–11. doi:10.1006/bbrc.1999.2045. ISSN 0006-291X. PMID 10673389.

Further reading

External links

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