Lung mass differential diagnosis: Difference between revisions
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{| class="wikitable" | {| class="wikitable" | ||
|- | |- | ||
!Type | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Category | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Category | ||
! colspan="2" |Disease | ! colspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Disease | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk/Epidemiology | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk/Epidemiology | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pleuripotent cells | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pleuripotent cells | ||
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! style="background:#4479BA; color: #FFFFFF;" align="center" + |Metastasis | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Metastasis | ||
|- | |- | ||
! rowspan="5" style="background:#4479BA; color: #FFFFFF;" align="center" + |Benign | |||
! rowspan="2" style="background:#DCDCDC;" align="center" + |[[Papilloma]]<ref name="pmid3969658">{{cite journal |vauthors=Maxwell RJ, Gibbons JR, O'Hara MD |title=Solitary squamous papilloma of the bronchus |journal=Thorax |volume=40 |issue=1 |pages=68–71 |date=January 1985 |pmid=3969658 |pmc=459982 |doi= |url=}}</ref> | |||
! colspan="2" style="background:#DCDCDC;" align="center" + |[[Squamous cell papilloma]] | |||
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* [[Human papillomavirus|HPV 6]] and [[Human papillomavirus|11]] | * [[Human papillomavirus|HPV 6]] and [[Human papillomavirus|HPV 11]] | ||
* Men | * Men | ||
* Median age of diagnosis is 54 years | * Median age of diagnosis is 54 years | ||
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* N/A | * N/A | ||
|- | |- | ||
! colspan="2" style="background:#DCDCDC;" align="center" + |Glandular papilloma | |||
| | | | ||
* Rare | * Rare | ||
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* N/A | * N/A | ||
|- | |- | ||
! rowspan="3" style="background:#DCDCDC;" align="center" + |Adenoma<ref name="pmid9817965">{{cite journal |vauthors=Shiota Y, Matsumoto H, Sasaki N, Taniyama K, Hashimoto S, Sueishi K |title=Solitary bronchioloalveolar adenoma of the lung |journal=Respiration |volume=65 |issue=6 |pages=483–5 |date=1998 |pmid=9817965 |doi=10.1159/000029319 |url=}}</ref> | |||
! colspan="2" style="background:#DCDCDC;" align="center" + |Alveolar adenoma | |||
| | | | ||
* Mean age of diagnosis is 53 years | * Mean age of diagnosis is 53 years | ||
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* N/A | * N/A | ||
|- | |- | ||
! colspan="2" style="background:#DCDCDC;" align="center" + |Papillary adenoma<ref name="pmid28409070">{{cite journal |vauthors=Kanchustambham V, Saladi S, Patolia S, Mahmoud Assaf S, Stoeckel D |title=A Rare Case of a Benign Primary Pleomorphic Adenoma of the Lung |journal=Cureus |volume=9 |issue=3 |pages=e1069 |date=March 2017 |pmid=28409070 |pmc=5375953 |doi=10.7759/cureus.1069 |url=}}</ref> | |||
| | | | ||
* Mean age of diagnosis is 32 years | * Mean age of diagnosis is 32 years | ||
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* N/A | * N/A | ||
|- | |- | ||
! colspan="2" style="background:#DCDCDC;" align="center" + |Mucinous cystadenoma | |||
| | | | ||
* No sex predilection | * No sex predilection | ||
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* N/A | * N/A | ||
|- | |- | ||
!Type | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Type | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Category | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Category | ||
! colspan="2" |Disease | ! colspan="2" style="background:#4479BA; color: #FFFFFF;" align="center" + |Disease | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk Factors/Epidemiology | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Risk Factors/Epidemiology | ||
! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pleuripotent cell | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Pleuripotent cell | ||
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! style="background:#4479BA; color: #FFFFFF;" align="center" + |Metastasis | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Metastasis | ||
|- | |- | ||
|Malignant | ! style="background:#4479BA; color: #FFFFFF;" align="center" + |Malignant | ||
! rowspan="3" style="background:#DCDCDC;" align="center" + |[[Squamous cell carcinoma of the lung|Squamous cell carcinoma]] (SCC)<ref name="pmid5528918">{{cite journal |vauthors=Roth E, Smidt D |title=[Studies on early ejaculate collection using electroejaculation in German improved land-swines and Goettinger miniature pigs] |language=German |journal=Berl. Munch. Tierarztl. Wochenschr. |volume=83 |issue=1 |pages=7–11 |date=January 1970 |pmid=5528918 |doi= |url=}}</ref> | |||
! colspan="2" style="background:#DCDCDC;" align="center" + |Papillary | |||
| rowspan="3" | | | rowspan="3" | | ||
* Cigarette smokers | * Cigarette smokers |
Revision as of 21:40, 24 January 2019
Lung Mass Microchapters |
Diagnosis |
---|
Treatment |
Lung mass differential diagnosis On the Web |
American Roentgen Ray Society Images of Lung mass differential diagnosis |
Risk calculators and risk factors for Lung mass differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2], Eiman Ghaffarpasand, M.D. [3]
Overview
Lung mass may be differentiated according to clinical features, laboratory findings, imaging features, histological features, and genetic studies, from other diseases that cause chronic cough, hemoptysis, and weight loss.
Differential Diagnosis
- The table below summarizes the findings that differentiate lung masses according to clinical features, laboratory findings, imaging features, histological features, and genetic studies.[1][2][3]
- Abrevations: HPV: human papillomavirus; CEA: Carcino embryogenic antigen; TTF1: Thyroid transcription factor-1; EMA: Epithelial membrane antigen; CK: Cyto keratin; CD: Cluster differentiation; NCAM: Neural Cell Differentiation Molecule; MMP's: Mettaloprotineases matrix; GFAP: Glial fibrocilliary acid protein
Type | Category | Disease | Risk/Epidemiology | Pleuripotent cells | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
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Benign | Papilloma[4] | Squamous cell papilloma |
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Glandular papilloma |
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Adenoma[5] | Alveolar adenoma |
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Papillary adenoma[6] |
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Mucinous cystadenoma |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Malignant | Squamous cell carcinoma (SCC)[7] | Papillary |
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Clear cell |
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Basaloid |
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Small cell carcinoma[8] |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Adenocarcinoma[9][10][11] | Acinar adenocarcinoma |
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Aerogenous spread is characteristic
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Papillary adenocarcinoma |
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Bronchio-alveolar carcinoma | Non-mucinous | ||||||||||
Mucinous |
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Mixed non-mucinous and mucinous or indeterminate |
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Solid adenocarcinoma with mucin production | Fetal adenocarcinoma |
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Mucinous (“colloid”) carcinoma |
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Mucinous cystadenocarcinoma |
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Signet ring adenocarcinoma |
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Clear cell adenocarcinoma |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Large cell carcinoma[12] | Basaloid large cell carcinoma of the lung |
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Clear cell carcinoma of the lung | |||||||||||
Lymphoepithelioma-like carcinoma of the lung |
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Large-cell lung carcinoma with rhabdoid phenotype |
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Mixed type |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Sarcomatoid carcinoma[13] | Carcinosarcoma |
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Spindle cell carcinoma |
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Giant cell carcinoma |
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Pleomorphic carcinoma |
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Pulmonary blastoma |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Carcinoid tumor[14] | Typical carcinoid
Atypical carcinoid |
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Salivary gland tumors[15] | Mucoepidermoid carcinoma |
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Adenoid cystic carcinoma |
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Epithelial-myoepithelial carcinoma |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Preinvasive lesions[16] | Squamous carcinoma in situ |
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Atypical adenomatous hyperplasia |
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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia |
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Type | Category | Disease | Risk Factors/Epidemiology | Pleuripotent cell | Topography | Gross | Histology | Immunohistochemistry | Imaging | Metastasis | |
Mesenchymal tumors[17] | Epithelioid haemangioendothelioma / Angiosarcoma |
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Pleuropulmonary blastoma |
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Chondroma |
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Congenital peribronchial myofibroblastic tumor |
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Diffuse pulmonary lymphangiomatosis |
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Inflammatory myofibroblastic tumor |
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Pulmonary artery sarcoma |
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Pulmonary vein sarcoma |
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References
- ↑ Erasmus JJ, Connolly JE, McAdams HP, Roggli VL (2000). "Solitary pulmonary nodules: Part I. Morphologic evaluation for differentiation of benign and malignant lesions". Radiographics. 20 (1): 43–58. doi:10.1148/radiographics.20.1.g00ja0343. PMID 10682770.
- ↑ Gümüştaş S, Inan N, Akansel G, Ciftçi E, Demirci A, Ozkara SK (June 2012). "Differentiation of malignant and benign lung lesions with diffusion-weighted MR imaging". Radiol Oncol. 46 (2): 106–13. doi:10.2478/v10019-012-0021-3. PMC 3472932. PMID 23077446.
- ↑ Kelley LC, Puette M, Langheinrich KA, King B (November 1994). "Bovine pulmonary blastomas: histomorphologic description and immunohistochemistry". Vet. Pathol. 31 (6): 658–62. doi:10.1177/030098589403100605. PMID 7863581.
- ↑ Maxwell RJ, Gibbons JR, O'Hara MD (January 1985). "Solitary squamous papilloma of the bronchus". Thorax. 40 (1): 68–71. PMC 459982. PMID 3969658.
- ↑ Shiota Y, Matsumoto H, Sasaki N, Taniyama K, Hashimoto S, Sueishi K (1998). "Solitary bronchioloalveolar adenoma of the lung". Respiration. 65 (6): 483–5. doi:10.1159/000029319. PMID 9817965.
- ↑ Kanchustambham V, Saladi S, Patolia S, Mahmoud Assaf S, Stoeckel D (March 2017). "A Rare Case of a Benign Primary Pleomorphic Adenoma of the Lung". Cureus. 9 (3): e1069. doi:10.7759/cureus.1069. PMC 5375953. PMID 28409070.
- ↑ Roth E, Smidt D (January 1970). "[Studies on early ejaculate collection using electroejaculation in German improved land-swines and Goettinger miniature pigs]". Berl. Munch. Tierarztl. Wochenschr. (in German). 83 (1): 7–11. PMID 5528918.
- ↑ Jackman DM, Johnson BE (2005). "Small-cell lung cancer". Lancet. 366 (9494): 1385–96. doi:10.1016/S0140-6736(05)67569-1. PMID 16226617.
- ↑ Mitchell, Richard Sheppard; Kumar, Vinay; Abbas, Abul K.; Fausto, Nelson. "Chapter 13, box on morphology of adenocarcinoma". Robbins Basic Pathology (8th ed.). Philadelphia: Saunders. ISBN 1-4160-2973-7.
- ↑ Soda M, Choi YL, Enomoto M, Takada S, Yamashita Y, Ishikawa S; et al. (2007). "Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer". Nature. 448 (7153): 561–6. doi:10.1038/nature05945. PMID 17625570.
- ↑ Adenocarcinoma of the lung. Librepathology 2015. http://librepathology.org/wiki/index.php/File:Adenocarcinoma_%283950819000%29.jpg
- ↑ Rossi G, Mengoli MC, Cavazza A, Nicoli D, Barbareschi M, Cantaloni C, Papotti M, Tironi A, Graziano P, Paci M, Stefani A, Migaldi M, Sartori G, Pelosi G (January 2014). "Large cell carcinoma of the lung: clinically oriented classification integrating immunohistochemistry and molecular biology". Virchows Arch. 464 (1): 61–8. doi:10.1007/s00428-013-1501-6. PMID 24221342.
- ↑ Huang SY, Shen SJ, Li XY (October 2013). "Pulmonary sarcomatoid carcinoma: a clinicopathologic study and prognostic analysis of 51 cases". World J Surg Oncol. 11: 252. doi:10.1186/1477-7819-11-252. PMC 3850921. PMID 24088577.
- ↑ Dahabreh J, Stathopoulos GP, Koutantos J, Rigatos S (March 2009). "Lung carcinoid tumor biology: treatment and survival". Oncol. Rep. 21 (3): 757–60. PMID 19212636.
- ↑ Elnayal A, Moran CA, Fox PS, Mawlawi O, Swisher SG, Marom EM (July 2013). "Primary salivary gland-type lung cancer: imaging and clinical predictors of outcome". AJR Am J Roentgenol. 201 (1): W57–63. doi:10.2214/AJR.12.9579. PMC 3767141. PMID 23789697.
- ↑ Greenberg AK, Yee H, Rom WN (2002). "Preneoplastic lesions of the lung". Respir. Res. 3: 20. PMC 107849. PMID 11980589.
- ↑ Koenigkam-Santos M, Sommer G, Puderbach M, Safi S, Schnabel PA, Kauczor HU, Heussel CP (April 2014). "Primary intrathoracic malignant mesenchymal tumours: computed tomography features of a rare group of chest neoplasms". Insights Imaging. 5 (2): 237–44. doi:10.1007/s13244-013-0306-0. PMC 3999366. PMID 24407922.