Acute promyelocytic leukemia classification: Difference between revisions
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===Cytogenetic-based classification=== | ===Cytogenetic-based classification=== | ||
The [[Karyotypes|karyotype]] of most cases of acute promyelocytic leukemia involves the t(15;17) [[translocation]] between the ''PML'' and [[RARA gene|''RARA'' genes]]. However, complex [[Karyotype|karyotypes]] may co-exist in some cases of acute promyelocytic leukemia.<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref> | *The [[Karyotypes|karyotype]] of most cases of acute promyelocytic leukemia involves the t(15;17) [[translocation]] between the ''PML'' and [[RARA gene|''RARA'' genes]]. However, complex [[Karyotype|karyotypes]] may co-exist in some cases of acute promyelocytic leukemia.<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref> | ||
*'''Complex karyotype''': Complex karyotype is defined as the presence of two or more [[Chromosomal abnormalities|chromosomal abnormities]]. Complex karyotype acute promyelocytic leukemia is associated with worse prognosis and lower rates of complete remission, similar to complex karyotype [[acute myeloid leukemia]]<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref>. Patients with complex karyotype are more likely to have a ''[[TP53]]'' [[mutation]] and are more likely to be resistant to [[chemotherapy]].<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref> | **'''Complex karyotype''': Complex karyotype is defined as the presence of two or more [[Chromosomal abnormalities|chromosomal abnormities]]. Complex karyotype acute promyelocytic leukemia is associated with worse prognosis and lower rates of complete remission, similar to complex karyotype [[acute myeloid leukemia]]<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref>. Patients with complex karyotype are more likely to have a ''[[TP53]]'' [[mutation]] and are more likely to be resistant to [[chemotherapy]].<ref name="pmid29541170">{{cite journal| author=Chen C, Huang X, Wang K, Chen K, Gao D, Qian S| title=Early mortality in acute promyelocytic leukemia: Potential predictors. | journal=Oncol Lett | year= 2018 | volume= 15 | issue= 4 | pages= 4061-4069 | pmid=29541170 | doi=10.3892/ol.2018.7854 | pmc=5835847 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29541170 }} </ref> | ||
*'''Trisomy 8''': [[Trisomy]] 8 is characterized by three copies of [[chromosome]] 8 in [[Cell (biology)|cells]]. This [[Chromosome|chromosomal abnormality]] is commonly found in patients with [[myelodysplastic syndrome]], which is a precursor condition for [[acute myeloid leukemia]]. Aside from t(15;17), [[trisomy]] 8 is the most frequent [[Chromosome abnormality|chromosomal abnormality]] in acute promyelocytic leukemia.<ref name="pmid29541170" /> | **'''Trisomy 8''': [[Trisomy]] 8 is characterized by three copies of [[chromosome]] 8 in [[Cell (biology)|cells]]. This [[Chromosome|chromosomal abnormality]] is commonly found in patients with [[myelodysplastic syndrome]], which is a precursor condition for [[acute myeloid leukemia]]. Aside from t(15;17), [[trisomy]] 8 is the most frequent [[Chromosome abnormality|chromosomal abnormality]] in acute promyelocytic leukemia.<ref name="pmid29541170" /> | ||
*'''Tetraploidy''': [[Tetraploidy]] is defined as the presence of four sets of [[chromosomes]] in a [[Cell (biology)|cell]]. [[Tetraploidy]] is generally rare in acute promyelocytic [[leukemia]] and accounts for approximately 0.75% of cases. The [[karyotype]] of most cases of acute promyelocytic leukemia involves the t(15;17) [[Translocations|translocation]] between the ''PML'' and [[RARA gene|''RARA'' genes]]. However, complex [[Karyotype|karyotypes]] may co-exist in some cases of acute promyelocytic leukemia. [[Polyploidy|Tetraploidy]] in acute promyelocytic leukemia is more commonly associated with [[CD2]] [[expression]] in the [[malignant]] [[cells]]. [[Tetraploidy|Tetraploid]] acute promyelocytic leukemia is mostly sensitive to all-''[[trans]]'' [[retinoic acid]].<ref name="pmid29541170" /> | **'''Tetraploidy''': [[Tetraploidy]] is defined as the presence of four sets of [[chromosomes]] in a [[Cell (biology)|cell]]. [[Tetraploidy]] is generally rare in acute promyelocytic [[leukemia]] and accounts for approximately 0.75% of cases. The [[karyotype]] of most cases of acute promyelocytic leukemia involves the t(15;17) [[Translocations|translocation]] between the ''PML'' and [[RARA gene|''RARA'' genes]]. However, complex [[Karyotype|karyotypes]] may co-exist in some cases of acute promyelocytic leukemia. [[Polyploidy|Tetraploidy]] in acute promyelocytic leukemia is more commonly associated with [[CD2]] [[expression]] in the [[malignant]] [[cells]]. [[Tetraploidy|Tetraploid]] acute promyelocytic leukemia is mostly sensitive to all-''[[trans]]'' [[retinoic acid]].<ref name="pmid29541170" /> | ||
*'''t(8;21)''': The t(8;21) [[Translocations|translocation]] sometimes co-exists with the t(15;17) [[Chromosomal translocation|translocation]]. The t(8;21) [[Translocations|translocation]] is more commonly found in [[acute myeloid leukemia]] and involves the juxtaposition of the ''ETO'' (''RUNX1T1'') [[gene]] on [[chromosome]] 8 with ''AML1'' (''[[RUNX1]]'') [[gene]] on [[chromosome]] 21. A total of six cases of coexisting t(8;21) and t(15;17) have thus far been described.<ref name="pmid8334990">{{cite journal |vauthors=Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M |title=The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript |journal=EMBO J. |volume=12 |issue=7 |pages=2715–21 |date=July 1993 |pmid=8334990 |pmc=413521 |doi= |url=}}</ref> | **'''t(8;21)''': The t(8;21) [[Translocations|translocation]] sometimes co-exists with the t(15;17) [[Chromosomal translocation|translocation]]. The t(8;21) [[Translocations|translocation]] is more commonly found in [[acute myeloid leukemia]] and involves the juxtaposition of the ''ETO'' (''RUNX1T1'') [[gene]] on [[chromosome]] 8 with ''AML1'' (''[[RUNX1]]'') [[gene]] on [[chromosome]] 21. A total of six cases of coexisting t(8;21) and t(15;17) have thus far been described.<ref name="pmid8334990">{{cite journal |vauthors=Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M |title=The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript |journal=EMBO J. |volume=12 |issue=7 |pages=2715–21 |date=July 1993 |pmid=8334990 |pmc=413521 |doi= |url=}}</ref> | ||
==References== | ==References== | ||
Revision as of 16:11, 28 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [3]
Classification
There are several broad classification schemes for acute promyelocytic leukemia. The most well-accepted classification scheme is risk-based classification, which categories patients into low-risk, intermediate-risk, or high-risk based on the white blood cell count and platelet count. Another classification scheme is based on the origin of the leukemia, which categorized patients as having de novo or therapy-related disease. A final classification scheme is cytogenetic-based, in which case specific chromosomal abnormalities are used to stratify patients.
Risk classification
- Low-risk disease: Low-risk disease is defined as the presence of less than 10000 white blood cells per microliter and greater than 40000 platelets per microliter in the peripheral blood. Treatment of low-risk disease involves non-chemotherapy-based regimens, such as the combination of all trance retinoic acid and arsenic trioxide.[1]
- Intermediate-risk disease: Intermediate-risk disease is defined as the presence of less than 10000 white blood cells per microliter and less than 40000 platelets per microliter in peripheral blood.[2]
- High-risk disease: High-risk disease is defined as the presence of greater than 10000 white blood cells per microliter in peripheral blood, regardless of the platelet count. Platelet count is typically less than 40000 cells per microliter, though platelet count is not a formal criterion in the classification of acute promyelocytic leukemia.[1]
Origin-based classification
- De novo disease: De novo acute promyelocytic leukemia is the most common subtype. This refers to development of the disease in the absence of prior cytotoxic therapy or prior precursor conditions. De novo acute promyelocytic leukemia is due to a sporadic events in cells, without prior DNA damaging insults. This is in contrast to therapy-related disease.
- Therapy-related disease: Therapy-related disease refers to the development of acute promyelocytic leukemia in patients who were previously treated with DNA-damaging or genotoxic agents for other conditions, such as other cancers. The most common DNA-damaging agents that cause therapy-associated acute promyelocytic leukemia are topoisomerase inhibitors and alkylating agents. Therapy-related acute promyelocytic leukemia is typically seen in patients with a history of breast cancer who received cyclophosphamide or patients with a history of a germ cell tumor who have received etoposide. The prognosis of therapy-related disease is worse than that of de novo disease, with a 5-year survival of less than 10 years. The 4-year overall survival for therapy-related disease is 24.5%, compared to 39.5% for de novo disease.[3]
- Topoisomerase II inhibitors: This class of chemotherapeutics causes early-onset leukemia, with a typical latency of 2-3 years from the receipt of the topoisomerase inhibitor. Cytogenetics from the leukemia diagnosis typically shows the MLL rearrangement (chromosome 11q23). There is usually no preceding myelodysplastic phase; the onset of leukemia is relatively sudden.[4]
- Alkylating agents: This class of chemotherapeutics causes late-onset leukemia, with a typical latency of greater than 7 years from the receipt of the alkylating agent. Cytogenetics from the leukemia diagnosis typically shows monosomy 5 or monosomy 7. Mutational analyses can show a TP53 mutation. There is usually a preceding myelodysplastic phase.[4]
- Other chemotherapeutic agents: Although other chemotherapy medications are not classically associated with therapy-related acute promyelocytic leukemia, there have been cases of such associations. In a patient with gastric cancer treated with oxaliplatin and capecitabine, acute promyelocytic leukemia developed after a latency period of 4 years. The leukemic cells had chromosomal abnormalities, suggesting that the secondary neoplasm was chemotherapy-induced rather than de novo.[3]
Cytogenetic-based classification
- The karyotype of most cases of acute promyelocytic leukemia involves the t(15;17) translocation between the PML and RARA genes. However, complex karyotypes may co-exist in some cases of acute promyelocytic leukemia.[5]
- Complex karyotype: Complex karyotype is defined as the presence of two or more chromosomal abnormities. Complex karyotype acute promyelocytic leukemia is associated with worse prognosis and lower rates of complete remission, similar to complex karyotype acute myeloid leukemia[5]. Patients with complex karyotype are more likely to have a TP53 mutation and are more likely to be resistant to chemotherapy.[5]
- Trisomy 8: Trisomy 8 is characterized by three copies of chromosome 8 in cells. This chromosomal abnormality is commonly found in patients with myelodysplastic syndrome, which is a precursor condition for acute myeloid leukemia. Aside from t(15;17), trisomy 8 is the most frequent chromosomal abnormality in acute promyelocytic leukemia.[5]
- Tetraploidy: Tetraploidy is defined as the presence of four sets of chromosomes in a cell. Tetraploidy is generally rare in acute promyelocytic leukemia and accounts for approximately 0.75% of cases. The karyotype of most cases of acute promyelocytic leukemia involves the t(15;17) translocation between the PML and RARA genes. However, complex karyotypes may co-exist in some cases of acute promyelocytic leukemia. Tetraploidy in acute promyelocytic leukemia is more commonly associated with CD2 expression in the malignant cells. Tetraploid acute promyelocytic leukemia is mostly sensitive to all-trans retinoic acid.[5]
- t(8;21): The t(8;21) translocation sometimes co-exists with the t(15;17) translocation. The t(8;21) translocation is more commonly found in acute myeloid leukemia and involves the juxtaposition of the ETO (RUNX1T1) gene on chromosome 8 with AML1 (RUNX1) gene on chromosome 21. A total of six cases of coexisting t(8;21) and t(15;17) have thus far been described.[6]
References
- ↑ 1.0 1.1 Coombs CC, Tavakkoli M, Tallman MS (2015). "Acute promyelocytic leukemia: where did we start, where are we now, and the future". Blood Cancer J. 5: e304. doi:10.1038/bcj.2015.25. PMC 4450325. PMID 25885425.
- ↑ McCulloch D, Brown C, Iland H (2017). "Retinoic acid and arsenic trioxide in the treatment of acute promyelocytic leukemia: current perspectives". Onco Targets Ther. 10: 1585–1601. doi:10.2147/OTT.S100513. PMC 5359123. PMID 28352191.
- ↑ 3.0 3.1 Zhang YC, Zhou YQ, Yan B, Shi J, Xiu LJ, Sun YW; et al. (2015). "Secondary acute promyelocytic leukemia following chemotherapy for gastric cancer: a case report". World J Gastroenterol. 21 (14): 4402–7. doi:10.3748/wjg.v21.i14.4402. PMC 4394105. PMID 25892894.
- ↑ 4.0 4.1 Zahid MF, Parnes A, Savani BN, Litzow MR, Hashmi SK (2016). "Therapy-related myeloid neoplasms - what have we learned so far?". World J Stem Cells. 8 (8): 231–42. doi:10.4252/wjsc.v8.i8.231. PMC 4999650. PMID 27621757.
- ↑ 5.0 5.1 5.2 5.3 5.4 Chen C, Huang X, Wang K, Chen K, Gao D, Qian S (2018). "Early mortality in acute promyelocytic leukemia: Potential predictors". Oncol Lett. 15 (4): 4061–4069. doi:10.3892/ol.2018.7854. PMC 5835847. PMID 29541170.
- ↑ Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (July 1993). "The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript". EMBO J. 12 (7): 2715–21. PMC 413521. PMID 8334990.