Spina bifida natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
==Natural History, Complications, and | == Natural History, Complications and Prognosis== | ||
*Prognosis of patients with spina bifida is generally poor. | |||
*Early clinical features include:<ref name="pmid10350196">{{cite journal |vauthors=Soonawala N, Overweg-Plandsoen WC, Brouwer OF |title=Early clinical signs and symptoms in occult spinal dysraphism: a retrospective case study of 47 patients |journal=Clin Neurol Neurosurg |volume=101 |issue=1 |pages=11–4 |date=March 1999 |pmid=10350196 |doi= |url=}}</ref><ref name="pmid4898641">{{cite journal |vauthors=Bannur BB, Purandare GM |title=Microbial production of L-lysine |journal=Hindustan Antibiot Bull |volume=11 |issue=3 |pages=191–205 |date=February 1969 |pmid=4898641 |doi= |url=}}</ref><ref name="pmid2647936">{{cite journal |vauthors=Horton D, Barnes P, Pendleton BD, Pollay M |title=Spina bifida occulta: early clinical and radiographic diagnosis |journal=J Okla State Med Assoc |volume=82 |issue=1 |pages=15–9 |date=January 1989 |pmid=2647936 |doi= |url=}}</ref> | |||
**Weakness or [[paralysis]] in the legs. | |||
**[[Urinary incontinence]] | |||
**[[Bowel]] incontinence | |||
**[[Sensation]] problems in the [[lower extremity]] | |||
**[[Motor]] problems in the [[lower extrimity]] | |||
**[[Hydrocephalus]] | |||
*If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries.<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | |||
*[[Renal failure]] is the commonest cause of death in patients with spina bifida.<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | |||
*Common complications of [disease name] include:<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | |||
**[[Cardiac]] disease | |||
**[[Respiratory disease]] | |||
**[[Suicidality]] | |||
**[[Cancer]] | |||
*The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis. | *The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis. | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Natural History, Complications and Prognosis
- Prognosis of patients with spina bifida is generally poor.
- Early clinical features include:[1][2][3]
- Weakness or paralysis in the legs.
- Urinary incontinence
- Bowel incontinence
- Sensation problems in the lower extremity
- Motor problems in the lower extrimity
- Hydrocephalus
- If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries.[4]
- Renal failure is the commonest cause of death in patients with spina bifida.[4]
- Common complications of [disease name] include:[4]
- Cardiac disease
- Respiratory disease
- Suicidality
- Cancer
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
References
- ↑ Soonawala N, Overweg-Plandsoen WC, Brouwer OF (March 1999). "Early clinical signs and symptoms in occult spinal dysraphism: a retrospective case study of 47 patients". Clin Neurol Neurosurg. 101 (1): 11–4. PMID 10350196.
- ↑ Bannur BB, Purandare GM (February 1969). "Microbial production of L-lysine". Hindustan Antibiot Bull. 11 (3): 191–205. PMID 4898641.
- ↑ Horton D, Barnes P, Pendleton BD, Pollay M (January 1989). "Spina bifida occulta: early clinical and radiographic diagnosis". J Okla State Med Assoc. 82 (1): 15–9. PMID 2647936.
- ↑ 4.0 4.1 4.2 Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C (August 1987). "Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development". Am. J. Clin. Nutr. 46 (2): 360–8. doi:10.1093/ajcn/46.2.360. PMID 2441590.