Syndrome of inappropriate antidiuretic hormone classification: Difference between revisions
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! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Classification}} | ! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Classification}} | ||
! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Features}} | ! style="background: #4479BA; width: 300px;" | {{fontcolor|#FFF|Features}} | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type A | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type A | ||
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*Associated with [[lung cancer]] and [[Nasopharyngeal Carcinoma|nasopharyngeal tumors]] | *Associated with [[lung cancer]] and [[Nasopharyngeal Carcinoma|nasopharyngeal tumors]] | ||
* Patients are more susceptible to development of severe [[hyponatremia]] | * Patients are more susceptible to development of severe [[hyponatremia]] | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type B | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type B | ||
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*Accounts for (20–40%) of the cases | *Accounts for (20–40%) of the cases | ||
*Secretion of [[AVP]] occurs at lower than normal [[Plasma osmolality|plasma osmolalities]] | *Secretion of [[AVP]] occurs at lower than normal [[Plasma osmolality|plasma osmolalities]] | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type C | | style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type C | ||
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*Associated with gain-of-function [[mutations]] in the vasopressin-2 ([[V2 receptor|V2]]) [[V2 receptor|receptor]] leading to a clinical picture of [[SIADH]], with undetectable [[AVP]] levels | *Associated with gain-of-function [[mutations]] in the vasopressin-2 ([[V2 receptor|V2]]) [[V2 receptor|receptor]] leading to a clinical picture of [[SIADH]], with undetectable [[AVP]] levels | ||
*The condition is inherited in an [[X-linked]] manner, although [[heterozygous]] [[females]] may have inappropriate anti-[[diuresis]] of varying degrees. | *The condition is inherited in an [[X-linked]] manner, although [[heterozygous]] [[females]] may have inappropriate anti-[[diuresis]] of varying degrees. | ||
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| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; text-align:center;" |Type E | |||
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* "characterized by a decline in plasma copeptin levels with increasing saline-stimulated serum osmolality...baseline hypovolemia could not be identified...Theoretically, an alternative explanation of type E could be a reversed osmotic response from stimulation to inhibition"<ref name="pmid24722436">{{cite journal| author=Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M | display-authors=etal| title=A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis. | journal=J Am Soc Nephrol | year= 2014 | volume= 25 | issue= 10 | pages= 2376-83 | pmid=24722436 | doi=10.1681/ASN.2013080895 | pmc=4178436 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24722436 }} </ref> | |||
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==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
Revision as of 15:20, 2 July 2022
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
SIADH may be classified into several sub-types based on the pattern of arginine vasopressin (AVP) secretion in response to a range of plasma osmolalities into type A, type B, type C, and type D.
Classification
SIADH may be classified into several sub-types based on the pattern of arginine vasopressin (AVP) secretion across a range of plasma osmolalities:[1][2][3]
| Classification | Features |
|---|---|
| Type A |
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| Type B |
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| Type C |
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| Type D |
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| Type E |
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References
- ↑ Hannon MJ, Thompson CJ (2010). "The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences". Eur. J. Endocrinol. 162 Suppl 1: S5–12. doi:10.1530/EJE-09-1063. PMID 20164214.
- ↑ Yamauchi T, Makinodan M, Nagashima T, Kiuchi K, Noriyama Y, Kishimoto T (2009). "Type d syndrome of inappropriate antidiuretic hormone secretion in a schizophrenia patient with polydipsia". J Brain Dis. 1: 25–7. PMC 3676320. PMID 23818806.
- ↑ Gross P (2012). "Clinical management of SIADH". Ther Adv Endocrinol Metab. 3 (2): 61–73. doi:10.1177/2042018812437561. PMC 3474650. PMID 23148195.
- ↑ Fenske WK, Christ-Crain M, Hörning A, Simet J, Szinnai G, Fassnacht M; et al. (2014). "A copeptin-based classification of the osmoregulatory defects in the syndrome of inappropriate antidiuresis". J Am Soc Nephrol. 25 (10): 2376–83. doi:10.1681/ASN.2013080895. PMC 4178436. PMID 24722436.