Follicular lymphoma: Difference between revisions
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==Pathophysiology== | ==Pathophysiology== | ||
==Causes== | ==Causes== | ||
Revision as of 16:29, 21 September 2012
| Follicular lymphoma | |
| ICD-10 | C82 |
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| ICD-9 | 202.0 |
| MeSH | D008224 |
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Follicular lymphoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Follicular lymphoma On the Web |
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American Roentgen Ray Society Images of Follicular lymphoma |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Pathophysiology
Causes
A translocation between chromosome 14 and 18 results in the overexpression of the bcl2 gene. This overexpression causes a blockage of apoptosis, or programmed cell death. This translocation has been associated with the development of Follicular lymphoma.
Treatment
There is no consensus regarding the best treatment algorithm, but watch-and-wait policies, alkylators, anthracycline-containing regimens (eg. CHOP), rituximab, autologous and allogenic hematopoietic stem cell transplantation have all been applied. The disease is regarded as incurable (although allogenic stem cell transplantation may be curative, the mortality from the procedure is too high to be a first line option). The exception is localized disease, which can be cured by local irradiation. The typical pattern is one of good responses from treatment, followed by relapses some years later. Median survival is around 10 years, but the range is wide, from less than one year, to more than 20 years. Some patients may never need treatment.