Peutz-Jeghers syndrome pathophysiology
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Peutz-Jeghers syndrome is transmitted in autosomal dominant pattern.
Pathophysiology
Genetics
Peutz-Jeghers syndrome is caused by a mutation in STK11 (LKB1) tumor suppressor gene on chromosome 19.[1] It is inherited in an autosomal dominant pattern, which means that anyone who has Peutz-Jeghers syndrome (PJS) has a 50% chance of passing it onto his/her offspring.
References
- ↑ JReferences Jenne DE, et al. 'Peutz-Jeghers Syndrome Is Caused By Mutations In A Novel Serine Threonine Kinase. - Pubmed - NCBI'. Ncbi.nlm.nih.gov. N.p., 2015. Web. 9 Sept. 2015..