Syndrome of inappropriate antidiuretic hormone screening
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Diagnosis of SIADH:[1]
- Decreased effective osmolality of the extracellular fluid (Posm <275 mOsmol/kg H2O).
- Inappropriate urinary concentration (Uosm >100 mOsmol/kg H2O with normal renal function) at some level of plasma hypo-osmolality.
- Clinical euvolemic hyponatremia (hyponatremia plus normal extra cellular fluid volume)
- Spot sodium levels ≥ 20-30 mmol/L.
- Absence of other potential causes of euvolemic hyponatremia: severe hypothyroidism, hypocortisolism.
- Normal renal function and absence of diuretic use, particularly thiazide diuretics.
References
- ↑ Verbalis, JG.; Goldsmith, SR.; Greenberg, A.; Korzelius, C.; Schrier, RW.; Sterns, RH.; Thompson, CJ. (2013). "Diagnosis, evaluation, and treatment of hyponatremia: expert panel recommendations". Am J Med. 126 (10 Suppl 1): S1–42. doi:10.1016/j.amjmed.2013.07.006. PMID 24074529. Unknown parameter
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