Transitional cell carcinoma classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

Based on the growth pattern, transitional cell tumors may be classified into two subtypes:

Type	Description
Papillary urothelial carcinoma	Have slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity
Non-papillary urothelial carcinomas	Lay flat in the lining of the renal pelvis and ureter They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity

WHO Classification

The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumors:

Transitional cell tumors

Infiltrating urothelial carcinoma with squamous differentiation with glandular differentiation with trophoblastic differentiation Nested Microcystic Micropapillary Lymphoepithelioma-like Lymphoma-like Plasmacytoid Sarcomatoid Giant cell Undifferentiated

Non-invasive urothelial carcinoma Urothelial carcinoma in situ High grade papillary urothelial carcinoma Low grade papillary urothelial carcinoma Non-invasive papillary urothelial neoplasm of low malignant potential Urothelial papilloma Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are two grades of transitional cell carcinoma based on the degree of cellular differentiation:

Grade	Description
Low grade	Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy
High grade	Tumors with the most severe degrees of cellular anaplasia