Syndrome of inappropriate antidiuretic hormone causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

SIADH is caused by excess of renal water reabsorption through inappropriate antidiuretic hormone secretion, there are various causes attributed to SIADH ranging from malignancies, drugs, central nervous system causes , infectious and other miscellaneous causes. Some of the most common causes are : malignancies like small cell lung cancer, drugs like selective serotonin reuptake inhibitors, and carbamazapine.[1]

Syndrome of inappropriate antidiuretic hormone causes

Common causes

Head injury

Causes by Organ System

Cardiovascular No underlying causes
Chemical / poisoning Mesothelioma
Cardiovascular No underlying causes
Chemical / poisoning Mesothelioma
Dermatologic No underlying causes
Drug Side Effect Carbamazepine, Chlorpropamide, Cyclophosphamide, Desmopressin, Mono Amine Oxidase Inhibitors, Nicotine, Oxytocin, Pergolide, Phenothiazines, SSRIs, Tricyclic antidepressants, Tolbutamide, Vasopressin, Vinblastine, Vincristine, Bromocriptine,Clofibrate,Prostaglandins,Melphalan,Interferon-alpha,Tacrolimus, Diclofenac, Ibuprofen, Fentanyl, Amiodarone, Hydrochlorthiazide, Clonidine,Levodopa,Rituximab, Methylene dioxy methamphetamine, Leveteiracetam, Quinolones.
Ear Nose Throat No underlying causes
Endocrine Carcinoid,Hypopituitarism,Hypothyroidism
Environmental Mesothelioma
Gastroenterologic Carcinoid, Duodenal carcinoma, Pancreatic cancer
Genetic Agenesis corpus collosum, Amyotropic lateral sclerosis, Hydrocephalus, Midline defects, Multiple sclerosis
Hematologic Thymoma, Acute intermittent porphyria
Iatrogenic No underlying causes
Infectious Disease AIDS, Bacterial pneumonia, Brain abscess, Encephalitis, Lung abscess, Lung cavitation, Meningitis, Tuberculosis
Musculoskeletal / Ortho Amyotropic lateral sclerosis, Ewing's sarcoma, Polyradiculitis
Neurologic Agenesis corpus collosum, Amyotropic lateral sclerosis, Brain abscess, Carcinoid, Cavernous sinus thrombosis, Delirium tremens, Encephalitis, Hydrocephalus, Meningitis, Multiple sclerosis, Peripheral neuropathy, Polyradiculitis, Stroke,Subarachnoid hemorrhage, Subdural hemorrhage,Guillian barre syndrome, Traumatic brain injury
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic Ovarian cancer
Oncologic Bronchial adenoma, Carcinoid, Duodenal carcinoma, Ewing's sarcoma, Lung carcinoma, Mesothelioma, Ovarian cancer, Pancreatic cancer, Thymoma
Opthalmologic No underlying causes
Overdose / Toxicity Delirium tremens
Psychiatric Phenothiazines, Psychosis
Pulmonary Asthma, Bacterial pneumonia, Bronchial adenoma, Carcinoid, Lung abscess, Lung carcinoma, Lung cavitation, Mesothelioma, Pneumothorax, Tuberculosis
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Asthma
Sexual No underlying causes
Trauma Pneumothorax
Urologic No underlying causes
Miscellaneous Positive pressure ventilation, transsphenoidal surgery[3]

Causes in Alphabetical Order

References

[4]


Template:WikiDoc Sources

  1. ↑ Oh JY, Shin JI (2014). "Syndrome of inappropriate antidiuretic hormone secretion and cerebral/renal salt wasting syndrome: similarities and differences". Front Pediatr. 2: 146. doi:10.3389/fped.2014.00146. PMC 4302789. PMID 25657991.
  2. ↑ Hannon MJ, Thompson CJ (2010). "The syndrome of inappropriate antidiuretic hormone: prevalence, causes and consequences". Eur. J. Endocrinol. 162 Suppl 1: S5–12. doi:10.1530/EJE-09-1063. PMID 20164214.
  3. ↑ Hussain NS, Piper M, Ludlam WG, Ludlam WH, Fuller CJ, Mayberg MR (2013). "Delayed postoperative hyponatremia after transsphenoidal surgery: prevalence and associated factors". J. Neurosurg. 119 (6): 1453–60. doi:10.3171/2013.8.JNS13411. PMID 24053496.
  4. ↑ Pillai BP, Unnikrishnan AG, Pavithran PV (2011). "Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder". Indian J Endocrinol Metab. 15 Suppl 3: S208–15. doi:10.4103/2230-8210.84870. PMC 3183532. PMID 22029026.
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