Syndrome of inappropriate antidiuretic hormone
| Syndrome of inappropriate antidiuretic hormone | |
| ICD-10 | E22.2 |
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| ICD-9 | 253.6 |
| DiseasesDB | 12050 |
| MedlinePlus | 003702 |
| MeSH | D007177 |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and Keywords: SIADH; syndrome of inappropriate antidiuretic hormone secretion; inappropriate ADH syndrome; Schwartz-Bartter syndrome.
Overview
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) was initially described by Leaf and Mamby. SIADH consists of hyponatremia, inappropriately elevated urine osmolality, excessive urine sodium and decreased serum osmolality in a euvolemic patient without edema. These findings should occur in the absence of diuretic treatment with normal cardiac, renal, adrenal, hepatic and thyroid function. Hyponatremia occurs in about 30% of hospitalized patients and SIADH is the most frequent cause of hyponatremia. Differentiating hyponatremia due to SIADH from other causes of hyponatremia becomes essential to evaluate the treatment plan.
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Syndrome of inappropriate antidiuretic hormone from other Diseases
Syndrome of inappropriate antidiuretic hormone secretion (SIADH) was initially described by Leaf and Mamby. [1] SIADH consists of hyponatremia, inappropriately elevated urine osmolality, excessive urine sodium and decreased serum osmolality in a euvolemic patient without edema. These findings should occur in the absence of diuretic treatment with normal cardiac, renal, adrenal, hepatic and thyroid function. Hyponatremia occurs in about 30% of hospitalized patients [2] and SIADH is the most frequent cause of hyponatremia
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X Ray | CT | MRI | Echocardiography or Ultrasound | Other Imaging Findings | Other Diagnostic Studies
Treatment
Medical Therapy | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies
Case Studies
it:Sindrome da inappropriata secrezione di ADH nl:Syndroom van inadequate secretie van antidiuretisch hormoon