Syndrome of inappropriate antidiuretic hormone laboratory findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

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Overview

Lab findings helpful in diagnosing SIADH, include serum electrolytes,especially sodium,BUN,creatinine, glucose levels, and osmolality. Patients with syndrome of inappropriate antidiuretic hormone may be characterised with hyponatremia (sodium <135 mEq/L) and low serum osmolality (<280 mOsm/kg). Patients with syndrome of inappropriate antidiuretic hormone show elevated urinary sodium level (>20 mmol/L) and urine osmolality (generally >100 mOsm/L). They also have low BUN, normal creatinine,low uric acid and low albumin.

Laboratory Findings

• Serum tests include electrolytes, BUN, creatinine, glucose levels, and osmolality. Patients with syndrome of inappropriate antidiuretic hormone may be characterised with hyponatremia (sodium <135 mEq/L) and low serum osmolality (<280 mOsm/kg).
• Urine tests: Patients with syndrome of inappropriate antidiuretic hormone show elevated urinary sodium level (>20 mmol/L) and urine osmolality (generally >100 mOsm/L).
• Low BUN
• Normal Creatinine
• Low uric acid
• Low albumin

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