Diphyllobothriasis medical therapy

Diphyllobothriasis Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Diphyllobothriasis from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
History and Symptoms
Physical Examination
Laboratory Findings
X Ray
CT Scan
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Primary Prevention
Secondary Prevention
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Diphyllobothriasis medical therapy On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
slides
Images
American Roentgen Ray Society Images of Diphyllobothriasis medical therapy All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Diphyllobothriasis medical therapy
CDC on Diphyllobothriasis medical therapy
Diphyllobothriasis medical therapy in the news
Blogs on Diphyllobothriasis medical therapy
Directions to Hospitals Treating Diphyllobothriasis
Risk calculators and risk factors for Diphyllobothriasis medical therapy

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Kalsang Dolma, M.B.B.S.[2], Furqan M M. M.B.B.S[3]

Overview

Medical therapy is the primary modality of treatment for diphyllobothriasis. Drugs used for diphyllobothriasis include either praziquantel or niclosamide.

Medical Therapy

The medications used in the treatment of diphyllobothriasis are:

• Praziquantel
• Niclosamide

Antimicrobial Regimen

The dose for empiric treatment of diphyllobothriasis is as follows:

• Diphyllobothriasis
  • 1.1 Adult
    • Preferred regimen (1): Praziquantel 5-10 mg/kg orally in a single-dose therapy; for adults and children.
    • Alternative regimen (1): Niclosamide 2 gm single dose orally for adults; children, 50 mg/kg (max 2 gm) orally once.

Mechanism of action

1. Praziquantel
   • Oral praziquantel is available for human use in the United States. Praziquantel increases the permeability of the cell membrane towards calcium ions. This induces contraction of the parasites, resulting in paralysis in the contracted state.
2. Niclosamide
   • Niclosamide inhibits the oxidative phosphorylation and anaerobic metabolism in the parasites.