Syndrome of inappropriate antidiuretic hormone causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

SIADH is caused by excess of renal water reabsorption through inappropriate antidiuretic hormone secretion, there are various causes attributed to SIADH ranging from malignancies, drugs, central nervous system causes, infectious.Some of the most common causes are : malignancies like small cell lung cancer, drugs like selective serotonin reuptake inhibitors, and carbamazapine

Syndrome of inappropriate antidiuretic hormone causes

Common causes

Head injury

Causes by Organ System

Chemical / poisoning Mesothelioma
Cardiovascular No underlying causes
Chemical / poisoning Mesothelioma
Dermatologic No underlying causes
Drugs Cyclophosphamide, Desmopressin, Mono amine oxidase inhibitors, Nicotine, Oxytocin, Pergolide, Phenothiazines, SSRIs, Tricyclic antidepressants,Monoamine oxidase inhibitors, Vasopressin, Vinblastine, Vincristine, Bromocriptine, Clofibrate, Prostaglandins, Melphalan, Interferon-alpha, Tacrolimus, Diclofenac, Ibuprofen, Fentanyl, Amiodarone, Hydrochlorthiazide, Clonidine, Levodopa, Rituximab, methylenedioxy methamphetamine, Leveteiracetam, Quinolones
Ear Nose Throat No underlying causes
Endocrine Carcinoid, Hypopituitarism, Hypothyroidism
Environmental Mesothelioma
Gastroenterologic Carcinoid, Duodenal carcinoma, Pancreatic cancer
Genetic Agenesis corpus collosum, Amyotropic lateral sclerosis, Hydrocephalus, Midline defects, Multiple sclerosis
Hematologic Thymoma, Acute intermittent porphyria
Iatrogenic No underlying causes
Infectious Disease AIDS, Bacterial pneumonia, Brain abscess, Encephalitis, Lung abscess, Lung cavitation, Meningitis, Tuberculosis
Musculoskeletal / Ortho Amyotropic lateral sclerosis, Ewing's sarcoma, Polyradiculitis
Neurologic Agenesis corpus collosum, Amyotropic lateral sclerosis, Brain abscess, Carcinoid, Cavernous sinus thrombosis, Delirium tremens, Encephalitis, Hydrocephalus, Meningitis, Multiple sclerosis, Peripheral neuropathy, Polyradiculitis, Stroke, Subarachnoid hemorrhage, Subdural hemorrhage, Guillian barre syndrome, Traumatic brain injury
Nutritional / Metabolic No underlying causes
Obstetric/Gynecologic Ovarian cancer
Oncologic Bronchial adenoma, Carcinoid, Duodenal carcinoma, Ewing's sarcoma, Lung carcinoma, Mesothelioma, Ovarian cancer, Pancreatic cancer, Thymoma
Opthalmologic No underlying causes
Overdose / Toxicity Delirium tremens
Psychiatric Phenothiazines, Psychosis
Pulmonary Asthma, Bacterial pneumonia, Bronchial adenoma, Carcinoid, Lung abscess, Lung carcinoma, Lung cavitation, Mesothelioma, Pneumothorax, Tuberculosis
Renal / Electrolyte No underlying causes
Rheum / Immune / Allergy Asthma
Sexual No underlying causes
Trauma Pneumothorax
Urologic No underlying causes
Miscellaneous Positive pressure ventilation, Transsphenoidal surgery , Poly-arteritis nodosa

Causes in Alphabetical Order

References


Template:WikiDoc Sources

  1. ↑ Pillai BP, Unnikrishnan AG, Pavithran PV (2011). "Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder". Indian J Endocrinol Metab. 15 Suppl 3: S208–15. doi:10.4103/2230-8210.84870. PMC 3183532. PMID 22029026.
  2. ↑ Schrier RW (2006). "Body water homeostasis: clinical disorders of urinary dilution and concentration". J. Am. Soc. Nephrol. 17 (7): 1820–32. doi:10.1681/ASN.2006030240. PMID 16738014.
  3. ↑ Derubertis FR, Michelis MF, Bloom ME, Mintz DH, Field JB, Davis BB (1971). "Impaired water excretion in myxedema". Am. J. Med. 51 (1): 41–53. PMID 5570319.
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