SLC4A4
| Solute carrier family 4, sodium bicarbonate cotransporter, member 4 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLC4A4 ; DKFZp781H1314; HNBC1; KNBC; NBC1; NBC2; SLC4A5; hhNMC; pNBC | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 55776 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC4A4 203908 at tn.png | |||||||||||
| File:PBB GE SLC4A4 210738 s at tn.png | |||||||||||
| File:PBB GE SLC4A4 210739 x at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 4, sodium bicarbonate cotransporter, member 4, also known as SLC4A4, is a human gene.[1]
Sodium bicarbonate cotransporters (NBCs) mediate the coupled movement of sodium and bicarbonate ions across the plasma membrane of many cells. This is an electrogenic process with an apparent stoichiometry of 3 bicarbonate ions per sodium ion. Sodium bicarbonate cotransport is involved in bicarbonate secretion/absorption and intracellular pH regulation. Romero and Boron (1999) reviewed NBCs. Soleimani and Burnham (2000) reviewed NBCs and their regulation in physiologic and pathophysiologic states.[supplied by OMIM][1]
See also
References
Further reading
- Romero MF, Boron WF (1999). "Electrogenic Na+/HCO3- cotransporters: cloning and physiology". Annu. Rev. Physiol. 61: 699–723. doi:10.1146/annurev.physiol.61.1.699. PMID 10099707.
- Soleimani M, Burnham CE (2000). "Physiologic and molecular aspects of the Na+:HCO3- cotransporter in health and disease processes". Kidney Int. 57 (2): 371–84. doi:10.1046/j.1523-1755.2000.00857.x. PMID 10652014.
- Burnham CE, Amlal H, Wang Z; et al. (1997). "Cloning and functional expression of a human kidney Na+:HCO3- cotransporter". J. Biol. Chem. 272 (31): 19111–4. PMID 9235899.
- Abuladze N, Lee I, Newman D; et al. (1998). "Molecular cloning, chromosomal localization, tissue distribution, and functional expression of the human pancreatic sodium bicarbonate cotransporter". J. Biol. Chem. 273 (28): 17689–95. PMID 9651366.
- Choi I, Romero MF, Khandoudi N; et al. (1999). "Cloning and characterization of a human electrogenic Na+-HCO-3 cotransporter isoform (hhNBC)". Am. J. Physiol. 276 (3 Pt 1): C576–84. PMID 10069984.
- Igarashi T, Inatomi J, Sekine T; et al. (1999). "Mutations in SLC4A4 cause permanent isolated proximal renal tubular acidosis with ocular abnormalities". Nat. Genet. 23 (3): 264–6. doi:10.1038/15440. PMID 10545938.
- Pushkin A, Yip KP, Clark I; et al. (2000). "NBC3 expression in rabbit collecting duct: colocalization with vacuolar H+-ATPase". Am. J. Physiol. 277 (6 Pt 2): F974–81. PMID 10600945.
- Park K, Hurley PT, Roussa E; et al. (2002). "Expression of a sodium bicarbonate cotransporter in human parotid salivary glands". Arch. Oral Biol. 47 (1): 1–9. PMID 11743927.
- Gross E, Hawkins K, Pushkin A; et al. (2002). "Phosphorylation of Ser(982) in the sodium bicarbonate cotransporter kNBC1 shifts the HCO(3)(-) : Na(+) stoichiometry from 3 : 1 to 2 : 1 in murine proximal tubule cells". J. Physiol. (Lond.). 537 (Pt 3): 659–65. PMID 11744745.
- Gross E, Pushkin A, Abuladze N; et al. (2003). "Regulation of the sodium bicarbonate cotransporter kNBC1 function: role of Asp(986), Asp(988) and kNBC1-carbonic anhydrase II binding". J. Physiol. (Lond.). 544 (Pt 3): 679–85. PMID 12411514.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Tatishchev S, Abuladze N, Pushkin A; et al. (2003). "Identification of membrane topography of the electrogenic sodium bicarbonate cotransporter pNBC1 by in vitro transcription/translation". Biochemistry. 42 (3): 755–65. doi:10.1021/bi026826q. PMID 12534288.
- Gross E, Fedotoff O, Pushkin A; et al. (2004). "Phosphorylation-induced modulation of pNBC1 function: distinct roles for the amino- and carboxy-termini". J. Physiol. (Lond.). 549 (Pt 3): 673–82. doi:10.1113/jphysiol.2003.042226. PMID 12730338.
- Sun XC, Bonanno JA (2003). "Identification and cloning of the Na/HCO(3-) cotransporter (NBC) in human corneal endothelium". Exp. Eye Res. 77 (3): 287–95. PMID 12907161.
- Yamada H, Yamazaki S, Moriyama N; et al. (2003). "Localization of NBC-1 variants in human kidney and renal cell carcinoma". Biochem. Biophys. Res. Commun. 310 (4): 1213–8. PMID 14559244.
- Alvarez BV, Loiselle FB, Supuran CT; et al. (2003). "Direct extracellular interaction between carbonic anhydrase IV and the human NBC1 sodium/bicarbonate co-transporter". Biochemistry. 42 (42): 12321–9. doi:10.1021/bi0353124. PMID 14567693.
- Becker HM, Deitmer JW (2004). "Voltage dependence of H+ buffering mediated by sodium bicarbonate cotransport expressed in Xenopus oocytes". J. Biol. Chem. 279 (27): 28057–62. doi:10.1074/jbc.M402401200. PMID 15123668.
- Pushkin A, Abuladze N, Gross E; et al. (2005). "Molecular mechanism of kNBC1-carbonic anhydrase II interaction in proximal tubule cells". J. Physiol. (Lond.). 559 (Pt 1): 55–65. doi:10.1113/jphysiol.2004.065110. PMID 15218065.
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