SLC22A18
| Solute carrier family 22 (organic cation transporter), member 18 | |||||||||||
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| Identifiers | |||||||||||
| Symbols | SLC22A18 ; BWR1A; BWSCR1A; DKFZp667A184; HET; IMPT1; ITM; ORCTL2; SLC22A1L; TSSC5; p45-BWR1A | ||||||||||
| External IDs | Template:OMIM5 Template:MGI HomoloGene: 1918 | ||||||||||
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| RNA expression pattern | |||||||||||
| File:PBB GE SLC22A18 204981 at tn.png | |||||||||||
| More reference expression data | |||||||||||
| Orthologs | |||||||||||
| Template:GNF Ortholog box | |||||||||||
| Species | Human | Mouse | |||||||||
| Entrez | n/a | n/a | |||||||||
| Ensembl | n/a | n/a | |||||||||
| UniProt | n/a | n/a | |||||||||
| RefSeq (mRNA) | n/a | n/a | |||||||||
| RefSeq (protein) | n/a | n/a | |||||||||
| Location (UCSC) | n/a | n/a | |||||||||
| PubMed search | n/a | n/a | |||||||||
Solute carrier family 22 (organic cation transporter), member 18, also known as SLC22A18, is a human gene.[1]
This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region as well as the transport of chloroquine- and quinidine-related compounds in the kidney. Two alternative transcripts encoding the same isoform have been described.[1]
See also
References
Further reading
- Akiyama S (2002). "[Mechanisms of drug resistance and reversal of the resistance]". Hum. Cell. 14 (4): 257–60. PMID 11925925.
- Dao D, Frank D, Qian N; et al. (1998). "IMPT1, an imprinted gene similar to polyspecific transporter and multi-drug resistance genes". Hum. Mol. Genet. 7 (4): 597–608. PMID 9499412.
- Schwienbacher C, Sabbioni S, Campi M; et al. (1998). "Transcriptional map of 170-kb region at chromosome 11p15.5: identification and mutational analysis of the BWR1A gene reveals the presence of mutations in tumor samples". Proc. Natl. Acad. Sci. U.S.A. 95 (7): 3873–8. PMID 9520460.
- Cooper PR, Smilinich NJ, Day CD; et al. (1998). "Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain". Genomics. 49 (1): 38–51. doi:10.1006/geno.1998.5221. PMID 9570947.
- Reece M, Prawitt D, Landers J; et al. (1998). "Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules". FEBS Lett. 433 (3): 245–50. PMID 9744804.
- Lee MP, Reeves C, Schmitt A; et al. (1998). "Somatic mutation of TSSC5, a novel imprinted gene from human chromosome 11p15.5". Cancer Res. 58 (18): 4155–9. PMID 9751628.
- Morisaki H, Hatada I, Morisaki T, Mukai T (1999). "A novel gene, ITM, located between p57KIP2 and IPL, is imprinted in mice". DNA Res. 5 (4): 235–40. PMID 9802569.
- Onyango P, Miller W, Lehoczky J; et al. (2001). "Sequence and comparative analysis of the mouse 1-megabase region orthologous to the human 11p15 imprinted domain". Genome Res. 10 (11): 1697–710. PMID 11076855.
- Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
- Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Yamada HY, Gorbsky GJ (2006). "Tumor suppressor candidate TSSC5 is regulated by UbcH6 and a novel ubiquitin ligase RING105". Oncogene. 25 (9): 1330–9. doi:10.1038/sj.onc.1209167. PMID 16314844.
- Gallagher E, Mc Goldrick A, Chung WY; et al. (2006). "Gain of imprinting of SLC22A18 sense and antisense transcripts in human breast cancer". Genomics. 88 (1): 12–7. doi:10.1016/j.ygeno.2006.02.004. PMID 16624517.
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