Angiopoietin receptor

tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
Symbol	TIE1
Alt. symbols	TIE, JTK14
Entrez	7075
HUGO	11809
OMIM	600222
RefSeq	NM_005424
UniProt	P35590
Other data
EC number	2.7.1.112
Locus	Chr. 1 p34-p33

TEK tyrosine kinase, endothelial
Identifiers
Symbol	TEK
Alt. symbols	TIE2, TIE-2, VMCM1, CD202b
Entrez	7010
HUGO	11724
OMIM	600221
RefSeq	NM_000459
UniProt	Q02763
Other data
Locus	Chr. 9 p21

The angiopoietin receptors are receptors that bind angiopoietin.

TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins, (Ang1, Ang2, Ang3, Ang4). The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

Angiopoietins

The angiopoietins are protein growth factors that promote angiogenesis, the formation of blood vessels. There are now four identified angiopoietins: Ang1, Ang2, Ang3, Ang4. Ang1 and Ang4 function as agonistic or activating ligands for Tie2, whereas Ang2 and Ang3 behave as competitive antagonists. They function by binding their physiologic receptors, Tie-1 and Tie-2. These are receptor tyrosine kinases, so named because they mediate cell signals by inducing the phosphorylation of key tyrosines, thus initiating cell signalling.

It is somewhat controversial which of the Tie receptors mediate functional signals downstream of Ang stimulation. But it is clear that at least Tie-2 is capable of physiologic activation as a result of binding the angiopoietins.

See also

• Angiopoietin#Tie_pathway

External links

• TIE+Receptor+Tyrosine+Kinases at the US National Library of Medicine Medical Subject Headings (MeSH)