Follicular lymphoma laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Laboratory tests in the diagnosis of follicular lymphoma include histological confirmation, immunophenotyping, immunohistochemistry, molecular genetic analysis and cytogenetics.
Laboratory Findings
Laboratory findings consistent with the diagnosis of follicular lymphoma includes[1]
- Histological confirmation by centroblasts and centrocytes
- Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+
- Immunohistochemistry for Ki-67,Aggressive clinical behavior is in association with low-grade follicular lymphoma with a high proliferation index. ( determined by Ki-67 immunostaining)
- Molecular genetic analysis for BCL2 rearrangement
- Cytogenetics or FISH for t(14;18)