Transitional cell carcinoma classification

Transitional cell carcinoma Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Classification

In the United States, bladder cancers usually start from the cells lining the bladder (called transitional cells).

These tumors are classified based on the way they grow:

• Papillary tumors have a wart-like appearance and are attached to a stalk.
• Nonpapillary (sessile) tumors are much less common. However, they are more invasive and have a worse outcome.

The World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) published a consensus opinion classification system for urothelial (transitional cell) tumours

Transitional cell carcinoma

Infiltrating urothelial carcinoma with squamous differentiation with glandular differentiation with trophoblastic differentiation Nested Microcystic Micropapillary Lymphoepithelioma-like Lymphoma-like Plasmacytoid Sarcomatoid Giant cell Undifferentiated

Non-invasive urothelial carcinoma Urothelial carcinoma in situ High grade papillary urothelial carcinoma Low grade papillary urothelial carcinoma Non-invasive papillary urothelial neoplasm of low malignant potential

Grading

According to the WHO grading criteria, there are three grades of transitional cell carcinoma based on the degree of cellular differentiation:

Grade	Description
Grade 1	Tumors with the least degree of cellular anaplasia compatible with a diagnosis of malignancy
Grade 2	Histologic features between grades 1 and 3
Grade 3	Tumors with the most severe degrees of cellular anaplasia