Chronic renal failure causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2] Luke Rusowicz-Orazem, B.S.
Overview
Common causes of chronic renal failure include diabetic nephropathy, hypertension, and glomerulonephritis. The commonest cause of stage 5 CKD in the U.S. is diabetes and is characterized by proteinuria and bilaterally enlarged kidneys. Hypertension is the second most common cause of Stage 5 CKD in the US, and often co-exists in diabetic patients.
Causes of Chronic Kidney Disease
According to the National Kidney Foundation the 2 most important causes of CKD are diabetes and hypertension accounting for more than one third of all cases often indicating early detection strategies. Beyond diabetes and hypertension other causes like glomerulonephritis, inherited disorders, chronic infections, and urinary tract obstruction account for most of the remaining cases.[1] Following the 2013 US Renal Data System report, a detailed calculation of the most common etiologies of ESRD in the United States adjusted for age, race and gender is shown below:[2]
Common Causes
- Alport's syndrome
- Amyloidosis
- Balkan endemic nephropathy
- Benign prostatic hyperplasia
- Chronic Glomerulonephritis
- Chronic Pyelonephritis
- Cystinosis
- Diabetic nephropathy
- Glomerulosclerosis
- Goodpasture’s syndrome
- Hemolytic uremic syndrome
- Hereditary nephritides
- Hyperoxaluria
- Hypertensive nephrosclerosis
- IgA nephropathy
- Interstitial Nephritis
- Light chain disease
- Lupus nephritis
- Malignant hypertension
- Medullary cystic kidney disease
- Medullary sponge kidney
- Membranoproliferative Glomerulonephritis
- Membranous nephritis
- Metastatic prostate cancer
- Multiple Myeloma
- Nephrolithiasis
- Nephrosclerosis
- Nephrotic Syndrome
- Nephritic Syndrome
- Normocytic normochromic anemia
- Obstructive uropathy
- Oxalosis
- Papillorenal syndrome
- Polycystic kidney disease
- Proteinuria
- Prostate cancer
- Pyelonephritis
- Reflux nephropathy
- Renal artery stenosis
- Renal cell carcinoma
- Renal vein thrombosis
- Renal tubular acidosis
- Rheumatoid arthritis
- Scleroderma
- Sepsis
- Sickle cell disease
- Systemic sclerosis
- Thrombotic thrombocytopenic purpura
- Renal tubular acidosis
- Vasculitis
- Vesicoureteral reflux
- Wegener's granulomatosis
Causes by Organ System
Causes in Alphabetical Order
- Ace inhibitors
- Acetominophen
- Action myoclonus
- Acute intermittent porphyria
- Acyclovir
- Adenine phosphoribosyltransferase deficiency
- Allopurinol
- Alport's syndrome
- Alström syndrome
- Aminoglycosides
- Amphotericin b
- Amyloidosis
- Angiotensin-converting enzyme inhibitors
- Anticoagulants
- Aspirin
- Balkan endemic nephropathy
- Barakat syndrome
- Bardet-biedl syndrome
- Benign prostatic hyperplasia
- Bevacizumab
- Bismuth
- Carbon tetrachloride
- Carboplatin
- Carmustine
- Cefoxitin
- Chloroquine
- Chronic glomerulonephritis
- Chronic pyelonephritis
- Cimetidine
- Cisplatin
- Cocaine
- Congenital nephrotic syndrome
- Cyclosporine
- Cystinosis
- Dense deposit disease
- Dent disease
- Denys-drash syndrome
- Diabetes mellitus type 1
- Diabetes mellitus type 2
- Diabetic nephropathy
- Diflunisal
- Dioctophyma renale
- Erythromycin
- Essential hypertension
- Fabry's disease
- Familial juvenile hyperuricemic nephropathy
- Febuxostat
- Ferumoxytol
- Fibronectin glomerulopathy
- Finnish congenital nephrotic syndrome
- Flucytosine
- Focal segmental glomerulosclerosis
- Foscarnet
- Frasier syndrome
- Furosemide
- Gadopentetate
- Galloway-mowat syndrome
- Gentamicin
- Glomerular hypertrophy
- Glomerulocystic kidney disease
- Glomerulonephritis
- Glomerulosclerosis
- Glycogenosis type 1b
- Goodpasture’s syndrome
- Gout
- Granulomatosis with polyangiitis
- Hemolytic uremic syndrome
- Hereditary nephritides
- Hereditary onycho-osteodysplasia
- Hydronephrosis
- Hydroxychloroquine
- Hyperkalemia
- Hyperlipidemia
- Hyperoxaluria
- Hyperoxaluria, primary type 1
- Hyperoxaluria, primary type 2
- Hyperoxaluria, primary type 3
- Hypertension
- Hypertensive nephrosclerosis
- Hyperuricemic nephropathy, familial juvenile type 1
- Hyperuricemic nephropathy, familial juvenile type 2
- Hypotension
- Hypovolemia
- Idiopathic membranous nephropathy
- Idiopathic multicentric osteolysis
- Ifosfamide
- Iga nephropathy
- Infliximab
- Interferons
- Interstitial nephritis
- Intraglomerular hypertension
- Isoniazid
- Jeune thoracic dystrophy syndrome
- Laxatives
- Lead
- Lecithin cholesterol acyltransferase deficiency
- Lesch-nyhan syndrome
- Light chain disease
- Lithium
- Loken senior syndrome
- Lomustine
- Lowe syndrome
- Lupus
- Lupus nephritis
- Mainzer-saldino disease
- Malignant hypertension
- Medullary cystic kidney disease
- Medullary cystic renal disease
- Medullary sponge kidney
- Membranoproliferative glomerulonephritis
- Membranous nephritis
- Mesalamine
- Metabolic acidosis
- Metastatic prostate cancer
- Methicillin
- Mitomycin c
- Multiple myeloma
- Nephritic syndrome
- Nephrolithiasis
- Nephrosclerosis
- Nephrotic syndrome
- Nitrosourea
- Normocytic normochromic anemia
- Nsaids
- Obstructive nephropathy
- Obstructive uropathy
- Oxalosis
- Pamidronate
- Papillorenal syndrome
- Penicillin
- Pentamidine
- Phenytoin
- Polycystic kidney disease
- Propylthiouracil
- Prostate cancer
- Protease inhibitors
- Proteinuria
- Pyelonephritis
- Quinine
- Radiocontrast agents
- Recurrent hereditary polyserositis
- Reflux nephropathy
- Renal artery stenosis
- Renal cell carcinoma
- Renal tubular acidosis
- Renal vein thrombosis
- Rheumatoid arthritis
- Rifampicin
- Saxagliptin
- Schistosoma haematobium
- Scleroderma
- Sensenbrenner syndrome
- Sepsis
- Sickle cell disease
- Sulfa-containing antibiotics
- Sulfonamides
- Sulindac
- Systemic hypertension
- Systemic sclerosis
- Tacrolimus
- Thiazides
- Thrombotic thrombocytopenic purpura
- Tizanidine
- Townes-brocks syndrome
- Trimethoprim
- Tubulointerstitial disease
- Urinary tract obstruction
- Vancomycin
- Vasculitis
- Vesicoureteral reflux
- Wegener's granulomatosis
- Xanthogranulomatous pyelonephritis
- X-linked hypophosphataemia
- X-linked recessive nephrolithiasis type 1
References
- ↑ Levey AS, Coresh J, Balk E, Kausz AT, Levin A, Steffes MW; et al. (2003). "National Kidney Foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification". Ann Intern Med. 139 (2): 137–47. PMID 12859163 Check
|pmid=
value (help). - ↑ U.S. Renal Data System, 2013 Annual Data Report: Atlas of Chronic Kidney Disease and End-Stage Renal Disease in the United States, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD, 2013.