Syndrome of inappropriate antidiuretic hormone risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]

Overview

The most common causes of SIADH are malignancy, pulmonary disorders, CNS disorders and medications.

Risk Factors

• Central nervous system disease: Brain tumors, trauma, infection such as meningitis and encephalitis, Guillain-Barré syndrome, delirium tremens, multiple sclerosis
• Pulmonary disease: Small cell lung cancer, pneumonia, chronic obstructive pulmonary disease, lung abscess, tuberculosis, cystisc fibrosis, positive-pressure ventilation
• Cancer: Lung cancer, pancreas cancer, thymoma, ovarian cancer, lymphoma, laryngeal cancer, Nasopharyngeal carcinoma, bladder cancer, prostate cancer, breast cancer, melanoma.
• Drugs: Nonsteroidal anti-inflammatory drugs, nicotine, diuretics, chlorpropamide, carbamazepine, tricyclic antidepressants, selective serotonin reuptake inhibitors, vincristine, thioridazine, cyclophosphamide, clofibrate, bromocriptine, haloperidol, thiothixene, exogenous oxytocin.
• Surgery: Damage to the hypothalamus or pituitary gland during or after surgery
• Idiopathic

References

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