Alzheimer's disease risk factors
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
The most potent risk factors for the development of Alzheimer's dementia (AD) are age and
Risk Factors
The following are the risk factors leading to the development of Alzheimer's dementia (AD):[1][2][3]
- Age
- Gender
- Early-life negative events and physical attributes
- Literacy and education
- APOE ε4 is a risk factor for AD among women but not men in Venezuela
- Late onset APOE gene mutation associated Alzheimers's dementia (AD) is affected by the following factors:
- Ethnicity
- Age
- Sex
- Medical history
- Geographical location (Central African Republic, East Africa, Southern Africa, Malaysia, Australia, and Papua New Guinea)
- Stroke
- Vascular disease
- Diet (fruits, vegetables, and fibre decrease risk; Tofu, cycad fruit, salivary phytooestrogens e.g. genistein and daidizein are associated with increased risk)
References
- ↑ Kalaria RN, Maestre GE, Arizaga R, Friedland RP, Galasko D, Hall K, Luchsinger JA, Ogunniyi A, Perry EK, Potocnik F, Prince M, Stewart R, Wimo A, Zhang ZX, Antuono P (2008). "Alzheimer's disease and vascular dementia in developing countries: prevalence, management, and risk factors". Lancet Neurol. 7 (9): 812–26. doi:10.1016/S1474-4422(08)70169-8. PMC 2860610. PMID 18667359.
- ↑ Dong MJ, Peng B, Lin XT, Zhao J, Zhou YR, Wang RH (2007). "The prevalence of dementia in the People's Republic of China: a systematic analysis of 1980-2004 studies". Age Ageing. 36 (6): 619–24. doi:10.1093/ageing/afm128. PMID 17965036.
- ↑ Nitrini R, Caramelli P, Herrera E, Bahia VS, Caixeta LF, Radanovic M, Anghinah R, Charchat-Fichman H, Porto CS, Carthery MT, Hartmann AP, Huang N, Smid J, Lima EP, Takada LT, Takahashi DY (2004). "Incidence of dementia in a community-dwelling Brazilian population". Alzheimer Dis Assoc Disord. 18 (4): 241–6. PMID 15592138.