Peutz-Jeghers syndrome screening
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]
Overview
Screening for cancerous lesions by small intestine radiography, esophagogastroduodenoscopy (EGD), colonoscopy, pancreatic ultrasound, pelvic ultrasound, mammography, and Papanicolaou test (Pap test) is recommended among patients with Peutz-Jeghers syndrome.
Screening
Patients who are at risk of developing Peutz-Jeghers syndrome are screened for the locations of the hamartomas by:[1]
At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:[1]
- Small bowel video capsule endoscopy (every 3 years)
- Stomach Esophagogastroduodenoscopy (every 3 years)
- Colonoscopy (every 3 years)
- Pancreas (every 1-2 years)
- Abdominal CT
- Pelvic ultrasound (annually)
- Testicular exam (annually)
- If abnormalities palpable perform an ultrasound
- Mammography starting at age 25 (annually)
- Endometrial pelvic exam and ultrasound (annually)
- Cervical Papanicolaou test (Pap test) (annually).
- Physical examination that includes evaluation of the breasts, abdomen, pelvis, and testes should be performed by a physician (annually)
- Complete blood count (CBC) to check for anemia should be done (annually)
References
- ↑ 1.0 1.1 Syngal, Sapna; Brand, Randall E; Church, James M; Giardiello, Francis M; Hampel, Heather L; Burt, Randall W (2015). "ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes". The American Journal of Gastroenterology. 110 (2): 223–262. doi:10.1038/ajg.2014.435. ISSN 0002-9270.