SIN3B

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Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a
Wikidata
View/Edit Human

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.

Interactions

SIN3B has been shown to interact with HDAC1, Zinc finger and BTB domain-containing protein 16, SUDS3 and IKZF1.

See also

• Transcription coregulator

Further reading

• Ayer DE, Lawrence QA, Eisenman RN (Mar 1995). "Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3". Cell. 80 (5): 767–76. doi:10.1016/0092-8674(95)90355-0. PMID 7889570.
• David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
• Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
• Naruse Y, Aoki T, Kojima T, Mori N (Nov 1999). "Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes". Proceedings of the National Academy of Sciences of the United States of America. 96 (24): 13691–6. doi:10.1073/pnas.96.24.13691. PMC 24126. PMID 10570134.
• Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW (Dec 2000). "The Mad1-Sin3B interaction involves a novel helical fold". Nature Structural Biology. 7 (12): 1100–4. doi:10.1038/81944. PMID 11101889.
• Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW (Apr 2001). "Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1". Journal of Biomolecular NMR. 19 (4): 377–8. doi:10.1023/A:1011262214741. PMID 11370785.
• Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
• Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD (Apr 2002). "E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex". Genes & Development. 16 (8): 933–47. doi:10.1101/gad.969202. PMC 152357. PMID 11959842.
• Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.
• Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA (Feb 2003). "An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B". The Biochemical Journal. 369 (Pt 3): 651–7. doi:10.1042/BJ20020854. PMC 1223118. PMID 12398767.
• Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". The Journal of Biological Chemistry. 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.
• Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W (Apr 2003). "Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1". Genes & Development. 17 (7): 896–911. doi:10.1101/gad.252103. PMC 196026. PMID 12670868.
• Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N (Nov 2004). "Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential". Oncogene. 23 (55): 8887–99. doi:10.1038/sj.onc.1208107. PMID 15467743.
• Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S (Oct 2005). "Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex". Molecular and Cellular Biology. 25 (19): 8415–29. doi:10.1128/MCB.25.19.8415-8429.2005. PMC 1265755. PMID 16166625.
• Xu Y, Sengupta PK, Seto E, Smith BD (Apr 2006). "Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression". The Journal of Biological Chemistry. 281 (14): 9260–70. doi:10.1074/jbc.M511724200. PMC 1434794. PMID 16464847.

External links

• SIN3B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.