Atopic dermatitis natural history, complications and prognosis
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
Natural History, Complications, and Prognosis
Natural History
- The symptoms of atopic dermatitis usually starts during the first years of life, and presents with symptoms such as intense pruritus and chronic and relapsing age dependent eczematous lesions.[1]
- Majority of the infants and children with atopic dermatitis, usually grow out of the disease during childhood.[2]
- In severe cases, atopic dermatitis continue or relapses in adulthood.[3]
- Natural history of atopic dermatitis can be categorized into various subtypes according to the clinical features.
- The most common subtype was characterized by the early onset of atopic dermatitis (<2 years) and persistent until adulthood.[4]
- In the sequence of atopy march diseases, atopic dermatits is the first to commence during infancy, followed by allergic rhinits, food allergy and asthma later in life.[5]
- Atopic dermatitis is a life long disease with periods of waxing and waning eczematous skin lesions.[6]
Complications
- Common complications of atopic dermatitis include:
- Superinfection
- Staphyloccus aureus
- herpes simplex virus
- Superinfection
Prognosis
- Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [--]%.
- Depending on the extent of the [tumor/disease progression] at the time of diagnosis, the prognosis may vary. However, the prognosis is generally regarded as poor/good/excellent.
- The presence of [characteristic of disease] is associated with a particularly [good/poor] prognosis among patients with [disease/malignancy].
- [Subtype of disease/malignancy] is associated with the most favorable prognosis.
- The prognosis varies with the [characteristic] of tumor; [subtype of disease/malignancy] have the most favorable prognosis.
Complications
- Infections of the skin caused by bacteria, fungi, or viruses
- Permanent scars
- Side effects from long-term use of medicines to control eczema
Prognosis
Atopic dermatitis is a long-term condition. You can control it with treatment, by avoiding irritants, and by keeping the skin well-moisturized. In children, the condition often starts to go away around age 5 - 6, but flare-ups will often occur. In adults, the problem is generally a long-term or returning condition. Atopic dermatitis may be harder to control if it:
- Begins at an early age
- Involves a large amount of the body
- Occurs along with allergic rhinitis and asthma
- Occurs in someone with a family history of eczema
References
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Burr ML, Dunstan FD, Hand S, Ingram JR, Jones KP (June 2013). "The natural history of eczema from birth to adult life: a cohort study". Br. J. Dermatol. 168 (6): 1339–42. doi:10.1111/bjd.12216. PMID 23301666.
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Garmhausen D, Hagemann T, Bieber T, Dimitriou I, Fimmers R, Diepgen T, Novak N (April 2013). "Characterization of different courses of atopic dermatitis in adolescent and adult patients". Allergy. 68 (4): 498–506. doi:10.1111/all.12112. PMID 23452057.
- ↑ Spergel JM (August 2010). "From atopic dermatitis to asthma: the atopic march". Ann. Allergy Asthma Immunol. 105 (2): 99–106, quiz 107–9, 117. doi:10.1016/j.anai.2009.10.002. PMID 20674819.
- ↑ Margolis JS, Abuabara K, Bilker W, Hoffstad O, Margolis DJ (June 2014). "Persistence of mild to moderate atopic dermatitis". JAMA Dermatol. 150 (6): 593–600. doi:10.1001/jamadermatol.2013.10271. PMC 4352328. PMID 24696036.